Paul S. Horn, PhD

Biostatistician, Division of Neurology
Professor, UC Department of Pediatrics

paul.horn@cchmc.org

About

Biography

My area of research is statistical analysis and how to apply general statistical methodology to specific pediatric problems. I want to improve statistical analysis in pediatrics to provide more reliable evidence for decision making.

I am interested in providing answers to questions regarding the statistical methodology that applies to pediatric populations, such as appropriate reference ranges. One of my achievements is the development of quantile estimators that are relatively robust for smaller sample sizes.

I am a member of the International Committee for the Clinical and Laboratory Standards Institute. My career spans more 39 years, and I have worked at Cincinnati Children’s since 2013. My research has been published in various respected journals, including Interdisciplinary Neurosurgery, Advanced Techniques and Case Management, Neuroscience, Frontiers in Integrative Neuroscience, Muscle and Nerve, and Neurology.

Interests

Robustness; nonparametrics; statistical computing; simulations; reference intervals.

Research Areas

Neurology

Publications

Appendicular lean mass index changes in patients with Duchenne muscular dystrophy and Becker muscular dystrophy. Wong, BL; Summer, S; Horn, PS; Rutter, MM; Rybalsky, I; Tian, C; Shellenbarger, KC; Kalkwarf, HJ. Journal of Cachexia, Sarcopenia and Muscle. 2023; 14:2804-2812.

Reliability of resting-state electrophysiology in fragile X syndrome. Liu, R; Pedapati, EV; Schmitt, LM; Shaffer, RC; Smith, EG; Dominick, KC; DeStefano, LA; Westerkamp, G; Horn, P; Sweeney, JA; et al. Biomarkers in Neuropsychiatry. 2023; 9:100070.

Results of a phase Ib study of SB-121, an investigational probiotic formulation, a randomized controlled trial in participants with autism spectrum disorder. Schmitt, LM; Smith, EG; Pedapati, EV; Horn, PS; Will, M; Lamy, M; Barber, L; Trebley, J; Meyer, K; Heiman, M; et al. Scientific Reports. 2023; 13:5192.

A sensitive and reproducible qRT-PCR assay detects physiological relevant trace levels of FMR1 mRNA in individuals with Fragile X syndrome. Straub, D; Schmitt, LM; Boggs, AE; Horn, PS; Dominick, KC; Gross, C; Erickson, CA. Scientific Reports. 2023; 13:3808.

MiR-324-5p inhibition after intrahippocampal kainic acid-induced status epilepticus does not prevent epileptogenesis in mice. McGann, AM; Westerkamp, GC; Chalasani, A; Danzer, CS K; Parkins, EV; Rajathi, V; Horn, PS; Pedapati, EV; Tiwari, D; Danzer, SC; et al. Frontiers in Neurology. 2023; 14:1280606.

P253 Motor function and genotype-phenotype correlations in paediatric Becker muscular dystrophy. Zygmunt, A; Shiuan, Y; Horn, P; Rybalsky, I; Reebals, L; Tian, C. Neuromuscular Disorders. 2023; 33:s146.

P258 Clinical profile of Duchenne muscular dystrophy associated with in-frame deletions in DMD. Zygmunt, A; Horn, P; Rybalsky, I; Reebals, L; Bange, J; Tian, C. Neuromuscular Disorders. 2023; 33:s147.

Biomarkers of tic severity in children with Tourette syndrome: Motor cortex inhibition measured with transcranial magnetic stimulation. Batschelett, MA; Huddleston, DA; Crocetti, D; Horn, PS; Mostofsky, SH; Gilbert, DL. Developmental Medicine and Child Neurology. 2023; 65:1321-1331.

Characterization of Migraine in Children and Adolescents With Generalized Joint Hypermobility: A Case-Control Study. Ghosh, A; Horn, PS; Kabbouche Samaha, M; Kacperski, J; LeCates, SL; White, S; Powers, SW; Hershey, AD. Neurology: Clinical Practice. 2023; 13:e200188.

Neuropsychological outcomes after epilepsy surgery: A comparison of stereo electroencephalography and subdural electrodes. Arya, R; Frink, C; Kargol, C; Byars, AW; Huddleston, D; Diedenhofer, DB; Aungaroon, G; Ervin, B; Horn, PS; Ihnen, SK Z; et al. European Journal of Neurology. 2023; 30:2986-2998.