Rana Herro, PhD

Assistant Professor, UC Department of Pediatrics

About

Biography

Fibrosis is responsible for over 45% of deaths in the United States. Developing effective therapeutics and novel prognostic biomarkers for fibrotic diseases is the goal of my research at Cincinnati Children’s.

I’m particularly interested in tumor necrosis factor (TNF) superfamily members and their involvement in inflammation and fibrosis. More specifically, my lab investigates whether TNF molecules could be targets of therapeutic intervention to suppress disease symptoms and cure fibrosis associated with idiopathic pulmonary fibrosis, systemic sclerosis, non-alcoholic steatohepatitis, neutrophilic asthma and atopic dermatitis, among others.

Services and Specialties

Pulmonology

Research Areas

Publications

The diverse roles of neutrophils from protection to pathogenesis. Herro, R; Grimes, HL. Nature Immunology. 2024; 25:2209-2219.

TNF superfamily control of tissue remodeling and fibrosis. Steele, H; Cheng, J; Willicut, A; Dell, G; Breckenridge, J; Culberson, E; Ghastine, A; Tardif, V; Herro, R. Frontiers in Immunology. 2023; 14:1219907.

1 Liver + 4 Diseases = n Drugs. Dell, GJ; Steele, H; Cheng, JL; Breckenridge, JE; Willicut, A; Ghastine, A; Culberson, E; Herro, R. Journal of immunology (Baltimore, Md. : 1950). 2023; 210:176.11.

Targeting Fibrosis to Improve Cancer Outcomes. Breckenridge, JE; Dell, G; Steele, H; Cheng, JL; Ghastine, A; Culberson, E; Herro, R. Journal of immunology (Baltimore, Md. : 1950). 2023; 210:245.04.

TL1A control of eczema and psoriasis. Cheng, JL; Steele, H; Breckenridge, J; Dell, G; Ghastine, A; Willicut, A; Herro, R. Journal of immunology (Baltimore, Md. : 1950). 2023; 210:151.01.

Shedding LIGHT and TL1A on Pulmonary Fibrosis. Steele, H; Cheng, JL; Willicut, A; Dell, G; Breckenridge, J; Ghastine, A; Herro, R. Journal of immunology (Baltimore, Md. : 1950). 2023; 210:176.07.

Live bacterial ligands universally regulate mTOR activity but are not essential for homeostatic innate immunity. Song, B; Zhang, X; Steele, H; Chou, C; Ferchen, K; Salomonis, N; Herro, R; Grimes, HL. Journal of immunology (Baltimore, Md. : 1950). 2023; 210:65.05.

Lymphotoxin beta receptor signaling directly controls airway smooth muscle deregulation and asthmatic lung dysfunction. Miki, H; Kiosses, WB; Manresa, MC; Gupta, RK; Sethi, GS; Herro, R; Da Silva Antunes, R; Dutta, P; Miller, M; Fung, K; Ay, F; Broide, DH; Tumanov, AV; Croft, M. Journal of Allergy and Clinical Immunology. 2023; 151:976-990.e5.

A Deficiency in the Cytokine TNFSF14/LIGHT Limits Inflammation and Remodeling in Murine Eosinophilic Esophagitis. Manresa, MC; Miki, H; Miller, J; Okamoto, K; Dobaczewska, K; Herro, R; Gupta, RK; Kurten, R; Aceves, SS; Croft, M. Journal of immunology (Baltimore, Md. : 1950). 2022; 209:ji2200326.

3194 – LIVE BACTERIAL LIGANDS PROGRAM CORE HEMATOPOIETIC GENE EXPRESSION. Song, B; Ferchen, K; Chou, C; Zhang, X; Steele, H; Herro, R; Salomonis, N; Grimes, HL. Experimental Hematology. 2022; 111:s142.