Scott K. Holland, PhD

Director, Research in Patient Services

Director, Reading and Literacy Discovery Center

Academic Affiliations

Professor, UC Department of Pediatrics

UC Department of Radiology

Phone 513-636-7565

Fax 513-636-0434


Advanced neuroimaging applications of MRI in pediatrics; functional MRI of language, hearing and neuroplasticity following brain injury; brain development. 

Scott Holland is a physicist by training with a BS (1980) in physics from Muhlenberg College, Allentown, PA, and an MS (1982) and PhD (1985) in engineering and applied science from Yale University.

After a year (1985-86) as a research engineer with the Electromagnetic Sciences Laboratory at Stanford Research Institute (SRI International), Menlo Park, CA, Scott returned to the Yale School of Medicine as a post-doctoral fellow (1986-88) and later as an assistant professor (1988-94) of diagnostic radiology.

He joined the faculty of the University of Cincinnati College of Medicine in 1994 as associate professor of radiology and pediatrics and served as scientific director of the Imaging Research Center at Children's Hospital Medical Center until 2003.

In 2005 he founded the Pediatric Neuroimaging Research Consortium with the Department of Pediatric Radiology and the Divisions of Neurosurgery, Neurology, Psychiatry and Biostatistics at Cincinnati Children's. The PNRC continues to grow and currently consists of eight full-time faculty members engaged in research using a broad range of neuroimaging techniques to study the developing brain under the influence of diseases of childhood. From 2009 to 2013, Scott led the Communication Sciences Research Center as its founding director. Currently he is serving as director of the new Division of Research in Patient Services.

His research currently focuses on pediatric neuroimaging applications of MRI, MEG and EEG methods; including perfusion MRI, functional MRI, and image processing methods, to study development of the neural circuitry of hearing, language, speech and reading capabilities through childhood. His discoveries regarding changes in brain activity and connectivity during typical childhood development and under the influence of neurological disorders have been influential in our understanding of neuroplasticity and reorganization of the developing brain in response to injury.

BS: Physics (magna cum laude), Muhlenberg College, 1980.

MS: Engineering & Applied Science, Yale University,1982.

MPhil: Engineering & Applied Science, Yale University, 1983.

PhD: Engineering and Applied Science, Yale University, 1985.

View PubMed Publications

Res Hafeman DM, Bebko G, Bertocci MA, Fournier JC, Bonar L, Holland SK, Phillips ML. Abnormal Deactivation of the Inferior Frontal Gyrus During Implicit Emotion Processing in Youth with Bipolar Disorder: Attenuated by Medication. J Psychiatr Res. 2014;58:129-136.

Horowitz-Kraus T, Cicchino N, Amiel M, Holland SK, Breznitz Z. Reading Improvement in English- and Hebrew-Speaking Children with Reading Difficulties after Reading Acceleration Training. Ann Dyslexia. 2014;64(3):183-201.

Jacola LM, Byars AW, Hickey F, Vannest J, Holland SK, Schapiro MB. Functional Magnetic Resonance Imaging of Story Listening in Adolescents and Young Adults with Down Syndrome: Evidence for Atypical Neurodevelopment. J Intellect Disabil. 2014;58(10):892-902.

Bertocci MA, Bebko G, Olino T, Fournier J, Hinze AK, Bonar L, Phillips ML. Behavioral and Emotional Dysregulation Trajectories Marked by Prefrontal-Amygdala Function in Symptomatic Youth. Psychol Med. 2014;44(12),:2603-2615.

Horowitz-Kraus T, Wang Y, Plante E, Holland SK. Involvement of the Right Hemisphere in Reading Comprehension: A Dti Study. Brain Res. 2014;1582:34-44.

Schmithorst VJ, Vannest J, Lee G, Hernandez-Garcia L, Plante E, Rajagopal A, The CMIND Authorship Consortium. Evidence That Neurovascular Coupling Underlying the Bold Effect Increases with Age During Childhood. Hum Brain Mapp. 2014.

Vannest J, Rajagopal A, Cicchino ND, Franks-Henry J, Simpson SM, Lee G, The CMIND Authorship Consortium. Factors Determining Success of Awake and Asleep Magnetic Resonance Imaging Scans in Nonsedated Children. Neuropediatrics. 2014.

*Farah R, Schmithorst VJ, Keith RW, Holland SK. Altered White Matter Microstructure Underlies Listening Difficulties in Children Suspected of Auditory Processing Disorders: A Dti Study. Brain and Behavior. 2014;4(4):531-543.

Rajagopal A, Byars A, Schapiro M, Lee GR, Holland SK. Success Rates for Functional MR Imaging in Children. AJNR Am J Neuroradiol. 2014.

Wilke M, Rose DF, Holland SK, Leach JL. Multidimensional Morphometric 3d MRI Analyses for Detecting Brain Abnormalities in Children: Impact of Control Population. Hum Brain Mapp. 2014;35(7):3199-3215.

Reading & Literacy Discovery Center Tier 3. Principal Investigator. Schroth Charitable Trust. Jan 2014-Dec 2016.

Structural and Network-Function Correlates of Fragmented Early Life Across Species. Consultant. National Institutes of Health. June 2013-April 2018. 1P50MH096889-01.

Imaging the Effect of Centrotemporal Spikes and Seizures on Language in Children. Collaborator. National Institutes of Health. July 2011-June 2016. R01 NS065840-01A1.