A photo of Fukun Guo.

Fukun Guo, PhD

  • Member, Division of Experimental Hematology & Cancer Biology
  • Professor, UC Department of Pediatrics



I joined Cincinnati Children’s Hospital Medical Center in 2002 after training as a molecular and cellular biologist. I have an extensive background and long-term interest in immunology. Currently, I investigate the role and mechanisms of Rho family GTPases in T lymphocyte development and function.

Since beginning my work, I helped discover the role of Rho GTPases in T lymphocyte metabolism, which is important for T lymphocyte-mediated autoimmunity and allergy. Also, I helped determine the role of Rho family GTPases in anti-tumor T cell immunity.

My research has consistently been supported by National Institutes of Health (NIH) awards. I am also a reviewer of NIH grants for others’ research projects.

BS: Jilin University, Changchun, Jilin, China, 1994.

MS: Academy of Military Medical Sciences, Beijing, China, 1997.

PhD: Southern Medical University, Guangzhou, Guangdong, China, 2000.

Postdoctoral Research Associate: University of Tennessee, Memphis, TN, 2000-2002; Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2002-2004.

Research Associate: Southern Medical University, Guangzhou, Guangdong, China, 2000; Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2004.

Research Instructor: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH. 2005-2009.


Rho GTPases and T and B lymphocyte development and function

Research Areas

Experimental Hematology and Cancer Biology, Cancer and Blood Diseases


Cdc42GAP deficiency contributes to the Alzheimer's disease phenotype. Zhu, M; Xiao, B; Xue, T; Qin, S; Ding, J; Wu, Y; Tang, Q; Huang, M; Zhao, N; Ye, Y; et al. Brain: a journal of neurology. 2023; 146:4350-4365.

Kinase-independent role of mTOR and on-/off-target effects of an mTOR kinase inhibitor. Fan, C; Wunderlich, M; Cai, X; Yan, Z; Zhang, F; Davis, AK; Xu, L; Guo, F; Lu, QR; Azam, M; et al. Leukemia. 2023; 37:2073-2081.

Mechanism of inert inflammation in an immune checkpoint blockade-resistant tumor subtype bearing transcription elongation defects. Modur, V; Muhammad, B; Yang, JQ; Zheng, Y; Komurov, K; Guo, F. Cell Reports. 2023; 42:112364.

Cdc42 signaling regulated by dopamine D2 receptor correlatively links specific brain regions of hippocampus to cocaine addiction. Li, J; Wu, Y; Xue, T; He, J; Zhang, L; Liu, Y; Zhao, J; Chen, Z; Xie, M; Xiao, B; et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 2023; 1869:166569.

Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity. Kalim, KW; Yang, JQ; Wunderlich, M; Modur, V; Nguyen, P; Li, Y; Wen, T; Davis, AK; Verma, R; Lu, QR; et al. Journal for ImmunoTherapy of Cancer. 2022; 10:e004806.

Tumors bearing defective transcription elongation are immune hot but resistant to immune checkpoint inhibitors. Modur, V; Guo, F. Journal of immunology (Baltimore, Md. : 1950). 2022; 208:119.11.

Regulation of Cdc42 signaling by the dopamine D2 receptor in a mouse model of Parkinson's disease. Ying, L; Zhao, J; Ye, Y; Liu, Y; Xiao, B; Xue, T; Zhu, H; Wu, Y; He, J; Qin, S; et al. Aging Cell. 2022; 21:e13588.

Human Spinal Organoid-on-a-Chip to Model Nociceptive Circuitry for Pain Therapeutics Discovery. Ao, Z; Cai, H; Wu, Z; Krzesniak, J; Tian, C; Lai, YY; Mackie, K; Guo, F. Analytical Chemistry. 2022; 94:1365-1372.

Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity. Kalim, KW; Yang, JQ; Modur, V; Nguyen, P; Li, Y; Zheng, Y; Guo, F. Frontiers in Immunology. 2021; 12:726393.

Crosstalk Between the Tumor Microenvironment and Cancer Cells: A Promising Predictive Biomarker for Immune Checkpoint Inhibitors. Li, X; Yang, Y; Huang, Q; Deng, Y; Guo, F; Wang, G; Liu, M. Frontiers in Cell and Developmental Biology. 2021; 9:738373.