A photo of Fukun Guo.

Member, Division of Experimental Hematology & Cancer Biology

Associate Professor, UC Department of Pediatrics


Biography & Affiliation

Research Interests

Rho GTPases and T and B lymphocyte development and function

Academic Affiliation

Associate Professor, UC Department of Pediatrics


Experimental Hematology and Cancer Biology, Cancer and Blood Diseases


BS: Jilin University, Changchun, Jilin, China, 1994.

MS: Academy of Military Medical Sciences, Beijing, China, 1997.

PhD: Southern Medical University, Guangzhou, Guangdong, China, 2000.

Postdoctoral Research Associate: University of Tennessee, Memphis, TN, 2000-2002; Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2002-2004.

Research Associate: Southern Medical University, Guangzhou, Guangdong, China, 2000; Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2004.

Research Instructor: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH. 2005-2009.


Dopamine D1 and D2 Receptors Differentially Regulate Rac1 and Cdc42 Signaling in the Nucleus Accumbens to Modulate Behavioral and Structural Plasticity After Repeated Methamphetamine Treatment. Tu, G; Ying, L; Ye, L; Zhao, J; Liu, N; Li, J; Liu, Y; Zhu, M; Wu, Y; Xiao, B; et al. Biological Psychiatry. 2019; 86:820-835.

Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation. Yang, JQ; Kalim, KW; Li, Y; Zheng, Y; Guo, F. Journal of Leukocyte Biology. 2019; 106:1139-1151.

Inhibition of Rho-Kinase Downregulates Th17 Cells and Ameliorates Hepatic Fibrosis by Schistosoma japonicum Infection. Zhou, W; Yang, Y; Mei, C; Dong, P; Mu, S; Wu, H; Zhou, Y; Zheng, Y; Guo, F; Yang, J. Cells. 2019; 8:1262-1262.

Rational Targeting of Cdc42 Overcomes Drug Resistance of Multiple Myeloma. Nguyen, P; Chakrabarti, J; Li, Y; Kalim, KW; Zhang, M; Zhang, L; Zheng, Y; Guo, F. Frontiers in Oncology. 2019; 9.

Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization. Liu, W; Du, W; Shang, X; Wang, L; Evelyn, C; Florian, MC; Ryan, MA; Rayes, A; Zhao, X; Setchell, K; et al. Leukemia. 2019; 33:749-761.

Rational targeting Cdc42 restrains Th2 cell differentiation and prevents allergic airway inflammation. Yang, J; Kalim, KW; Li, Y; Duan, X; Nguyen, P; Hershey, GK K; Kroner, J; Ruff, B; Zhang, L; Salomonis, N; et al. Clinical and Experimental Allergy. 2019; 49:92-107.

mDia1 and Cdc42 Regulate Activin B-Induced Migration of Bone Marrow-Derived Mesenchymal Stromal Cells. Wang, X; Tang, P; Guo, F; Zhang, M; Yan, Y; Huang, M; Chen, Y; Zhang, L; Zhang, L. Stem Cells. 2019; 37:150-162.

Cdc42 Deficiency Leads To Epidermal Barrier Dysfunction by Regulating Intercellular Junctions and Keratinization of Epidermal Cells during Mouse Skin Development. Zhang, M; Wang, X; Guo, F; Jia, Q; Liu, N; Chen, Y; Yan, Y; Huang, M; Tang, H; Deng, Y; et al. Theranostics. 2019; 9:5065-5084.

Different roles of Rac1 in the acquisition and extinction of methamphetamine-associated contextual memory in the nucleus accumbens. Zhao, J; Ying, L; Liu, Y; Liu, N; Tu, G; Zhu, M; Wu, Y; Xiao, B; Ye, L; Li, J; et al. Theranostics. 2019; 9:7051-7071.

Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury. Lv, J; Zeng, J; Guo, F; Li, Y; Xu, M; Cheng, Y; Zhang, L; Cai, S; Chen, Y; Zheng, Y; et al. Respiratory Research. 2018; 19.