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A photo of Vladimir Kalinichenko.

Professor, UC Department of Pediatrics

513-636-4822

513-636-2423

Biography & Affiliation

Clinical Interests

Lung development; cell proliferation; carcinogenesis; transcriptional regulation of gene expression.

Research Interests

Transcriptional regulation of epithelial and endothelial cell functions during lung embryonic development and lung carcinogenesis; winged helix/forkhead box (Fox) proteins and their role in regulating cell signaling pathways required for cellular proliferation, differentiation, motility and survival; identify and increase understanding of currently unknown mechanisms that cause human lung malformations and promote lung cancer formation.

Academic Affiliation

Professor, UC Department of Pediatrics

Departments

Pulmonary Biology, Developmental Biology, Perinatal Biology

Science Blog

Education

MD: Russian State Medical University, Moscow, Russia, 1993.

PhD: Russian State Medical University, Moscow, Russia, 1995.

Fellowship: From the European Soros Foundation, 1995.

Postdoctoral: University of Illinois at Chicago, Center for Molecular Biology, IL, 2000.

Postdoctoral: University of Illinois at Chicago, Department of Molecular Genetics, IL, 2002.

Publications

Identification of a novel arthritis-associated osteoclast precursor macrophage regulated by FoxM1. Hasegawa, T; Kikuta, J; Sudo, T; Matsuura, Y; Matsui, T; Simmons, S; Ebina, K; Hirao, M; Okuzaki, D; Yoshida, Y; et al. Nature Immunology. 2019; 20:1631-1643.

Postnatal alveologenesis depends on FOXF1 signaling in c-KIT1 endothelial progenitor cells. Ren, X; Ustiyan, V; Guo, M; Wang, G; Bolte, C; Zhang, Y; Xu, Y; Whitsett, JA; Kalin, TV; Kalinichenko, VV. American Journal of Respiratory and Critical Care Medicine. 2019; 200:1164-1176.

The S52F FOXF1 mutation inhibits STAT3 signaling and causes alveolar capillary dysplasia. Pradhan, A; Dunn, A; Ustiyan, V; Bolte, C; Wang, G; Whitsett, JA; Zhang, Y; Porollo, A; Hu, YC; Xiao, R; et al. American Journal of Respiratory and Critical Care Medicine. 2019; 200:1045-1056.

The FOXM1 Inhibitor RCM-1 Decreases Carcinogenesis and Nuclear beta-Catenin. Shukla, S; Milewski, D; Pradhan, A; Rama, N; Rice, K; Le, T; Flick, MJ; Vaz, S; Zhao, X; Setchell, KD; et al. Molecular Cancer Therapeutics. 2019; 18:1217-1229.

The Forkhead box F1 transcription factor inhibits collagen deposition and accumulation of myofibroblasts during liver fibrosis. Flood, HM; Bolte, C; Dasgupta, N; Sharma, A; Zhang, Y; Gandhi, CR; Kalin, TV; Kalinichenko, VV. Biology Open. 2019; 8:bio039800-bio039800.

BUILDING AND REGENERATING THE LUNG CELL BY CELL. Whitsett, JA; Kalin, TV; Xu, Y; Kalinichenko, VV. Physiological Reviews. 2019; 99:513-554.

Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation. Izumi, T; Imai, J; Yamamoto, J; Kawana, Y; Endo, A; Sugawara, H; Kohata, M; Asai, Y; Takahashi, K; Kodama, S; et al. Nature Communications. 2018; 9.

Highly Efficient In Vivo Targeting of the Pulmonary Endothelium Using Novel Modifications of Polyethylenimine: An Importance of Charge. Dunn, AW; Kalinichenko, VV; Shi, D. Advanced Healthcare Materials. 2018; 7:e1800876-1800876.

FOXF1 transcription factor promotes lung morphogenesis by inducing cellular proliferation in fetal lung mesenchyme. Ustiyan, V; Bolte, C; Zhang, Y; Han, L; Xu, Y; Yutzey, KE; Zorn, AM; Kalin, TV; Shannon, JM; Kalinichenko, VV. Developmental Biology. 2018; 443:50-63.

FOXF1 Inhibits Pulmonary Fibrosis by Preventing CDH2-CDH11 Cadherin Switch in Myofibroblasts. Black, M; Milewski, D; Le, T; Ren, X; Xu, Y; Kalinichenko, VV; Kalin, TV. Cell Reports. 2018; 23:442-458.