A photo of Rana Herro.

Rana Herro, PhD


  • Assistant Professor, UC Department of Pediatrics

About

Biography

Fibrosis is responsible for over 45% of deaths in the United States. Developing effective therapeutics and novel prognostic biomarkers for fibrotic diseases is the goal of my research at Cincinnati Children’s.

I’m particularly interested in tumor necrosis factor (TNF) superfamily members and their involvement in inflammation and fibrosis. More specifically, my lab investigates whether TNF molecules could be targets of therapeutic intervention to suppress disease symptoms and cure fibrosis associated with idiopathic pulmonary fibrosis, systemic sclerosis, non-alcoholic steatohepatitis, neutrophilic asthma and atopic dermatitis, among others.

Publications

Isolation of primary immune cells from fibrotic skin, esophageal, and gut tissue. Steele, H; Song, B; Willicut, A; Grimes, HL; Herro, R. Journal of Immunological Methods. 2021; 497.

Targeting TL1A/DR3 Signaling Offers a Therapeutic Advantage to Neutralizing IL13/IL4Rα in Muco-Secretory Fibrotic Disorders. Steele, H; Sachen, K; McKnight, AJ; Soloff, R; Herro, R. Frontiers in Immunology. 2021; 12.

Increased Production of LIGHT by T Cells in Eosinophilic Esophagitis Promotes Differentiation of Esophageal Fibroblasts Toward an Inflammatory Phenotype. Manresa, MC; Chiang, AW T; Kurten, RC; Dohil, R; Brickner, H; Dohil, L; Herro, R; Akuthota, P; Lewis, NE; Croft, M; et al. Gastroenterology. 2020; 159:1778-1792.e13.

TL1A Promotes Lung Tissue Fibrosis and Airway Remodeling. Herro, R; Miki, H; Sethi, GS; Mills, D; Mehta, AK; Nguyen, X; Feghali-Bostwick, C; Miller, M; Broide, DH; Soloff, R; et al. Journal of Immunology. 2020; 205:2414-2422.

Adenosine deaminase-1 delineates human follicular helper T cell function and is altered with HIV. Tardif, V; Muir, R; Cubas, R; Chakhtoura, M; Wilkinson, P; Metcalf, T; Herro, R; Haddad, EK. Nature Communications. 2019; 10.

The TWEAK/Fn14 pathway is required for calcineurin inhibitor toxicity of the kidneys. Claus, M; Herro, R; Wolf, D; Buscher, K; Rudloff, S; Huynh-Do, U; Burkly, L; Croft, M; Sidler, D. American Journal of Transplantation. 2018; 18:1636-1645.

LIGHT-HVEM signaling in keratinocytes controls development of dermatitis. Herro, R; Shui, J; Zahner, S; Sidler, D; Kawakami, Y; Kawakami, T; Tamada, K; Kronenberg, M; Croft, M. Journal of Experimental Medicine. 2018; 215:415-422.