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A photo of Tanya V. Kalin.

Associate Professor, UC Department of Pediatrics

513-803-1201

513-636-2423

Biography & Affiliation

Research Interests

Transcriptional regulation of DNA replication and mitosis in tumor cells in vitro and in vivo; diagnostic, prevention and treatment of lung and prostate cancers.  

Academic Affiliation

Associate Professor, UC Department of Pediatrics

Department

Pulmonary Biology

Education

Postdoctoral research fellow: University of Chicago, Chicago, IL.

PhD: Institute of Immunology, Moscow , Russia, 1997.

MD: Moscow Medical University II, Moscow, Russia, 1992.

Publications

Postnatal alveologenesis depends on FOXF1 signaling in c-KIT1 endothelial progenitor cells. Ren, X; Ustiyan, V; Guo, M; Wang, G; Bolte, C; Zhang, Y; Xu, Y; Whitsett, JA; Kalin, TV; Kalinichenko, VV. American Journal of Respiratory and Critical Care Medicine. 2019; 200:1164-1176.

The S52F FOXF1 mutation inhibits STAT3 signaling and causes alveolar capillary dysplasia. Pradhan, A; Dunn, A; Ustiyan, V; Bolte, C; Wang, G; Whitsett, JA; Zhang, Y; Porollo, A; Hu, YC; Xiao, R; et al. American Journal of Respiratory and Critical Care Medicine. 2019; 200:1045-1056.

Targeted Inhibition of the Dual Specificity Phosphatases DUSP1 and DUSP6 Suppress MPNST Growth via JNK. Ramkissoon, A; Chaney, KE; Milewski, D; Williams, KB; Williams, RL; Choi, K; Miller, A; Kalin, TV; Pressey, JG; Szabo, S; et al. Clinical Cancer Research. 2019; 25:clincanres.3224.2018-clincanres.3224.2018.

The FOXM1 Inhibitor RCM-1 Decreases Carcinogenesis and Nuclear beta-Catenin. Shukla, S; Milewski, D; Pradhan, A; Rama, N; Rice, K; Le, T; Flick, MJ; Vaz, S; Zhao, X; Setchell, KD; et al. Molecular Cancer Therapeutics. 2019; 18:1217-1229.

The Forkhead box F1 transcription factor inhibits collagen deposition and accumulation of myofibroblasts during liver fibrosis. Flood, HM; Bolte, C; Dasgupta, N; Sharma, A; Zhang, Y; Gandhi, CR; Kalin, TV; Kalinichenko, VV. Biology Open. 2019; 8:bio039800-bio039800.

BUILDING AND REGENERATING THE LUNG CELL BY CELL. Whitsett, JA; Kalin, TV; Xu, Y; Kalinichenko, VV. Physiological Reviews. 2019; 99:513-554.

FOXF1 transcription factor promotes lung morphogenesis by inducing cellular proliferation in fetal lung mesenchyme. Ustiyan, V; Bolte, C; Zhang, Y; Han, L; Xu, Y; Yutzey, KE; Zorn, AM; Kalin, TV; Shannon, JM; Kalinichenko, VV. Developmental Biology. 2018; 443:50-63.

FOXF1 Inhibits Pulmonary Fibrosis by Preventing CDH2-CDH11 Cadherin Switch in Myofibroblasts. Black, M; Milewski, D; Le, T; Ren, X; Xu, Y; Kalinichenko, VV; Kalin, TV. Cell Reports. 2018; 23:442-458.

Transcription Factors Regulating Embryonic Development of Pulmonary Vasculature. Bolte, C; Whitsett, JA; Kalin, TV; Kalinichenko, VV. In: Parthasarathi K, Ed. MOLECULAR AND FUNCTIONAL INSIGHTS INTO THE PULMONARY VASCULATURE. : SPRINGER INTERNATIONAL PUBLISHING AG; SPRINGER INTERNATIONAL PUBLISHING AG; 2018.

FOXM1 activates AGR2 and causes progression of lung adenomas into invasive mucinous adenocarcinomas. Milewski, D; Balli, D; Ustiyan, V; Le, T; Dienemann, H; Warth, A; Breuhahn, K; Whitsett, JA; Kalinichenko, VV; Kalin, TV. PLoS Genetics. 2017; 13:e1007097-e1007097.