A photo of Fukun Guo.

Member, Division of Experimental Hematology & Cancer Biology

Associate Professor, UC Department of Pediatrics


Biography & Affiliation


I joined Cincinnati Children’s Hospital Medical Center in 2002 after training as a molecular and cellular biologist. I have an extensive background and long-term interest in immunology. Currently, I investigate the role and mechanisms of Rho family GTPases in T lymphocyte development and function.

Since beginning my work, I helped discover the role of Rho GTPases in T lymphocyte metabolism, which is important for T lymphocyte-mediated autoimmunity and allergy. Also, I helped determine the role of Rho family GTPases in anti-tumor T cell immunity.

My research has consistently been supported by National Institutes of Health (NIH) awards. I am also a reviewer of NIH grants for others’ research projects.

Research Interests

Rho GTPases and T and B lymphocyte development and function

Academic Affiliation

Associate Professor, UC Department of Pediatrics

Research Divisions

Experimental Hematology and Cancer Biology, Cancer and Blood Diseases


BS: Jilin University, Changchun, Jilin, China, 1994.

MS: Academy of Military Medical Sciences, Beijing, China, 1997.

PhD: Southern Medical University, Guangzhou, Guangdong, China, 2000.

Postdoctoral Research Associate: University of Tennessee, Memphis, TN, 2000-2002; Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2002-2004.

Research Associate: Southern Medical University, Guangzhou, Guangdong, China, 2000; Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2004.

Research Instructor: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH. 2005-2009.


A Highlight of the Mechanisms of Immune Checkpoint Blocker Resistance. Huang, Q; Lei, Y; Li, X; Guo, F; Liu, M. Frontiers in Cell and Developmental Biology. 2020; 8.

Dopamine D1 and D2 Receptors Differentially Regulate Rac1 and Cdc42 Signaling in the Nucleus Accumbens to Modulate Behavioral and Structural Plasticity After Repeated Methamphetamine Treatment. Tu, G; Ying, L; Ye, L; Zhao, J; Liu, N; Li, J; Liu, Y; Zhu, M; Wu, Y; Xiao, B; et al. Biological Psychiatry. 2019; 86:820-835.

Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation. Yang, JQ; Kalim, KW; Li, Y; Zheng, Y; Guo, F. Journal of Leukocyte Biology. 2019; 106:1139-1151.

Inhibition of Rho-Kinase Downregulates Th17 Cells and Ameliorates Hepatic Fibrosis by Schistosoma japonicum Infection. Zhou, W; Yang, Y; Mei, C; Dong, P; Mu, S; Wu, H; Zhou, Y; Zheng, Y; Guo, F; Yang, J. Cells. 2019; 8:1262-1262.

Rational Targeting of Cdc42 Overcomes Drug Resistance of Multiple Myeloma. Nguyen, P; Chakrabarti, J; Li, Y; Kalim, KW; Zhang, M; Zhang, L; Zheng, Y; Guo, F. Frontiers in Oncology. 2019; 9.

Schistosoma japonicum infection downregulates house dust mite-induced allergic airway inflammation in mice. Qiu, S; Fan, X; Yang, Y; Dong, P; Zhou, W; Xu, Y; Zhou, Y; Guo, F; Zheng, Y; Yang, J. PLoS ONE. 2019; 12:e0179565-e0179565.

Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization. Liu, W; Du, W; Shang, X; Wang, L; Evelyn, C; Florian, MC; Ryan, MA; Rayes, A; Zhao, X; Setchell, K; et al. Leukemia. 2019; 33:749-761.

Rational targeting Cdc42 restrains Th2 cell differentiation and prevents allergic airway inflammation. Yang, J; Kalim, KW; Li, Y; Duan, X; Nguyen, P; Hershey, GK K; Kroner, J; Ruff, B; Zhang, L; Salomonis, N; et al. Clinical and Experimental Allergy. 2019; 49:92-107.

mDia1 and Cdc42 Regulate Activin B-Induced Migration of Bone Marrow-Derived Mesenchymal Stromal Cells. Wang, X; Tang, P; Guo, F; Zhang, M; Yan, Y; Huang, M; Chen, Y; Zhang, L; Zhang, L. Stem Cells. 2019; 37:150-162.

Cdc42 Deficiency Leads To Epidermal Barrier Dysfunction by Regulating Intercellular Junctions and Keratinization of Epidermal Cells during Mouse Skin Development. Zhang, M; Wang, X; Guo, F; Jia, Q; Liu, N; Chen, Y; Yan, Y; Huang, M; Tang, H; Deng, Y; et al. Theranostics. 2019; 9:5065-5084.