A photo of Taosheng Huang.

Professor, UC Department of Pediatrics


Board Certified

My Biography & Research


Taosheng Huang, MD, PhD, is a physician-scientist with substantial experience in translation research, particularly in mitochondrial medicine. After obtaining his MD, PhD, Dr. Huang did his pediatrics residency at Georgetown University Hospital 1993 to 1996. He completed his clinical genetics and clinical molecular genetics fellowship at Harvard Medical School and became a junior faculty member at the Children’s Hospital at Harvard from 1999. Dr. Huang is board-certified in pediatrics, clinical genetics and clinical molecular genetics. Dr. Huang moved to UC Irvine in 2001 and became a independent investigator.

The primary interest of his lab is in translation research, such as the genetic basis of optic atrophy and other mitochondrial diseases. Dr. Huang has published over 50 articles on a variety of topics that range from genetic syndromes to molecular mechanisms with experience and spectrum of interests. Recently, he has been working on mitochondria-related optic atrophy and the molecular basis of other mitochondria disease. He served as the director for the MitoMed Molecular Diagnostics Lab at UC Irvine for 8 years. The laboratory is CLIA-certified and mainly engaged in the study of molecular basis of mitochondria disease. The mutation of mitochondrial genome causes many human conditions, including cancer, diabetes and degenerative neurological disorders. Recently, Dr. Huang moved to Cincinnati Children's Hospital Medical Center to direct the program of mitochondrial medicine. The goal of the program is to integrate the research, molecular testing and clinical service to improve the care of patients with mitochondrial disease.

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Academic Affiliation

Professor, UC Department of Pediatrics


Genetics, Mitochondrial Disorders, Human Genetics

Science Blog

My Locations

My Education

PhD: Biomedical Science, Mount Sinai Medical School, New York, 1991.

MS: Biochemistry, The Third Military Medical College, Chongqing, China, 1986.

MD: (Passed US Medical Board Exam step I, Step II and Step III), Fujian Medical College, Fuzhou, Fujian, China, 1983.

Research Fellowship: Seidman Laboratory, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, Dec 1997-Jul 1999.

Clinical Fellowship: Clinical Genetics and Clinical Molecular Genetics, Children’s Hospital, Harvard Medical School, Boston, Massachusetts, Jul 1996-Jul 1999.

Residency: Pediatrics, Georgetown University Medical School, Children’s Medical Center, Washington, DC, Jul 1993-Jul 1996.

Postdoctoral Fellowship: Jerome H. Holland Laboratory, American Red Cross, Rockville, Maryland, Dec 1991-Jul 1993.

My Publications

Systemic administration of AAV-Slc25a46 mitigates mitochondrial neuropathy in Slc25a46-/- mice. Yang, L; Slone, J; Li, Z; Lou, X; Hu, Y; Queme, LF; Jankowski, MP; Huang, T. Human Molecular Genetics. 2020; 29:649-661.

Principles guiding the development of clinical practice guidelines for medical genetics and genomics specialty. Huang, T; Li, P. Zhonghua Yi Xue Yi Chuan Xue Za Zhi ==. 2020; 37:219-225.

Is quasi-Mendelian mtDNA competition enough to drive transmission of paternal mtDNA?. Slone, J; Luo, S; Atwal, PS; Huang, T. Proceedings of the National Academy of Sciences of USA. 2019; 116:14799-148000.

Mitochondrial DNA Variants and Common Diseases: A Mathematical Model for the Diversity of Age-Related mtDNA Mutations. Li, H; Slone, J; Fei, L; Huang, T. Cells. 2019; 8:608-608.

Contribution of mitochondrial ND1 3394T > C mutation to the phenotypic manifestation of Leber's hereditary optic neuropathy. Ji, Y; Zhang, J; Yu, J; Wang, Y; Lu, Y; Liang, M; Li, Q; Jin, X; Wei, Y; Meng, F; et al. Human Molecular Genetics. 2019; 28:1515-1529.

A rapid bioanalytical tool for detection of sequence-specific circular DNA and mitochondrial DNA point mutations. Zhang, Y; Kaynak, A; Huang, T; Esfandiari, L. Analytical and Bioanalytical Chemistry. 2019; 411:1935-1941.

Reply to Lutz-Bonengel et al.: Biparental mtDNA transmission is unlikely to be the result of nuclear mitochondrial DNA segments. Luo, S; Alexander Valencia, C; Zhang, J; Lee, NC; Slone, J; Gui, B; Wang, X; Li, Z; Dell, S; Brown, J; et al. Proceedings of the National Academy of Sciences of USA. 2019; 116:1823-1824.

Foreign experience the history and current status of medical genetics and genomics system in the United States. Yonghui, J; Taoshertg, H. Zhonghua Yi Xue Yi Chuan Xue Za Zhi ==. 2019; 36:1-6.

Biparental inheritance of mitochondrial DNA in humans. Luo, S; Valencia, CA; Zhang, J; Lee, NC; Slone, J; Gui, B; Wang, X; Li, Z; Dell, S; Brown, J; et al. Proceedings of the National Academy of Sciences of USA. 2018; 115:13039-13044.

Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology. Zhang, C; Seo, J; Murakami, K; Salem, ES B; Bernhard, E; Borra, VJ; Choi, K; Yuan, CL; Chan, CC; Chen, X; et al. Nature Communications. 2018; 9.