A photo of David Hartley.

Associate Professor, UC Department of Pediatrics


Biography & Affiliation


My research work investigates the factors governing the emergence and transmission of infectious diseases by applying mathematical modeling, computer simulation and data analytic approaches. I strive to use team-based, interdisciplinary research to improve child health.

A background in applied physics and mathematics led me to begin using math and computer simulation to better understand the HIV epidemic in the early 1990s. That interest grew into mathematical disease ecology and research on how environmental variables affect the emergence and spread of different infectious diseases. Interest in public health surveillance followed from my study of epidemics.

I also study the spread of ideas and cooperation in learning healthcare systems using mathematical tools like those applied to measuring and modeling epidemics.

My current research projects include:

  • Surveillance of antibiotic resistant and other emerging infectious diseases, including COVID-19
  • Development and understanding of collaborative learning health systems
  • Innovative uses of electronic health record (EHR) data for diverse health stakeholders
  • Actionable, large-scale collection and analysis of unstructured data, so called “big data,” for early warnings of epidemics and infectious disease situational awareness

I have served on numerous review, advisory and expert panels, including a 2003 White House Blue Ribbon Panel charged with addressing the threat of bioterrorism directed against livestock. From 2008 to 2014, I served on a working group for the Department of Homeland Security and National Institutes of Health (DHS-NIH) Research and Policy for Infectious Disease Dynamics (RAPIDD). I have also been elected to senior membership in the Institute of Electrical and Electronics Engineers (IEEE).

Research Interests

Infectious disease epidemiology; public health surveillance; mathematical and computer modeling

Academic Affiliation

Associate Professor, UC Department of Pediatrics

Research Divisions

Quality Improvement, Biostatistics and Epidemiology, Infectious Diseases


PhD: University of Maryland Baltimore County, Baltimore, MD, 1996.

MPH: George Washington University, Washington, DC, 2006.


Association Between Statewide School Closure and COVID-19 Incidence and Mortality in the US. Auger, KA; Shah, SS; Richardson, T; Hartley, D; Hall, M; Warniment, A; Timmons, K; Bosse, D; Ferris, SA; Brady, PW; et al. JAMA - Journal of the American Medical Association. 2020; 324:859-870.

When infection prevention enters the temple: Intergenerational social distancing and COVID-19. Hartley, DM; Reisinger, HS; Perencevich, EN. Infection Control and Hospital Epidemiology. 2020; 41:868-869.

Addressing the Impact of the Coronavirus Disease 2019 (COVID-19) Pandemic on Hematopoietic Cell Transplantation: Learning Networks as a Means for Sharing Best Practices. Ardura, M; Hartley, D; Dandoy, C; Lehmann, L; Jaglowski, S; Auletta, JJ; Bhatt, N; Huber, J; Juckett, MB; Mueller, M; et al. Biology of Blood and Marrow Transplantation. 2020; 26:e147-e160.

Public Health Interventions for COVID-19: Emerging Evidence and Implications for an Evolving Public Health Crisis. Hartley, DM; Perencevich, EN. JAMA - Journal of the American Medical Association. 2020; 323:1908-1909.

Use of EHR-Based Pediatric Quality Measures: Views of Health System Leaders and Parents. Hartley, DM; Jonas, S; Grossoehme, D; Kelly, A; Dodds, C; Alford, SM; Shenkman, E; Simmons, J; Bailey, LC; Razzaghi, H; et al. American Journal of Medical Quality. 2020; 35:177-185.

Organizing for collaboration: An actor-oriented architecture in ImproveCareNow. Seid, M; Hartley, DM; Dellal, G; Myers, S; Margolis, PA. Learning Health Systems. 2020; 4.

Carbapenem and colistin resistance in Enterobacteriaceae in Southeast Asia: Review and mapping of emerging and overlapping challenges. Malchione, MD; Torres, LM; Hartley, DM; Koch, M; Goodman, JL. International Journal of Antimicrobial Agents. 2019; 54:381-399.

The Role of Event-Based Biosurveillance in Biodefense. Hartley, DM; Mui, W; Corley, CD. Defense Against Biological Attacks. 2019.

Review and mapping of carbapenem-resistant Enterobacteriaceae in Africa: Using diverse data to inform surveillance gaps. Mitgang, EA; Hartley, DM; Malchione, MD; Koch, M; Goodman, JL. International Journal of Antimicrobial Agents. 2018; 52:372-384.

Coughing, sneezing, and aching online: Twitter and the volume of influenza-like illness in a pediatric hospital. Hartley, DM; Giannini, CM; Wilson, S; Frieder, O; Margolis, PA; Kotagal, UR; White, DL; Connelly, BL; Wheeler, DS; Tadesse, DG; et al. PLoS ONE. 2017; 12.