High Res

Fukun Guo, PhD

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-803-1118

Email fukun.guo@cchmc.org

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Research Interests

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Rho GTPases and T and B lymphocyte development and function

Education and Training

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BS: Jilin University, Changchun, Jilin, China, 1994.

MS: Academy of Military Medical Sciences, Beijing, China, 1997.

PhD: Southern Medical University, Guangzhou, Guangdong, China, 2000.

Postdoctoral Research Associate: University of Tennessee, Memphis, TN, 2000-2002; Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2002-2004.

Research Associate: Southern Medical University, Guangzhou, Guangdong, China, 2000; Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2004.

Research Instructor: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH. 2005-2009.

Publications

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View PubMed Publications

Yang JQ, Kalim KW, Li Y, Zhang S, Hinge A, Filippi MD, Zheng Y, Guo F3. RhoA orchestrates glycolysis for Th2 cell differentiation and allergic airway inflammation. J Allergy Clin Immunol. 2016;137(1):231.e4.

Zhang S, Konstantinidis DG, Yang JQ, Mizukawa B, Kalim K, Lang RA, Kalfa TA, Zheng Y, Guo F. Gene targeting RhoA reveals its essential role in coordinating mitochondrial function and thymocyte development. Journal of Immunology. 2014;193(12):5973.

Guo F, Li J, Zhang S, Du W, Amarachintha S, Sipple J, Phelan J, Grimes HL, Zheng Y, Pang Q. mTOR kinase inhibitor sensitizes T-cell lymphoblastic leukemia for chemotherapy-induced DNA damage via suppressing FANCD2 expression. Leukemia. 2014;28(1):203.

Guo F, Li J, Du W, Zhang S, O'Connor M, Thomas G, Kozma S, Zingarelli B, Pang Q, Zheng Y. mTOR regulates DNA damage response through NF-κB-mediated FANCD2 pathway in hematopoietic cells. Leukemia. 2013;27(10):2040.

Guo F, Zhang S, Grogg M, Cancelas JA, Varney ME, Starczynowski DT, Du W, Yang JQ, Liu W, Thomas G, Kozma S, Pang Q, Zheng Y. Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis. Haematologica. 2013;98(9):1353.

Zhang S, Zhou X, Lang RA, Guo F. RhoA of the Rho family small GTPases is essential for B lymphocyte development. PLoS One. 2012.7(3):e33773.

Guo F, Zhang S, Tripathi P, Mattner J, Phelan J, Sproles A, Mo J, Wills-Karp M, Grimes HL, Hildeman D, Zheng Y. Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation. PLoS One. 2011;6(3):e18002.

Guo F, Hildeman D, Tripathi P, Velu CS, Grimes HL, Zheng Y. Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 2010;107(43):18505.

Guo F, Velu CS, Grimes HL, Zheng Y. Rho GTPase Cdc42 is essential for B lymphocyte development and activation. Blood. 2009;114(14):2909.

Guo F, Cancelas JA, Hildeman D, Williams DA, Zheng Y. Rac GTPase isoforms, Rac1 and Rac2, play a redundant and crucial role in T-cell development. Blood. 2008;112(5):1767.

Grants

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Novel Signaling Function of Cdc42 GTPase in vivo. Principal Investigator. National Institutes of Health. 2014-2018. R01 GM108661.

Novel therapeutics of targeting mTOR pathway in T-cell leukemia. Principal Investigator. National Institutes of Health. 2015-2017. R21 CA198358-01.

Pilot Award. Principal Investigator. National Institutes of Health. 2016. P30DK090971.