A photo of Jennifer Kaplan.

Associate Professor, UC Department of Pediatrics

513-636-4259

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My Biography & Research

Biography

Dr. Kaplan's long-term career goal is to improve the outcomes of critically ill children. She began her research career in fellowship studying sepsis, driven by the realization that there are few clinical therapies that improve outcomes in critically ill children with severe infections. She focused on the nuclear receptor PPARg as a potential target to alter the sepsis-induced inflammatory state. PPARg is a nuclear receptor with effects on lipid and glucose metabolism, atherosclerosis and inflammation. She elected to extend her fellowship a fourth year to complete training in molecular epidemiology and the Master of Science program at the University of Cincinnati Academic Health Center. She received grant funding from the Translational Research Initiative and the NIH K12 Child Health Research Career Development Award at Cincinnati Children's to investigate the alteration of PPARg in peripheral blood cells from children with sepsis. she is a recipient of an NIH Mentored Clinical Scientist Research Career Development Award (K08).

Clinical Interests

  • Sepsis
  • Respiratory failure

Academic Affiliation

Associate Professor, UC Department of Pediatrics

Departments

Pediatric Intensive Care Unit PICU, Critical Care

My Education

MS: Epidemiology, University of Cincinnati College of Medicine, Cincinnati, OH.

MD: University of Cincinnati, Cincinnati, OH, 1999.

BA: Washington University in St. Louis, St. Louis, Missouri.

Fellowship: Pediatric Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Residency: Pediatrics, Orlando Regional Healthcare, Orlando, FL.

Certification: Pediatric Critical Care Medicine, Pediatrics.

My Publications

Selected Publication

Route of Oseltamivir Administration Affects Metabolite Concentrations in Critically Ill Children. Tang Girdwood, SC; Mizuno, T; Krallman, KA; Benken, LA; Stoneman, EM; Yunger, TM; Wong, HR; Vinks, AA; Kaplan, JM. The Pediatric Infectious Disease Journal. 2019; 38:1224-1227.

SEPSIS INDUCES ADIPOSE TISSUE BROWNING IN NONOBESE MICE BUT NOT IN OBESE MICE. Ayalon, I; Shen, H; Williamson, L; Stringer, K; Zingarelli, B; Kaplan, JM. Shock. 2018; 50:557-564.

Phase 1 safety and pharmacokinetic study on the use of pioglitazone in critically ill patients with sepsis: a randomized clinical trial. Kaplan, JM; Zingarelli, B; Krallman, K; Girdwood, ST; Lagory, D; Mizuno, T; Fei, L; Wong, HR; Vinks, AA. Intensive Care Medicine. 2018; 44:2006-2008.

High fat diet-induced obesity increases myocardial injury and alters cardiac STAT3 signaling in mice after polymicrobial sepsis. DeMartini, T; Nowell, M; James, J; Williarnson, L; Lahni, P; Shen, H; Kaplan, JM. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 2017; 1863:2654-2660.

Obesity Enhances Sepsis-Induced Liver Inflammation and Injury in Mice. Kaplan, JM; Nowell, M; Lahni, P; Shen, H; Shanmukhappa, SK; Zingarelli, B. Obesity. 2016; 24:1480-1488.

Higher-volume hypertonic saline and increased thrombotic risk in pediatric traumatic brain injury. Webster, DL; Fei, L; Falcone, RA; Kaplan, J. Journal of Critical Care. 2015; 30:1267-1271.

Pioglitazone reduces inflammation through inhibition of NF-kappa B in polymicrobial sepsis. Kaplan, J; Nowell, M; Chima, R; Zingarelli, B. Innate Immunity. 2014; 20:519-528.

Short-Term High Fat Feeding Increases Organ Injury and Mortality After Polymicrobial Sepsis. Kaplan, JM; Nowell, M; Lahni, P; O'Connor, MP; Hake, PW; Zingarelli, B. Obesity. 2012; 20:1995-2002.

Biomarker discovery and development in pediatric critical care medicine. Kaplan, JM; Wong, HR. Pediatric Critical Care Medicine. 2011; 12:165-173.

Changes in peroxisome proliferator-activated receptor-gamma activity in children with septic shock. Kaplan, JM; Denenberg, A; Monaco, M; Nowell, M; Wong, H; Zingarelli, B. Intensive Care Medicine. 2010; 36:123-130.