A photo of Hartmut Geiger.

Director, Comprehensive Mouse and Cancer Core

Professor, UC Department of Pediatrics

513-636-1338

513-636-3768

Biography & Affiliation

Clinical Interests

Hematopoietic stem cells; genetics; aging/longevity; plasticity of stem cells; mobilization; DNA-repair.

Academic Affiliation

Professor, UC Department of Pediatrics

Departments

Experimental Hematology and Cancer Biology, Cancer and Blood Diseases

Education

MS: Studies in chemistry at the University Karlsruhe, Germany and studies in biochemistry at the University Witten/Herdecke, Germany, 1996.

PhD: Max-Planck Institut für Immunbiologie in Freiburg, Germany. Plasticity of murine hematopoietic stem cells, 1999.

Postdoctoral Studies: University of Kentucky, Lexington, USA. Genetic analysis of hematopoiesis and aging/longevity in mice.

Publications

Hematopoietic Stem Cell Dynamics Are Regulated by Progenitor Demand: Lessons from a Quantitative Modeling Approach. Klose, M; Florian, MC; Gerbaulet, A; Geiger, H; Glauche, I. Stem Cells. 2019; 37:948-957.

DISTINCT DYNAMICS OF STEM AND PROGENITOR CELLS IN BLOOD OF POLYTRAUMATIZED PATIENTS. Vogel, M; Christow, H; Manz, I; Denkinger, M; Amoah, A; Schuetz, D; Brown, A; Moehrle, B; Schaffer, A; Kalbitz, M; et al. Shock. 2019; 51:430-438.

Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization. Liu, W; Du, W; Shang, X; Wang, L; Evelyn, C; Florian, MC; Ryan, MA; Rayes, A; Zhao, X; Setchell, K; et al. Leukemia. 2019; 33:749-761.

Impaired immune surveillance accelerates accumulation of senescent cells and aging. Ovadya, Y; Landsberger, T; Leins, H; Vadai, E; Gal, H; Biran, A; Yosef, R; Sagiv, A; Agrawal, A; Shapira, A; et al. Nature Communications. 2018; 9.

LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells. Grigoryan, A; Guidi, N; Senger, K; Liehr, T; Soller, K; Marka, G; Vollmer, A; Markaki, Y; Leonhardt, H; Buske, C; et al. Genome Biology: biology for the post-genomic era. 2018; 19.

Chromosome integrity checkpoints in stem and progenitor cells: transitions upon differentiation, pathogenesis, and aging. Brown, A; Geiger, H. Cellular and Molecular Life Sciences. 2018; 75:3771-3779.

Aging alters the epigenetic asymmetry of HSC division. Florian, MC; Klose, M; Sacma, M; Jablanovic, J; Knudson, L; Nattamai, KJ; Marka, G; Vollmer, A; Soller, K; Sakk, V; et al. PLoS Biology. 2018; 16:e2003389-e2003389.

A non-myeloablative conditioning approach for long-term engraftment of human and mouse hematopoietic stem cells. Du, W; Liu, W; Mizukawa, B; Shang, X; Sipple, J; Wunderlich, M; Geiger, H; Davies, S; Mulloy, J; Pang, Q; et al. Leukemia. 2018; 32:2041-2046.

Epigenetic age-predictor for mice based on three CpG sites. Han, Y; Eipel, M; Franzen, J; Sakk, V; Dethmers-Ausema, B; Yndriago, L; Izeta, A; de Haan, G; Geiger, H; Wagner, W. eLife. 2018; 7.

Aged murine hematopoietic stem cells drive aging-associated immune remodeling. Leins, H; Mulaw, M; Eiwen, K; Sakk, V; Liang, Y; Denkinger, M; Geiger, H; Schirmbeck, R. Blood. 2018; 132:565-576.