Paul S. Horn, PhD

Biostatistician, Division of Neurology
Professor, UC Department of Pediatrics

paul.horn@cchmc.org

About

Biography

My area of research is statistical analysis and how to apply general statistical methodology to specific pediatric problems. I want to improve statistical analysis in pediatrics to provide more reliable evidence for decision making.

I am interested in providing answers to questions regarding the statistical methodology that applies to pediatric populations, such as appropriate reference ranges. One of my achievements is the development of quantile estimators that are relatively robust for smaller sample sizes.

I am a member of the International Committee for the Clinical and Laboratory Standards Institute. My career spans more 39 years, and I have worked at Cincinnati Children’s since 2013. My research has been published in various respected journals, including Interdisciplinary Neurosurgery, Advanced Techniques and Case Management, Neuroscience, Frontiers in Integrative Neuroscience, Muscle and Nerve, and Neurology.

Services and Specialties

Neurology

Interests

Robustness; nonparametrics; statistical computing; simulations; reference intervals.

Research Areas

Neurology

Publications

Health Related Quality of Life in Autistic Youth and Their Families. Nelson, MA; Shaffer, RC; Schmitt, LM; Coffman, MC; Horn, PS; Reisinger, DL; Erickson, CA. Journal of Autism and Developmental Disorders. 2025; 55:1982-1987.

Probing the Neurodynamic Mechanisms of Cognitive Flexibility in Depressed Individuals with Autism Spectrum Disorder. Elmaghraby, R; Blank, E; Miyakoshi, M; Gilbert, DL; Wu, SW; Larsh, T; Westerkamp, G; Liu, Y; Horn, PS; Erickson, CA; Pedapati, EV. Journal of Child and Adolescent Psychopharmacology. 2025; 35:231-243.

Results from a Double-Blind, Randomized, Placebo-Controlled, Single-Dose, Crossover Trial of Lovastatin or Minocycline in Fragile X Syndrome. McKinney, WS; Schmitt, LM; De Stefano, LA; Ethridge, L; Norris, JE; Horn, PS; Dauterman, S; Rosselot, H; Pedapati, EV; Reisinger, DL; Friedman, NR; Hong, M; Sweeney, JA; Erickson, C. Journal of Child and Adolescent Psychopharmacology. 2025; 35:211-221.

Delayed diagnosis in pediatric-onset aquaporin-4 positive neuromyelitis optica spectrum disorder with isolated area postrema syndrome. Mandle, Q; Nguyen, L; Horn, PS; Wheeler, YS; Wu, H; Poisson, KE. European Journal of Paediatric Neurology. 2025; 56:6-9.

Chronobiological Spatial Clusters of Cortical Regions in the Human Brain. Arya, R; Petito, GT; Housekeeper, J; Buroker, J; Scholle, C; Ervin, B; Frink, C; Horn, PS; Liu, W; Ruben, M; Smith, DF; Skoch, J; Mangano, FT; Greiner, HM; Holland, KD. Journal of Clinical Neurophysiology. 2025; 42:323-330.

User-defined virtual sensors: A new solution to the problem of temporal plus epilepsy sources. Tenney, J; Fujiwara, H; Skoch, J; Horn, P; Hong, S; Lee, O; Kremer, K; Arya, R; Holland, K; Mangano, F; Greiner, H. Epilepsia. 2025; 66:1071-1083.

Altered cortical excitability in tuberous sclerosis and the effect of mTOR inhibitors: An intracranial electrical stimulation study. Vedala, K; Aungaroon, G; Ritter, D; Greiner, HM; Tenney, JR; Skoch, J; Horn, PS; Leach, JL; Mangano, FT; Krueger, D; Arya, R. Clinical Neurophysiology. 2025; 172:1-9.

In children with attention‐deficit/hyperactivity disorder, less task‐related up‐modulation of motor cortex during response inhibition. Gilbert, DL; Crocetti, D; Horn, PS; Wu, SW; Huddleston, DA; Ehrman, JM; Migneault, KY; Mostofsky, SH. 2025; 3:26-36.

Accelerated Theta Burst Transcranial Magnetic Stimulation for Refractory Depression in Autism Spectrum Disorder. Blank, E; Gilbert, DL; Wu, SW; Larsh, T; Elmaghraby, R; Liu, R; Smith, E; Westerkamp, G; Liu, Y; Horn, PS; Greenstein, E; Sweeney, JA; Erickson, CA; Pedapati, EV. Journal of Autism and Developmental Disorders. 2025; 55:940-954.

Bone mineral density changes in patients on drug therapy for spinal muscular atrophy. Osman, A; Wasserman, H; Horn, PS; Broomall, E. Neuromuscular Disorders. 2025; 48:105300.