Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism.
Kuang, Y; Golan, O; Preusse, K; Cain, B; Christensen, CJ; Salomone, J; Campbell, I; Okwubido-Williams, FV; Hass, MR; Yuan, Z; et al.
eLife.
2020;
9.
Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors.
Seymour, PA; Collin, CA; Egeskov-Madsen, AL R; Jorgensen, MC; Shimojo, H; Imayoshi, I; de Lichtenberg, KH; Kopan, R; Kageyama, R; Serup, P.
Developmental Cell.
2020;
52:731-747.e8.
Hamartin regulates cessation of mouse nephrogenesis independently of Mtor.
Volovelsky, O; Nguyen, T; Jarmas, AE; Combes, AN; Wilson, SB; Little, MH; Witte, DP; Brunskill, EW; Kopan, R.
Proceedings of the National Academy of Sciences of USA.
2018;
115:5998-6003.
Glomerular endothelial cell maturation depends on ADAM10, a key regulator of Notch signaling.
Farber, G; Hurtado, R; Loh, S; Monette, S; Mtui, J; Kopan, R; Quaggin, S; Meyer-Schwesinger, C; Herzlinger, D; Scott, RP; et al.
Angiogenesis.
2018;
21:335-347.
Haploinsufficiency for the Six2 gene increases nephron progenitor proliferation promoting branching and nephron number.
Combes, AN; Wilson, S; Phipson, B; Binnie, BB; Ju, A; Lawlor, KT; Cebrian, C; Walton, SL; Smyth, IM; Moritz, KM; et al.
Kidney International.
2018;
93:589-598.
Analysis of chromatin accessibility in human epidermis identifies putative barrier dysfunction-sensing enhancers.
Lander, JM; Supp, DM; He, H; Martin, LJ; Chen, X; Weirauch, MT; Boyce, ST; Kopan, R.
PLoS ONE.
2017;
12:e0184500-e0184500.
The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force.
Kovall, RA; Gebelein, B; Sprinzak, D; Kopan, R.
Developmental Cell.
2017;
41:228-241.
Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy.
Cunningham, TJ; Tabacchi, M; Eliane, J; Tuchayi, SM; Manivasagam, S; Mirzaalian, H; Turkoz, A; Kopan, R; Schaffer, A; Saavedra, AP; et al.
Journal of Clinical Investigation.
2017;
127:106-116.
Making new kidneys: On the road from science fiction to science fact.
Volovelsky, O; Kopan, R.
Current Opinion in Organ Transplantation.
2016;
21:574-580.
The Notch Intracellular Domain Has an RBPj-Independent Role during Mouse Hair Follicular Development.
Turkoz, M; Townsend, RR; Kopan, R.
Journal of Investigative Dermatology.
2016;
136:1106-1115.