A photo of Paul Horn.

Paul S. Horn, PhD

  • Biostatistician, Division of Neurology
  • Professor, UC Department of Pediatrics



My area of research is statistical analysis and how to apply general statistical methodology to specific pediatric problems. I want to improve statistical analysis in pediatrics to provide more reliable evidence for decision making.

I am interested in providing answers to questions regarding the statistical methodology that applies to pediatric populations, such as appropriate reference ranges. One of my achievements is the development of quantile estimators that are relatively robust for smaller sample sizes.

I am a member of the International Committee for the Clinical and Laboratory Standards Institute. My career spans more 39 years, and I have worked at Cincinnati Children’s since 2013. My research has been published in various respected journals, including Interdisciplinary Neurosurgery, Advanced Techniques and Case Management, Neuroscience, Frontiers in Integrative Neuroscience, Muscle and Nerve, and Neurology.

PhD: Statistics, Princeton University, Princeton, NJ, 1981.


Robustness; nonparametrics; statistical computing; simulations; reference intervals.

Research Areas



Results of a phase Ib study of SB-121, an investigational probiotic formulation, a randomized controlled trial in participants with autism spectrum disorder. Schmitt, LM; Smith, EG; Pedapati, EV; Horn, PS; Will, M; Lamy, M; Barber, L; Trebley, J; Meyer, K; Heiman, M; et al. Scientific Reports. 2023; 13.

From urges to tics in children with Tourette syndrome: associations with supplementary motor area GABA and right motor cortex physiology. Larsh, TR; Huddleston, DA; Horn, PS; Wu, SW; Cecil, KM; Jackson, HS; Edden, RA E; Mostofsky, SH; Gilbert, DL. Cerebral Cortex. 2023; 33:3922-3933.

Biomarkers of tic severity in children with Tourette syndrome: Motor cortex inhibition measured with transcranial magnetic stimulation. Batschelett, MA; Huddleston, DA; Crocetti, D; Horn, PS; Mostofsky, SH; Gilbert, DL. Developmental Medicine and Child Neurology. 2023.

Comparing electrical stimulation functional mapping with subdural electrodes and stereoelectroencephalography. Aungaroon, G; Vedala, K; Byars, AW; Ervin, B; Rozhkov, L; Horn, PS; Ihnen, SK Z; Holland, KD; Tenney, JR; Kremer, K; et al. Epilepsia. 2023.

A longitudinal study of creatine kinase and creatinine levels in Duchenne muscular dystrophy. Zygmunt, AM; Wong, BL; Horn, PS; Lambert, J; Bange, JE; Rybalsky, I; Chouteau, W; Tian, C. Muscle and Nerve. 2023; 67:138-145.

Stiripentol for Drug-Resistant Epilepsy Treatment in Tuberous Sclerosis Complex. Aungaroon, G; Mehta, A; Horn, PS; Franz, DN. Pediatric Neurology. 2023; 139:86-92.

Use of supported standing in males with Duchenne muscular dystrophy: Individual and family perspectives. Bonarrigo, K; McGuire, M; Dorich, JM; Bolger, A; Lambert, J; Horn, PS; Tian, C. Journal of Pediatric Rehabilitation Medicine. 2023.

Altered frontal connectivity as a mechanism for executive function deficits in fragile X syndrome. Schmitt, LM; Li, J; Liu, R; Horn, PS; Sweeney, JA; Erickson, CA; Pedapati, EV. Molecular Autism. 2022; 13.

Automated grading of enlarged perivascular spaces in clinical imaging data of an acute stroke cohort using an interpretable, 3D deep learning framework. Williamson, BJ; Khandwala, V; Wang, D; Maloney, T; Sucharew, H; Horn, P; Haverbusch, M; Alwell, K; Gangatirkar, S; Mahammedi, A; et al. Scientific Reports. 2022; 12.

Optimization, validation and initial clinical implications of a Luminex-based immunoassay for the quantification of Fragile X Protein from dried blood spots. Boggs, AE; Schmitt, LM; McLane, RD; Adayev, T; LaFauci, G; Horn, PS; Dominick, KC; Gross, C; Erickson, CA. Scientific Reports. 2022; 12.