A photo of James Geller.

James I. Geller, MD

  • Director - Liver, Kidney and Retinoblastoma Programs, Cancer and Blood Diseases Institute
  • Director, Advanced Cancer Therapy Network, Cancer and Blood Disease Institute
  • Director, Pilot Translational Core Grant Program, Center for Clinical and Translational Science and Training
  • Professor, UC Department of Pediatrics



James I. Geller, MD, started in the Division of Oncology at Cincinnati Children's Hospital Medical Center as an assistant professor within the UC Department of Pediatrics in 2004. Currently, he is the medical director of Liver and Renal Tumor Programs and co-director of the Retinoblastoma Program.

His primary academic interest is the development of novel therapy options for infants, children, adolescents and young adults with solid tumors. At the institutional level, he achieves this through direct patient care and by leading our teams in clinical and research efforts in my specialty areas at Cincinnati Children’s Hospital Medical Center. At the national level, he participates as a member of the Children’s Oncology Group (COG) Renal Tumor (RTC), Liver Tumor, Retinoblastoma and Central Nervous System Committees; He functions as vice chair for the RTC and liaison to the COG Developmental Therapeutics Committee (DVL) and Pediatric Preclinical Testing Program as well as chair both the RTC Developmental Therapeutics Working Group and the COG High Risk Renal Tumors Protocols including AREN1721 (focused on immunotherapy and anti-angiogenic therapy for TFE Renal Cell Carcinoma), AREN1921 (focused on relapsed and anaplastic Wilms tumor), and has drafted the next concept for study of epigenetic therapy plus chemotherapy for treatment of rhabdoid tumor. He also serves as co-chair of the COG liver tumor protocol, the Pediatric Hepatic International Tumor Trial (PHITT); AHEP1531.

It is his goal to help facilitate the development of novel therapy for young patients affected with solid tumors. Current areas of expansion include the establishment of the Translational RCC Research Initiatives including a registry for TFE RCC, and development of data harmonization and treatment optimization for relapsed pediatric liver cancers. Integration of cellular and immunotherapy, as well as novel interventional therapeutics, remains a priority.

BA: Chemistry, Dartmouth College, Hanover, NH. 

MD: Sackler School of Medicine, Tel Aviv University, 1997.

Residency: Pediatrics, New York Medical College, 2000.

Fellowship: Pediatric Hematology/Oncology, St Jude Children's Research Hospital, 2004.

Certification: Pediatrics, 2000, 2007; Pediatric Hematology/Oncology, 2005.


Pediatric oncology; solid tumors; liver tumors; kidney tumors; retinoblastoma; rare tumors; intraarterial chemotherapy and intraarterial radiotherapy for treatment of select cancers

Services and Specialties

Cancer and Blood Diseases, Kidney Tumor, Liver Tumor, Pancreas Care


Liver tumors; kidney tumors; retinoblastoma; new drug development; novel interventional therapeutics: intra-arterial chemotherapy, intra-arterial radiotherapy, high intensity focused ultrasound (HIFU)

Research Areas

Oncology, Cancer and Blood Diseases

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Feasibility of using CT volume as a predictor of specimen weight in a subgroup of patients with low risk Wilms tumors registered on COG Study AREN03B2: implications for central venous catheter placement. Ferrer, FA; Herbst, KW; Fernandez, CV; Khanna, G; Dome, JS; Naranjo, A; Mullen, EA; Geller, JI; Gratias, EJ; Shamberger, R; et al. Journal of Pediatric Urology. 2014; 10:969-973.


Detection of preoperative wilms tumor rupture with CT: a report from the Children's Oncology Group. Khanna, G; Naranjo, A; Hoffer, F; Mullen, E; Geller, J; Gratias, EJ; Ehrlich, PF; Perlman, EJ; Rosen, N; Grundy, P; et al. Radiology. 2013; 266:610-617.


Detection of preoperative wilms tumor rupture with CT: a report from the Children's Oncology Group. Khanna, G; Naranjo, A; Hoffer, F; Mullen, E; Geller, J; Gratias, EJ; Ehrlich, PF; Perlman, EJ; Rosen, N; Grundy, P; et al. Radiology. 2013; 266:610-617.

β-catenin cancer-enhancing genomic regions axis is involved in the development of fibrolamellar hepatocellular carcinoma. Gulati, R; Johnston, M; Rivas, M; Cast, A; Kumbaji, M; Hanlon, MA; Lee, S; Zhou, P; Lake, C; Schepers, E; et al. Hepatology Communications. 2022; 6:2950-2963.

Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults. Sumazin, P; Peters, TL; Sarabia, SF; Kim, HR; Urbicain, M; Hollingsworth, EF; Alvarez, KR; Perez, CR; Pozza, A; Najaf Panah, MJ; et al. Journal of Hepatology. 2022; 77:1026-1037.

Pediatric Renal Tumors. Geller, JI; Vandenheuval, K; Smith, E; Kotagal, M; Pater, L. Pediatric Nephrology. : Springer Nature; Springer Nature; 2022.

Skeletal muscle mass as a marker to predict outcomes in children and young adults with cancer. McBee, MP; Woodhouse, C; Trout, AT; Geller, JI; Smith, EA; Zhang, B; Towbin, AJ. Abdominal Radiology. 2022; 47:452-459.

Identification of distinct tumor cell populations and key genetic mechanisms through single cell sequencing in hepatoblastoma. Bondoc, A; Glaser, K; Jin, K; Lake, C; Cairo, S; Geller, J; Tiao, G; Aronow, B. Communications Biology. 2021; 4:1049.

Comparison of 0.3-mSv CT to Standard-Dose CT for Detection of Lung Nodules in Children and Young Adults With Cancer. Thapaliya, S; Gilligan, LA; Brady, SL; Anton, CG; Crotty, EJ; Nasser, MP; Geller, JI; Pressey, JG; Zhang, B; Dillman, JR; et al. American Journal of Roentgenology. 2021; 217:1444-1451.

Olaparib Inhibits Tumor Growth of Hepatoblastoma in Patient-Derived Xenograft Models. Johnston, ME; Rivas, MP; Nicolle, D; Gorse, A; Gulati, R; Kumbaji, M; Weirauch, MT; Bondoc, A; Cairo, S; Geller, J; et al. Hepatology. 2021; 74:2201-2215.

From the Blog

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Surgery for a Child with Trisomy 18

James I. Geller, MD, David S. Cooper, MD, MPH ...3/20/2022

Hepatoblastoma in Kids: Most Frequently Asked Questions
Blog Cancer and Blood Diseases

Hepatoblastoma in Kids: Most Frequently Asked Questions

By James Geller, MD3/27/2019

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