A photo of Rashmi Hegde.

Professor, UC Department of Pediatrics

513-636-5947

513-636-6772

Biography & Affiliation

Biography

Rashmi Hegde received her PhD in medicinal chemistry from the University of Pittsburgh in 1989. She received post-doctoral training in the Department of Molecular Biophysics and Biochemistry at Yale University, where she was a fellow of the National Cancer Center. She was appointed assistant professor of biochemistry at New York University School of Medicine and the Skirball Institute of Biomolecular Medicine in 1994. She is presently a full professor in the Division of Developmental Biology at Children's Hospital Research Foundation within the Department of Pediatrics at the University of Cincinnati College of Medicine.

Clinical Interests

Pre-clinical validation of anti-angiogenic agents for use in the treatment of retinopathies, cancer and pulmonary disease.

Research Interests

Molecular mechanisms involved in normal development and in disease states using in vitro (cellular and solution biochemistry and structural biology) and in vivo (mouse models) strategies; developing novel therapeutic strategies via structure-aided drug design coupled with in vitro validation and in vivo pre-clinical studies.

Academic Affiliation

Professor, UC Department of Pediatrics

Department

Developmental Biology

Science Blog

Education

PhD: University of Pittsburgh, Pittsburgh, PA, 1989.

Post-doctoral Fellowship: Yale University, 1989-1994.

Assistant Professor: New York University School of Medicine, Skirball Institute, 1994-2000.

Associate Professor: Cincinnati Children's Hospital Medical Center, 2001-2007.

Professor: Cincinnati Children's Hospital Medical Center, 2008-present.

Publications

Selected Publication

The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth. Wang, Y; Pandey, RN; Riffle, S; Chintala, H; Wikenheiser-Brokamp, KA; Hegde, RS. Molecular Cancer Therapeutics. 2018; 17:1659-1669.

The Eyes Absent Proteins in Developmental and Pathological Angiogenesis. Wang, Y; Tadjuidje, E; Pandey, RN; III, SJ A; Smith, LE H; Lang, RA; Hegde, RS. The American journal of pathology. 2016; 186:568-578.

The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension. Wang, Y; Pandey, RN; York, AJ; Mallela, J; Nichols, WC; Hu, Y; Molkentin, JD; Wikenheiser-Brokamp, KA; Hegde, RS. Nature Communications. 2019; 10.

An opsin 5-dopamine pathway mediates light-dependent vascular development in the eye. Nguyen, MT; Vemaraju, S; Nayak, G; Odaka, Y; Buhr, ED; Alonzo, N; Tran, U; Batie, M; Upton, BA; Darvas, M; et al. Nature Cell Biology. 2019; 21:420-429.

Linking hypoxia, DNA damage and proliferation in multicellular tumor spheroids. Riffle, S; Pandey, RN; Albert, M; Hegde, RS. BMC Cancer. 2017; 17.

Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids. Riffle, S; Hegde, RS. Journal of Experimental and Clinical Cancer Research. 2017; 36.

ETS transcription factors Etv2 and Fli1b are required for tumor angiogenesis. Baltrunaite, K; Craig, MP; Desai, SP; Chaturvedi, P; Pandey, RN; Hegde, RS; Sumanas, S. Angiogenesis. 2017; 20:307-323.

Novel and recurrent CIB2 variants, associated with nonsyndromic deafness, do not affect calcium buffering and localization in hair cells. Seco, CZ; Giese, AP; Shafique, S; Schraders, M; Oonk, AM M; Grossheim, M; Oostrik, J; Strom, T; Hegde, R; van Wijk, E; et al. European Journal of Human Genetics. 2016; 24:542-549.

A Novel C-Terminal CIB2 (Calcium and Integrin Binding Protein 2) Mutation Associated with Non-Syndromic Hearing Loss in a Hispanic Family. Patel, K; Giese, AP; Grossheim, JM; Hegde, RS; Delio, M; Samanich, J; Riazuddin, S; Frolenkov, GI; Cai, J; Ahmed, ZM; et al. PLoS ONE. 2015; 10:e0133082-e0133082.

BAZ1B is dispensable for H2AX phosphorylation on Tyrosine 142 during spermatogenesis. Broering, TJ; Wang, Y; Pandey, RN; Hegde, RS; Wang, S; Namekawa, SH. Biology Open. 2015; 4:873-884.