A photo of Tanya V. Kalin.

Associate Professor, UC Department of Pediatrics

513-803-1201

513-636-2423

Biography & Affiliation

Research Interests

Transcriptional regulation of DNA replication and mitosis in tumor cells in vitro and in vivo; diagnostic, prevention and treatment of lung and prostate cancers.  

Academic Affiliation

Associate Professor, UC Department of Pediatrics

Divisions

Pulmonary Biology

Education

Postdoctoral research fellow: University of Chicago, Chicago, IL.

PhD: Institute of Immunology, Moscow , Russia, 1997.

MD: Moscow Medical University II, Moscow, Russia, 1992.

Publications

Selected Publication

Loss of FOXM1 in macrophages promotes pulmonary fibrosis by activating p38 MAPK signaling pathway. Goda, C; Balli, D; Black, M; Milewski, D; Le, T; Ustiyan, V; Ren, X; Kalinichenko, VV; Kalin, TV. PLoS Genetics. 2020; 16:e1008692-e1008692.

The FOXM1 Inhibitor RCM-1 Decreases Carcinogenesis and Nuclear beta-Catenin. Shukla, S; Milewski, D; Pradhan, A; Rama, N; Rice, K; Le, T; Flick, MJ; Vaz, S; Zhao, X; Setchell, KD; et al. Molecular Cancer Therapeutics. 2019; 18:1217-1229.

FOXF1 Inhibits Pulmonary Fibrosis by Preventing CDH2-CDH11 Cadherin Switch in Myofibroblasts. Black, M; Milewski, D; Le, T; Ren, X; Xu, Y; Kalinichenko, VV; Kalin, TV. Cell Reports. 2018; 23:442-458.

FOXM1 activates AGR2 and causes progression of lung adenomas into invasive mucinous adenocarcinomas. Milewski, D; Balli, D; Ustiyan, V; Le, T; Dienemann, H; Warth, A; Breuhahn, K; Whitsett, JA; Kalinichenko, VV; Kalin, TV. PLoS Genetics. 2017; 13:e1007097-e1007097.

FoxF1 and FoxF2 transcription factors synergistically promote rhabdomyosarcoma carcinogenesis by repressing transcription of p21(Cip1) CDK inhibitor. Milewski, D; Pradhan, A; Wang, X; Cai, Y; Le, T; Turpin, B; Kalinichenko, VV; Kalin, TV. Oncogene: Including Oncogene Reviews. 2017; 36:850-862.

SPDEF Inhibits Prostate Carcinogenesis by Disrupting a Positive Feedback Loop in Regulation of the Foxm1 Oncogene. Cheng, X; Black, M; Ustiyan, V; Le, T; Fulford, L; Sridharan, A; Medvedovic, M; Kalinichenko, VV; Whitsett, JA; Kalin, TV. PLoS Genetics. 2014; 10:e1004656-e1004656.

Foxm1 Expression in Prostate Epithelial Cells Is Essential for Prostate Carcinogenesis. Cai, Y; Balli, D; Ustiyan, V; Fulford, L; Hiller, A; Misetic, V; Zhang, Y; Paluch, AM; Waltz, SE; Kasper, S; et al. The Journal of biological chemistry. 2013; 288:22527-22541.

Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition. Balli, D; Ustiyan, V; Zhang, Y; Wang, I; Masino, AJ; Ren, X; Whitsett, JA; Kalinichenko, VV; Kalin, TV. The EMBO Journal. 2013; 32:231-244.

Foxm1 transcription factor is required for macrophage migration during lung inflammation and tumor formation. Balli, D; Ren, X; Chou, F; Cross, E; Zhang, Y; Kalinichenko, VV; Kalin, TV. Oncogene: Including Oncogene Reviews. 2012; 31:3875-3888.

Endothelial Cell-Specific Deletion of Transcription Factor FoxM1 Increases Urethane-Induced Lung Carcinogenesis. Balli, D; Zhang, Y; Snyder, J; Kalinichenko, VV; Kalin, TV. Cancer Research. 2011; 71:40-50.