A photo of Vladimir Kalinichenko.

Professor, UC Department of Pediatrics

513-636-4822

513-636-2423

Biography & Affiliation

Clinical Interests

Lung development; cell proliferation; carcinogenesis; transcriptional regulation of gene expression.

Research Interests

Transcriptional regulation of epithelial and endothelial cell functions during lung embryonic development and lung carcinogenesis; winged helix/forkhead box (Fox) proteins and their role in regulating cell signaling pathways required for cellular proliferation, differentiation, motility and survival; identify and increase understanding of currently unknown mechanisms that cause human lung malformations and promote lung cancer formation.

Academic Affiliation

Professor, UC Department of Pediatrics

Divisions

Pulmonary Biology, Developmental Biology, Perinatal Biology

Science Blog

Early-Stage Progress for Bronchopulmonary Dysplasia Cell Therapy

Perinatal

Early-Stage Progress for Bronchopulmonary Dysplasia Cell Therapy

Vladimir V. Kalinichenko, MD, PhD8/12/2019

CRISPR-Edited Mice Help Reveal Potential Nanoparticle Treatment for ACDMPV

Rare Diseases

CRISPR-Edited Mice Help Reveal Potential Nanoparticle Treatment for ACDMPV

Vladimir V. Kalinichenko, MD, PhD8/12/2019

Education

MD: Russian State Medical University, Moscow, Russia, 1993.

PhD: Russian State Medical University, Moscow, Russia, 1995.

Fellowship: From the European Soros Foundation, 1995.

Postdoctoral: University of Illinois at Chicago, Center for Molecular Biology, IL, 2000.

Postdoctoral: University of Illinois at Chicago, Department of Molecular Genetics, IL, 2002.

Publications

Selected Publication

Postnatal alveologenesis depends on FOXF1 signaling in c-KIT1 endothelial progenitor cells. Ren, X; Ustiyan, V; Guo, M; Wang, G; Bolte, C; Zhang, Y; Xu, Y; Whitsett, JA; Kalin, TV; Kalinichenko, VV. American Journal of Respiratory and Critical Care Medicine. 2019; 200:1164-1176.

The S52F FOXF1 mutation inhibits STAT3 signaling and causes alveolar capillary dysplasia. Pradhan, A; Dunn, A; Ustiyan, V; Bolte, C; Wang, G; Whitsett, JA; Zhang, Y; Porollo, A; Hu, Y; Xiao, R; et al. American Journal of Respiratory and Critical Care Medicine. 2019; 200:1045-1056.

The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice. Sun, L; Ren, X; Wang, I; Pradhan, A; Zhang, Y; Flood, HM; Han, B; Whitsett, JA; Kalin, TV; Kalinichenko, VV. Science Signaling. 2017; 10:eaai8583-eaai8583.

FOXF1 maintains endothelial barrier function and prevents edema after lung injury. Cai, Y; Bolte, C; Le, T; Goda, C; Xu, Y; Kalin, TV; Kalinichenko, VV. Science Signaling. 2016; 9:ra40-ra40.

FOXF1 Transcription Factor Is Required for Formation of Embryonic Vasculature by Regulating VEGF Signaling in Endothelial Cells. Ren, X; Ustiyan, V; Pradhan, A; Cai, Y; Havrilak, JA; Bolte, CS; Shannon, JM; Kalin, TV; Kalinichenko, VV. Circulation Research. 2014; 115:709-720.

FOXM1 Promotes Allergen-Induced Goblet Cell Metaplasia and Pulmonary Inflammation. Ren, X; Shah, TA; Ustiyan, V; Zhang, Y; Shinn, J; Chen, G; Whitsett, JA; Kalin, TV; Kalinichenko, VV. Molecular and Cellular Biology. 2013; 33:371-386.

Foxm1 Mediates Cross Talk between Kras/Mitogen-Activated Protein Kinase and Canonical Wnt Pathways during Development of Respiratory Epithelium. Wang, I; Snyder, J; Zhang, Y; Lander, J; Nakafuku, Y; Lin, J; Chen, G; Kalin, TV; Whitsett, JA; Kalinichenko, VV. Molecular and Cellular Biology. 2012; 32:3838-3850.

Forkhead Box m1 transcription factor is required for perinatal lung function. Kalin, TV; Wang, I; Meliton, L; Zhang, Y; Wert, SE; Ren, X; Snyder, J; Bell, SM; Jr, GL; Whitsett, JA; et al. Proceedings of the National Academy of Sciences of USA. 2008; 105:19330-19335.

Forkhead box F1 is essential for migration of mesenchymal cells and directly induces integrin-beta3 expression. Malin, D; Kim, I; Boetticher, E; Kalin, TV; Ramakrishna, S; Meliton, L; Ustiyan, V; Zhu, X; Kalinichenko, VV. Molecular and Cellular Biology. 2007; 27:2486-2498.

Forkhead Box M1 Transcription Factor Drives Liver Inflammation Linking to Hepatocarcinogenesis in Mice. Kurahashi, T; Yoshida, Y; Ogura, S; Egawa, M; Furuta, K; Hikita, H; Kodama, T; Sakamori, R; Kiso, S; Kamada, Y; et al. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2020; 9:425-446.