High Res

Rulang Jiang, PhD

Member, Division of Developmental Biology

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-3212

Email rulang.jiang@cchmc.org

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Research Interests

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Genetic basis and developmental mechanisms of congenital craniofacial malformations; tendon development, homeostasis, and heterotopic ossification

Biography

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Rulang Jiang, PhD, is professor of Pediatrics at Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine. Prior to joining Cincinnati Children's in 2011, he was a tenured professor of Biomedical Genetics at University of Rochester School of Medicine and Dentistry where he established and led a continuously NIH-funded program in the areas of craniofacial development and birth defect research from 1999 to 2011. At Cincinnati Children's, he has expanded research program into understanding of musculoskeletal diseases and tissue repair/regeneration. In addition to NIH grant support, his research is supported by the Shriners Hospital for Children.

Education and Training

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BS: Nanjing Normal University, Nanjing, China, 1984.

MS: Genetics, Chinese Academy of Sciences, Beijing, China, 1987.

PhD: Wesleyan University, Middletown, CT, 1995.

Publications

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View PubMed Publications

Li C, Lan Y, Krumlauf R, Jiang R. Modulating Wnt signaling rescues palate morphogenesis in Pax9 mutant mice. Journal of Dental Research. 2017;96(11):1273-1281.

Li C, Lan Y, Jiang R. Molecular and Cellular Mechanisms of Palate Development. Journal of Dental Research. 2017;96(11):1184-1191.

Kwon H-JE, Jia S, Lan Y, Liu H, Jiang R. Activin and BMP4 signaling converge on Wnt activation during odontogenesis. Journal of Dental Research. 2017;96(10):1145-1152.

Han L, Xu J, Grigg E, Slack M, Chaturvedi P, Jiang R, Zorn AM. Osr1 functions downstream of Hedgehog pathway to regulate foregut development. Developmental Biology. 2017;427(1):72-83.

Fu X, Xu J, Chaturvedi P, Liu H, Jiang R, Lan Y. Identification of Osr2 Transcriptional target genes in palate development. Journal of Dental Research. 2017;96(12):1451-1458.

Xu J, Liu H, Lan Y, Aronow BJ, Kalinichenko VV, Jiang R. A Shh-Foxf-Fgf18-Shh molecular circuit regulating palate development. PLOS Genetics. 2016;12(1):e1005769.

Lan Y, Zhang N, Liu H, Xu J, Jiang R. Golgb1 regulates protein glycosylation and is crucial for mammalian palate development. Development. 2016;143:2344-2355.

Xu J, Liu H, Chai OH, Lan Y, Jiang R. Osr1 interacts synergistically with Wt1 to regulate kidney organogenesis. PLOS One. 2016;11(7):e0159597.

Jia S, Kwon H-JE, Lan Y, Zhou J, Liu H, Jiang R. Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists. Developmental Biology. 2016;420(1):110-119.

Liu H, Xu J, Liu C-F, Lan Y, Wylie C, Jiang R. Whole transcriptome expression profiling of mouse limb tendon development by using RNA-seq. Journal of Orthopaedic Research. 2015;33:840-848.

Grants

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Mandible Development. Principal Investigator. National Institutes of Health. Jul 2017-Jun 2022.

Molecular Patterning of Mammalian Dentition. Principal Investigator. National Institutes of Health. Jul 2009-Jun 2018.

Molecular Regulation of Palate Development. Principal Investigator. Shriners Hospital for Children Research Grant. Jan 2017-Dec 2021.