A photo of David Hartley.

David M. Hartley, PhD, MPH

  • Associate Professor, UC Department of Pediatrics



My research work investigates the factors governing the emergence and transmission of infectious diseases by applying mathematical modeling, computer simulation and data analytic approaches. I strive to use team-based, interdisciplinary research to improve child health.

A background in applied physics and mathematics led me to begin using math and computer simulation to better understand the HIV epidemic in the early 1990s. That interest grew into mathematical disease ecology and research on how environmental variables affect the emergence and spread of different infectious diseases. Interest in public health surveillance followed from my study of epidemics.

I also study the spread of ideas and cooperation in learning healthcare systems using mathematical tools like those applied to measuring and modeling epidemics.

My current research projects include:

  • Surveillance of antibiotic resistant and other emerging infectious diseases, including COVID-19
  • Development and understanding of collaborative learning health systems
  • Innovative uses of electronic health record (EHR) data for diverse health stakeholders
  • Actionable, large-scale collection and analysis of unstructured data, so called “big data,” for early warnings of epidemics and infectious disease situational awareness

I have served on numerous review, advisory and expert panels, including a 2003 White House Blue Ribbon Panel charged with addressing the threat of bioterrorism directed against livestock. From 2008 to 2014, I served on a working group for the Department of Homeland Security and National Institutes of Health (DHS-NIH) Research and Policy for Infectious Disease Dynamics (RAPIDD). I have also been elected to senior membership in the Institute of Electrical and Electronics Engineers (IEEE).


Testing the Use of Data Drawn from the Electronic Health Record to Compare Quality. Walsh, KE; Razzaghi, H; Hartley, DM; Utidjian, L; Alford, S; Darwar, RA; Shenkman, E; Jonas, S; Goodick, M; Finkelstein, J; et al. Pediatric Quality and Safety. 2021; 6.

Collaborative learning health systems: Science and practice. Hartley, DM; Seid, M. Learning Health Systems. 2021; 5.

A collaborative learning health system agent-based model: Computational and face validity. Seid, M; Bridgeland, D; Bridgeland, A; Hartley, DM. Learning Health Systems. 2021; 5.

Getting what is needed, when it's needed: Sharing information, knowledge, and know-how in a Collaborative Learning Health System. Keck, C; Hartley, DM; Havens, M; Margolis, PA; Seid, M. Learning Health Systems. 2021; 5.

A science of collaborative learning health systems. Seid, M; Hartley, DM; Margolis, PA. Learning Health Systems. 2021; 5.

Measuring engagement in a collaborative learning health system: The case of ImproveCareNow. Hartley, DM; Keck, C; Havens, M; Margolis, PA; Seid, M. Learning Health Systems. 2021; 5.

Rapid, Bottom-Up Design of a Regional Learning Health System in Response to COVID-19. Beck, AF; Hartley, DM; Kahn, RS; Taylor, SC; Bishop, E; Rich, K; Saeed, MS; Schuler, CL; Seid, M; Cronin, SC; et al. Mayo Clinic Proceedings. 2021; 96:849-855.

Association Between Statewide School Closure and COVID-19 Incidence and Mortality in the US. Auger, KA; Shah, SS; Richardson, T; Hartley, D; Hall, M; Warniment, A; Timmons, K; Bosse, D; Ferris, SA; Brady, PW; et al. JAMA - Journal of the American Medical Association. 2020; 324:859-870.

When infection prevention enters the temple: Intergenerational social distancing and COVID-19. Hartley, DM; Reisinger, HS; Perencevich, EN. Infection Control and Hospital Epidemiology. 2020; 41:868-869.

Addressing the Impact of the Coronavirus Disease 2019 (COVID-19) Pandemic on Hematopoietic Cell Transplantation: Learning Networks as a Means for Sharing Best Practices. Ardura, M; Hartley, D; Dandoy, C; Lehmann, L; Jaglowski, S; Auletta, JJ; Bhatt, N; Huber, J; Juckett, MB; Mueller, M; et al. Biology of Blood and Marrow Transplantation. 2020; 26:e147-e160.