About
Biography
Fibrosis is responsible for over 45% of deaths in the United States. Developing effective therapeutics and novel prognostic biomarkers for fibrotic diseases is the goal of my research at Cincinnati Children’s.
I’m particularly interested in tumor necrosis factor (TNF) superfamily members and their involvement in inflammation and fibrosis. More specifically, my lab investigates whether TNF molecules could be targets of therapeutic intervention to suppress disease symptoms and cure fibrosis associated with idiopathic pulmonary fibrosis, systemic sclerosis, non-alcoholic steatohepatitis, neutrophilic asthma and atopic dermatitis, among others.
PhD: University of Paris, Orsay-Paris XI, France.
Postdoc: The Scripps Research Institute, La Jolla, CA.
Instructor: La Jolla Institute for Allergy and Immunology, La Jolla, CA.
Research Areas
Allergy and Immunology, Pulmonary Medicine, Immunobiology
Publications
A Deficiency in the Cytokine TNFSF14/LIGHT Limits Inflammation and Remodeling in Murine Eosinophilic Esophagitis. Journal of Immunology. 2022.
Lymphotoxin beta receptor signaling directly controls airway smooth muscle deregulation and asthmatic lung dysfunction. Journal of Allergy and Clinical Immunology. 2022.
A Deficiency in the Cytokine TNFSF14/LIGHT Limits Inflammation and Remodeling in Murine Eosinophilic Esophagitis. Journal of Immunology. 2022.
3194 – LIVE BACTERIAL LIGANDS PROGRAM CORE HEMATOPOIETIC GENE EXPRESSION. Experimental Hematology. 2022; 111.
Isolation of primary immune cells from fibrotic skin, esophageal, and gut tissue. Journal of Immunological Methods. 2021; 497.
Targeting TL1A/DR3 Signaling Offers a Therapeutic Advantage to Neutralizing IL13/IL4Rα in Muco-Secretory Fibrotic Disorders. Frontiers in Immunology. 2021; 12.
Increased Production of LIGHT by T Cells in Eosinophilic Esophagitis Promotes Differentiation of Esophageal Fibroblasts Toward an Inflammatory Phenotype. Gastroenterology. 2020; 159:1778-1792.e13.
TL1A Promotes Lung Tissue Fibrosis and Airway Remodeling. Journal of Immunology. 2020; 205:2414-2422.
TNFSF14 (LIGHT) Induces Airway Smooth Muscle Contraction. Journal of Immunology. 2020; 204:65.6-65.6.
Shedding LIGHT and TL1A on fibrosis. Journal of Immunology. 2020; 204:234.5-234.5.
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