A photo of Fukun Guo.

Fukun Guo, PhD

  • Member, Division of Experimental Hematology & Cancer Biology
  • Associate Professor, UC Department of Pediatrics

About

Biography

I joined Cincinnati Children’s Hospital Medical Center in 2002 after training as a molecular and cellular biologist. I have an extensive background and long-term interest in immunology. Currently, I investigate the role and mechanisms of Rho family GTPases in T lymphocyte development and function.

Since beginning my work, I helped discover the role of Rho GTPases in T lymphocyte metabolism, which is important for T lymphocyte-mediated autoimmunity and allergy. Also, I helped determine the role of Rho family GTPases in anti-tumor T cell immunity.

My research has consistently been supported by National Institutes of Health (NIH) awards. I am also a reviewer of NIH grants for others’ research projects.

BS: Jilin University, Changchun, Jilin, China, 1994.

MS: Academy of Military Medical Sciences, Beijing, China, 1997.

PhD: Southern Medical University, Guangzhou, Guangdong, China, 2000.

Postdoctoral Research Associate: University of Tennessee, Memphis, TN, 2000-2002; Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2002-2004.

Research Associate: Southern Medical University, Guangzhou, Guangdong, China, 2000; Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2004.

Research Instructor: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH. 2005-2009.

Interests

Rho GTPases and T and B lymphocyte development and function

Research Areas

Experimental Hematology and Cancer Biology, Cancer and Blood Diseases

Publications

Regulation of Cdc42 signaling by the dopamine D2 receptor in a mouse model of Parkinson's disease. Ying, L; Zhao, J; Ye, Y; Liu, Y; Xiao, B; Xue, T; Zhu, H; Wu, Y; He, J; Qin, S; et al. Aging Cell. 2022; 21.

Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity. Kalim, KW; Yang, JQ; Modur, V; Nguyen, P; Li, Y; Zheng, Y; Guo, F. Frontiers in Immunology. 2021; 12.

Crosstalk Between the Tumor Microenvironment and Cancer Cells: A Promising Predictive Biomarker for Immune Checkpoint Inhibitors. Li, X; Yang, Y; Huang, Q; Deng, Y; Guo, F; Wang, G; Liu, M. Frontiers in Cell and Developmental Biology. 2021; 9.

A Distinct Clinicopathological Feature and Prognosis of Young Gastric Cancer Patients Aged ≤ 45 Years Old. Huang, Q; Zheng, X; Jiao, Y; Lei, Y; Li, X; Bi, F; Guo, F; Wang, G; Liu, M. Frontiers in Oncology. 2021; 11.

RhoA and Cdc42 in T cells: Are they targetable for T cell-mediated inflammatory diseases?. Guo, F. Precision Clinical Medicine. 2021; 4:56-61.

Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition. Fan, C; Zhao, C; Zhang, F; Kesarwani, M; Tu, Z; Cai, X; Davis, AK; Xu, L; Hochstetler, CL; Chen, X; et al. Proceedings of the National Academy of Sciences of the United States of America. 2021; 118.

A Highlight of the Mechanisms of Immune Checkpoint Blocker Resistance. Huang, Q; Lei, Y; Li, X; Guo, F; Liu, M. Frontiers in Cell and Developmental Biology. 2020; 8.

Dopamine D1 and D2 Receptors Differentially Regulate Rac1 and Cdc42 Signaling in the Nucleus Accumbens to Modulate Behavioral and Structural Plasticity After Repeated Methamphetamine Treatment. Tu, G; Ying, L; Ye, L; Zhao, J; Liu, N; Li, J; Liu, Y; Zhu, M; Wu, Y; Xiao, B; et al. Biological Psychiatry. 2019; 86:820-835.

Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation. Yang, JQ; Kalim, KW; Li, Y; Zheng, Y; Guo, F. Journal of Leukocyte Biology. 2019; 106:1139-1151.

Inhibition of Rho-Kinase Downregulates Th17 Cells and Ameliorates Hepatic Fibrosis by Schistosoma japonicum Infection. Zhou, W; Yang, Y; Mei, C; Dong, P; Mu, S; Wu, H; Zhou, Y; Zheng, Y; Guo, F; Yang, J. Cells. 2019; 8.