Fukun Guo, PhD

Member, Division of Experimental Hematology & Cancer Biology
Professor, UC Department of Pediatrics

fukun.guo@cchmc.org

About

Biography

I joined Cincinnati Children’s Hospital Medical Center in 2002 after training as a molecular and cellular biologist. I have an extensive background and long-term interest in immunology. Currently, I investigate the role and mechanisms of Rho family GTPases in T lymphocyte development and function.

Since beginning my work, I helped discover the role of Rho GTPases in T lymphocyte metabolism, which is important for T lymphocyte-mediated autoimmunity and allergy. Also, I helped determine the role of Rho family GTPases in anti-tumor T cell immunity.

My research has consistently been supported by National Institutes of Health (NIH) awards. I am also a reviewer of NIH grants for others’ research projects.

Services and Specialties

Interests

Rho GTPases and T and B lymphocyte development and function

Research Areas

Cancer and Blood Diseases

Publications

ZMYND11 functions in bimodal regulation of latent genes and brain-like splicing to safeguard corticogenesis. Chang, X; Li, W; Matsui, S; Huynh, C; Erickson, C; Guo, F; Cederquist, GY; Studer, L; Iwafuchi, M; Shillington, A; Chronis, C; Tchieu, J. Nature Communications. 2025; 16:9010.

Intelligent sensing devices and systems for personalized mental health. Xing, Y; Yang, Y; Yang, K; Lu, A; Xing, L; Mackie, K; Guo, F. 2025; 3:10.

Genetic and epigenetic regulation of Treg cell fitness by autism-related chromatin remodeler CHD8. Yang, JQ; Wang, C; Nayak, RC; Kolla, M; Cai, M; Pujato, M; Zheng, Y; Lu, QR; Guo, F. Cellular and Molecular Biology Letters: an international journal. 2025; 30:36.

Tumor-derived RAC1A159V mutation promotes an immunosuppressive microenvironment that represses response to immune checkpoint inhibitor. Cai, M; Adam, M; Duan, X; Guo, F; Zheng, Y. Science Advances. 2025; 11:eaea1212.

Understanding monocyte-driven neuroinflammation in Alzheimer's disease using human cortical organoid microphysiological systems. Tian, C; Ao, Z; Cerneckis, J; Cai, H; Chen, L; Niu, H; Takayama, K; Kim, J; Shi, Y; Gu, M; Kanekiyo, T; Guo, F. Science Advances. 2025; 11:eadu2708.

Current Advances and Future Directions for Sensitizing Gastric Cancer to Immune Checkpoint Inhibitors. Li, W; Xu, M; Cheng, M; Wei, J; Zhu, L; Deng, Y; Guo, F; Bi, F; Liu, M. Cancer Medicine. 2025; 14:e71065.

Abstract 1596: Tumor-derived RAC1A159V gain-of-function mutation promotes an immunosuppressive tumor microenvironment and represses response to immune checkpoint inhibitors. Cai, M; Adam, M; Guo, F; Zheng, Y. Cancer Research. 2025; 85:1596.

Current trends in sensitizing immune checkpoint inhibitors for cancer treatment. Wei, J; Li, W; Zhang, P; Guo, F; Liu, M. Molecular Cancer. 2024; 23:279.

Autism-related CHD8 is required for maintaining Treg cell fitness. Yang, J; Zheng, Y; Guo, F. Journal of immunology (Baltimore, Md. : 1950). 2024; 212:1217_5681.

Efficacy and advantage of immunotherapy for melanoma via intramuscular co-expression of plasmid-encoded PD-1 and CTLA-4 scFvs. Yang, Y; Huang, Q; Cheng, M; Deng, L; Liu, X; Zheng, X; Wei, J; Lei, Y; Li, X; Guo, F; Deng, Y; Zheng, Y; Bi, F; Wang, G; Liu, M. AMERICAN JOURNAL OF CANCER RESEARCH. 2024; 14:2626-2642.