A photo of Taosheng Huang.

Professor, UC Department of Pediatrics

513-803-9260

Board Certified

My Biography & Research

Biography

Taosheng Huang, MD, PhD, is a physician-scientist with substantial experience in translation research, particularly in mitochondrial medicine. After obtaining his MD, PhD, Dr. Huang did his pediatrics residency at Georgetown University Hospital 1993 to 1996. He completed his clinical genetics and clinical molecular genetics fellowship at Harvard Medical School and became a junior faculty member at the Children’s Hospital at Harvard from 1999. Dr. Huang is board-certified in pediatrics, clinical genetics and clinical molecular genetics. Dr. Huang moved to UC Irvine in 2001 and became a independent investigator.

The primary interest of his lab is in translation research, such as the genetic basis of optic atrophy and other mitochondrial diseases. Dr. Huang has published over 50 articles on a variety of topics that range from genetic syndromes to molecular mechanisms with experience and spectrum of interests. Recently, he has been working on mitochondria-related optic atrophy and the molecular basis of other mitochondria disease. He served as the director for the MitoMed Molecular Diagnostics Lab at UC Irvine for 8 years. The laboratory is CLIA-certified and mainly engaged in the study of molecular basis of mitochondria disease. The mutation of mitochondrial genome causes many human conditions, including cancer, diabetes and degenerative neurological disorders. Recently, Dr. Huang moved to Cincinnati Children's Hospital Medical Center to direct the program of mitochondrial medicine. The goal of the program is to integrate the research, molecular testing and clinical service to improve the care of patients with mitochondrial disease.

Additional Languages

Mandarin

Academic Affiliation

Professor, UC Department of Pediatrics

Departments

Human Genetics, Human Genetics, Mayerson Center for Safe and Healthy Children, Cardiovascular Diseases Genetic Testing Program

My Locations

My Education

PhD: Biomedical Science, Mount Sinai Medical School, New York, 1991.

MS: Biochemistry, The Third Military Medical College, Chongqing, China, 1986.

MD: (Passed US Medical Board Exam step I, Step II and Step III), Fujian Medical College, Fuzhou, Fujian, China, 1983.

Research Fellowship: Seidman Laboratory, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, Dec 1997-Jul 1999.

Clinical Fellowship: Clinical Genetics and Clinical Molecular Genetics, Children’s Hospital, Harvard Medical School, Boston, Massachusetts, Jul 1996-Jul 1999.

Residency: Pediatrics, Georgetown University Medical School, Children’s Medical Center, Washington, DC, Jul 1993-Jul 1996.

Postdoctoral Fellowship: Jerome H. Holland Laboratory, American Red Cross, Rockville, Maryland, Dec 1991-Jul 1993.

My Publications

Sherrill JD, Kc K, Wang X, Wen T, Chamberlin A, Stucke EM, Collins MH, Abonia JP, Peng Y, Wu Q, Putnam PE, Dexheimer PJ, Aronow BJ, Kottyan LC, Kaufman KM, Harley JB, Huang T†, Rothenberg ME†. †Contribute Equally. Whole exome sequencing identifies a genetic link between mitochondrial dysfunction and eosinophilic gastrointestinal disease. JCI Insight. 2019.

Zhang Y, Kaynak A, Huang T, Esfandiari L. A rapid bioanalytical tool for detection of sequence-specific Circular DNA and Mitochondrial DNA point mutations. Analytical and Bioanalytical Chemistry. 2019.

Tan ZY, Huang T, Ngeow J. Gene editing applications in inherited cancer: How can we achieve this in the clinic? 2019.

Zhuo Li, Slone J, Wu L, Huang T. (2018). Neurodegenerative Diseases Associated with Mutations in SLC25A46. In Neurodegeneration. London, United Kingdom: IntechOpen.

Ji Y, Zhang J, Yu J, Wang Y, Lu Y, Liang M, Li Q, Jin X, Wei Y, Meng F, Gao Y, Cang X, Tong Y, Liu X, Zhang M, Jiang P, Zhu T, Mo JQ, Huang T, Jiang P, Guan MX. Contribution of mitochondrial ND1 3394T>C mutation to the phenotypic manifestation of Leber’s hereditary optic neuropathy. Hum Mol Genet. 2018 Dec 31.

Luo S, Valencia CA, Zhang J, Lee NC, Slone J, Gui B, Wang X, Li Z, Dell S, Brown J, Chen SM, Chien YH, Hwu WL, Fan PC, Wong LJ, Atwal PS, Huang T. Biparental Inheritance of Mitochondrial DNA in Humans. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):13039-13044.

Slone J, Peng Y, Chamberlin A, Harris B, Kaylor J, McDonald MT, Lemmon M, El-Dairi MA, Tchapyjnikov D, Gonzalez-Krellwitz LA, Sellars EA, McConkie-Rosell A, Reinholdt LG, Huang T. Biallelic mutations in FDXR cause neurodegeneration. J Hum Genet. 2018 Dec;63(12):1211-1222.

Hayashi Y, Zhang Y, Yokota A, Yan X, Liu J, Choi K, Li B, Sashida G, Peng Y, Xu Z, Huang R, Zhang L, Freudiger GM, Wang J, Dong Y, Zhou Y, Wang J, Wu L, Bu J, Chen A, Zhao X, Sun X, Chetal K, Olsson A, Watanabe M, Romick-Rosendale LE, Harada H, Shih LY, Tse W, Bridges JP, Caligiuri MA, Huang T, Zheng Y, Witte DP, Wang QF, Qu CK, Salomonis N, Grimes HL, Nimer SD, Xiao Z, Huang G. Pathobiologic Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes. Cancer Discov. 2018 Nov;8(11):1438-1457.

Zhang C, Seo J, Murakami K, Salem ESB, Bernhard E, Borra VJ, Choi K, Yuan CL, Chan CC, Chen X, Huang T, Weirauch MT, Divanovic S, Qi NR, Thomas HE, Mercer CA, Siomi H, Nakamura T. Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology. Nat Commun. 2018 Sep 10;9(1):3658.

Brockhage R, Slone J, Ma Z, Hegde MR, Valencia CA, Huang T. Validation of the diagnostic potential of mtDNA copy number derived from whole genome sequencing. J Genet Genomics. 2018 Jun 6.