Paul S. Horn, PhD

Biostatistician, Division of Neurology
Professor, UC Department of Pediatrics

paul.horn@cchmc.org

About

Biography

My area of research is statistical analysis and how to apply general statistical methodology to specific pediatric problems. I want to improve statistical analysis in pediatrics to provide more reliable evidence for decision making.

I am interested in providing answers to questions regarding the statistical methodology that applies to pediatric populations, such as appropriate reference ranges. One of my achievements is the development of quantile estimators that are relatively robust for smaller sample sizes.

I am a member of the International Committee for the Clinical and Laboratory Standards Institute. My career spans more 39 years, and I have worked at Cincinnati Children’s since 2013. My research has been published in various respected journals, including Interdisciplinary Neurosurgery, Advanced Techniques and Case Management, Neuroscience, Frontiers in Integrative Neuroscience, Muscle and Nerve, and Neurology.

Services and Specialties

Neurology

Interests

Robustness; nonparametrics; statistical computing; simulations; reference intervals.

Research Areas

Neurology

Publications

Understanding MEG Source Profiles in Tuberous Sclerosis. Greve, K; Ihnen, S; Arya, R; Fujiwara, H; Greiner, HM; Holland, KD; Horn, PS; Kremer, KM; Krueger, DA; Mangano, FT; Skoch, J; Tenney, JR. Journal of Clinical Neurophysiology. 2026.

Motor Physiology Transcranial Magnetic Stimulation–Based Biomarkers and Associated Neurocognitive Profiles in Attention‐Deficit/Hyperactivity Disorder. Deronda, AC; Sperry, A; Crocetti, D; Migneault, K; Horn, PS; Gilbert, DL; Rosch, KS; Mostofsky, SH. Annals of the Child Neurology Society. 2026.

From Infancy to Early School Age: Longitudinal Developmental Outcomes and Autism Diagnostic Stability in Tuberous Sclerosis Complex. Capal, JK; Ritter, DM; Horn, PS; Currans, K; Kent, B; Pearson, DA; Mansour, R; O'kelley, SE; Sahin, M; Bebin, EM; Rajaraman, R; Porter, BE; Northrup, H; Krueger, DA. Pediatric Neurology. 2026; 183:1-9.

2.36eP Assessing side effects of thrombocytopenia and hypertriglyceridemia for individuals with Duchenne muscular dystrophy treated with givinostat. Horn, P; Reebals, L; Zygmunt, A; Bramer, A; Mcanally, M; Wade, C; Tian, C. Neuromuscular Disorders. 2026; 67:106796.

2.64eP QTc prolongation in an individual with Duchenne muscular dystrophy treated with givinostat and lessons for clinicians. Tian, C; Zygmunt, A; Reebals, L; Wade, C; Horn, P; Mcanally, M; Mantell, B; Villa, C. Neuromuscular Disorders. 2026; 67:106823.

2.57P Real-world experience of safety and tolerability in 89 individuals with Duchenne muscular dystrophy initiating givinostat treatment; a retrospective review. Reebals, L; Bramer, A; Horn, P; Zygmunt, A; Mcanally, M; Tian, C. Neuromuscular Disorders. 2026; 67:106830.

2.13eP Tolerability of givinostat in combination with exon-skipping therapy in individuals with Duchenne muscular dystrophy. Wade, C; Bramer, A; Horn, P; Zygmunt, A; Reebals, L; Mcanally, M; Tian, C. Neuromuscular Disorders. 2026; 67:106737.

For Whom Does Eye Tracking Track: A Brief Report on Social Attention as a Precision Biomarker for Clinical Trials in Autism. Reisinger, DL; Shic, F; Horn, PS; Wink, L; Erickson, C. Biomarkers in Neuropsychiatry. 2026; 100143.

Programming parameters affecting seizure reduction in responsive neurostimulation patients at a pediatric center. Walker, T; Horn, PS; Byars, AW; Clark, DJ; Vedala, K; Mangano, FT; Skoch, J; Greiner, HM. Epilepsy Research. 2026; 228:107923.

Profile of Behavioral Comorbidities in Children With Fragile X Syndrome. Kaufmann, WE; Horn, PS. Journal of Autism and Developmental Disorders. 2026.