A photo of Hartmut Geiger.

Director, Comprehensive Mouse and Cancer Core

Professor, UC Department of Pediatrics

513-636-1338

513-636-3768

Biography & Affiliation

Clinical Interests

Hematopoietic stem cells; genetics; aging/longevity; plasticity of stem cells; mobilization; DNA-repair.

Academic Affiliation

Professor, UC Department of Pediatrics

Divisions

Experimental Hematology and Cancer Biology, Cancer and Blood Diseases

Education

MS: Studies in chemistry at the University Karlsruhe, Germany and studies in biochemistry at the University Witten/Herdecke, Germany, 1996.

PhD: Max-Planck Institut für Immunbiologie in Freiburg, Germany. Plasticity of murine hematopoietic stem cells, 1999.

Postdoctoral Studies: University of Kentucky, Lexington, USA. Genetic analysis of hematopoiesis and aging/longevity in mice.

Publications

Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance. Zhang, C; Fondufe-Mittendorf, YN; Wang, C; Chen, J; Cheng, Q; Zhou, D; Zheng, Y; Geiger, H; Liang, Y. Haematologica: the hematology journal. 2020; 105:573-584.

The lifespan quantitative trait locus gene Securin controls hematopoietic progenitor cell function. Brown, A; Schuetz, D; Han, Y; Daria, D; Nattamai, KJ; Eiwen, K; Sakk, V; Pospiech, J; Saller, T; van Zant, G; et al. Haematologica: the hematology journal. 2020; 105:317-324.

Functional and clinical characterization of the alternatively spliced isoform AML1-ETO9a in adult patients with translocation t(8;21)(q22;q22.1) acute myeloid leukemia (AML). Agrawal, M; Schwarz, P; Giaimo, BD; Bedzhov, I; Corbacioglu, A; Weber, D; Gaidzik, VI; Jahn, N; Ruecker, FG; Schroeder, T; et al. Leukemia. 2020; 34:630-634.

HPRT and Purine Salvaging Are Critical for Hematopoietic Stem Cell Function. Vogel, M; Moehrle, B; Brown, A; Eiwen, K; Sakk, V; Geiger, H. Stem Cells. 2019; 37:1606-1614.

Haematopoietic stem cells in perisinusoidal niches are protected from ageing. Sacma, M; Pospiech, J; Bogeska, R; de Back, W; Mallm, J; Sakk, V; Soller, K; Marka, G; Vollmer, A; Karns, R; et al. Nature Cell Biology. 2019; 21:1309-1320.

KRasG12D expression in the bone marrow vascular niche affects hematopoiesis with inflammatory signals. Hochstetler, CL; Feng, Y; Sacma, M; Davis, AK; Rao, M; Kuan, C; You, L; Geiger, H; Zheng, Y. Experimental Hematology. 2019; 79:3-15.e4.

Hematopoietic Stem Cell Dynamics Are Regulated by Progenitor Demand: Lessons from a Quantitative Modeling Approach. Klose, M; Florian, MC; Gerbaulet, A; Geiger, H; Glauche, I. Stem Cells. 2019; 37:948-957.

DISTINCT DYNAMICS OF STEM AND PROGENITOR CELLS IN BLOOD OF POLYTRAUMATIZED PATIENTS. Vogel, M; Christow, H; Manz, I; Denkinger, M; Amoah, A; Schuetz, D; Brown, A; Moehrle, B; Schaffer, A; Kalbitz, M; et al. Shock. 2019; 51:430-438.

Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization. Liu, W; Du, W; Shang, X; Wang, L; Evelyn, C; Florian, MC; Ryan, MA; Rayes, A; Zhao, X; Setchell, K; et al. Leukemia. 2019; 33:749-761.

Impaired immune surveillance accelerates accumulation of senescent cells and aging. Ovadya, Y; Landsberger, T; Leins, H; Vadai, E; Gal, H; Biran, A; Yosef, R; Sagiv, A; Agrawal, A; Shapira, A; et al. Nature Communications. 2018; 9.