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Adjunct Associate Professor, UC Department of Pediatrics


Biography & Affiliation

Academic Affiliation

Adjunct Associate Professor, UC Department of Pediatrics


Molecular Immunology, Immunobiology


BS: Biology; Utrecht University, The Netherlands, 1994.

PhD: Immunology/ Pharmacology; Utrecht University, The Netherlands, 2001.


Loss of GTPase of immunity-associated protein 5 (Gimap5) promotes pathogenic CD4(+) T-cell development and allergic airway disease. Patterson, AR; Bolcas, P; Lampe, K; Cantrell, R; Ruff, B; Lewkowich, I; Hogan, SP; Janssen, EM; Bleesing, J; Hershey, GK K; et al. Journal of Allergy and Clinical Immunology. 2019; 143:245-257.e6.

Gimap5-dependent inactivation of GSK3 beta is required for CD4(+) T cell homeostasis and prevention of immune pathology. Patterson, AR; Endale, M; Lampe, K; Aksoylar, HI; Flagg, A; Woodgett, JR; Hildeman, D; Jordan, MB; Singh, H; Kucuk, Z; et al. Nature Communications. 2018; 9.

The Emerging Role of CD244 Signaling in Immune Cells of the Tumor Microenvironment. Agresta, L; Hoebe, KH N; Janssen, EM. Frontiers in Immunology. 2018; 9.

Peroxisomal beta-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease. Moreno-Fernandez, ME; Giles, DA; Stankiewicz, TE; Sheridan, R; Karns, R; Cappelletti, M; Lampe, K; Mukherjee, R; Sina, C; Sallese, A; et al. JCI insight. 2018; 3.

Lipopolysaccharide suppresses IgE-mast cell-mediated reactions. Wang, N; McKell, M; Dang, A; Yamani, A; Waggoner, L; Vanoni, S; Noah, T; Wu, D; Kordowski, A; Koehl, J; et al. Clinical and Experimental Allergy. 2017; 47:1574-1585.

An ENU-induced splice site mutation of mouse Col1a1 causing recessive osteogenesis imperfecta and revealing a novel splicing rescue. Tabeta, K; Du, X; Arimatsu, K; Yokoji, M; Takahashi, N; Amizuka, N; Hasegawa, T; Crozat, K; Maekawa, T; Miyauchi, S; et al. Scientific Reports. 2017; 7.

Type I interferons regulate susceptibility to inflammation-induced preterm birth. Cappelletti, M; Presicce, P; Lawson, MJ; Chaturvedi, V; Stankiewicz, TE; Vanoni, S; Harley, IT W; McAlees, JW; Giles, DA; Moreno-Fernandez, ME; et al. JCI insight. 2017; 2.

Myeloid-derived NF-kappa B negative regulation of PU.1 and c/EBP-beta-driven pro-inflammatory cytokine production restrains LPS-induced shock. Vanoni, S; Tsai, Y; Waddell, A; Waggoner, L; Klarquist, J; Divanovic, S; Hoebe, K; Steinbrecher, KA; Hogan, SP. Innate Immunity. 2017; 23:175-187.

A mutation within the SH2 domain of slp-76 regulates the tissue distribution and cytokine production of iNKT cells in mice. Danzer, C; Koller, A; Baier, J; Arnold, H; Giessler, C; Opoka, R; Schmidt, S; Willers, M; Mihai, S; Parsch, H; et al. European Journal of Immunology. 2016; 46:2121-2136.

TCR and IL-7 Signaling Are Altered in the Absence of Functional GTPase of the Immune Associated Nucleotide Binding Protein 5 (GIMAP5). Chen, X; Serrano, D; Ghobadi, F; Mayhue, M; Hoebe, K; Ilangumaran, S; Ramanathan, S. PLoS ONE. 2016; 11:e0151837-e0151837.