Respiratory lung disorders, such as Bronchopulmonary dysplasia (BPD), Acute Respiratory Distress Syndrome (ARDS) and Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV), are among leading causes of death in newborns and infants in the United States. Often this is due to prematurity or congenital lung abnormalities. As such, research in lung regeneration can help improve the health outcomes of children with BPD, ARDS, ACDMPV and other pediatric respiratory disorders.
I’m a senior investigator with long-standing interest in transcriptional regulation for lung development and lung injury or repair. My research and clinical interests include pediatric and adult pulmonary disorders, such as:
In our lab, my colleagues and I are attempting to uncover the molecular mechanisms responsible for lung development and lung regeneration after injury. We are developing new cell-based treatments for pediatric and adult pulmonary diseases. Furthermore, we are working with nanoparticle delivery systems for gene therapy. To advance lung regenerative medicine, we are designing bioengineered lung tissue, which includes embryonic stem cell (ESC)-derived airways, alveoli and vasculature for future medical applications.
Recent discoveries in my lab include:
My postdoctoral training in lung biology influenced my research interests today. Throughout my research career, I have been passionate about finding molecular and cellular mechanisms needed for lung development and lung repair after injury. In my laboratory, my colleagues and I were the first to discover the role of Forkhead Box (FOX) transcription factors FOXF1, FOXM1 and FOXF2 in the lungs. We took part in identifying and characterizing several FOXF1 mutations in ACDMPV patients and generating multiple mouse models for ACDMPV by inserting human FOXF1 mutations into the mouse genome.
Recognition and awards I’ve received include:
I have more than 20 years’ experience in the pulmonary field and started working for the Cincinnati Children’s Hospital Medical Center in 2007 after moving my lab from the University of Chicago. My research has been published in the American Journal of Respiratory and Critical Care Medicine, Proceedings of the National Academy of Sciences of the USA, Circulation Research and Science Signaling among other journals.
MD: Russian State Medical University, Moscow, Russia, 1993.
PhD: Russian State Medical University, Moscow, Russia, 1995.
Fellowship: From the European Soros Foundation, 1995.
Postdoctoral: University of Illinois at Chicago, Center for Molecular Biology, IL, 2000.
Postdoctoral: University of Illinois at Chicago, Department of Molecular Genetics, IL, 2002.
Lung development; cell proliferation; carcinogenesis; transcriptional regulation of gene expression.
Transcriptional regulation of epithelial and endothelial cell functions during lung embryonic development and lung carcinogenesis; winged helix/forkhead box (Fox) proteins and their role in regulating cell signaling pathways required for cellular proliferation, differentiation, motility and survival; identify and increase understanding of currently unknown mechanisms that cause human lung malformations and promote lung cancer formation.
Postnatal Alveologenesis Depends on FOXF1 Signaling in c-KIT+ Endothelial Progenitor Cells. American Journal of Respiratory and Critical Care Medicine. 2019; 200:1164-1176.
The S52F FOXF1 Mutation Inhibits STAT3 Signaling and Causes Alveolar Capillary Dysplasia. American Journal of Respiratory and Critical Care Medicine. 2019; 200:1045-1056.
FOXF1 maintains endothelial barrier function and prevents edema after lung injury. Science Signaling. 2016; 9.
FOXF1 transcription factor is required for formation of embryonic vasculature by regulating VEGF signaling in endothelial cells. Circulation Research. 2014; 115:709-720.
FOXM1 promotes allergen-induced goblet cell metaplasia and pulmonary inflammation. Molecular and Cellular Biology. 2013; 33:371-386.
Foxm1 mediates cross talk between Kras/mitogen-activated protein kinase and canonical Wnt pathways during development of respiratory epithelium. Molecular and Cellular Biology. 2012; 32:3838-3850.
Forkhead Box m1 transcription factor is required for perinatal lung function. Proceedings of the National Academy of Sciences of the United States of America. 2008; 105:19330-19335.
Forkhead box F1 is essential for migration of mesenchymal cells and directly induces integrin-beta3 expression. Molecular and Cellular Biology. 2007; 27:2486-2498.
Hedgehog and PDGF Collaborate to Guide Fibroblasts During Alveolarization. American Journal of Respiratory Cell and Molecular Biology. 2023.
Vladimir V. Kalinichenko, MD, PhD9/30/2022
Vladimir V. Kalinichenko, MD, PhD4/19/2022
Vladimir V. Kalinichenko, MD, PhD6/11/2021
Vladimir V. Kalinichenko, MD, PhD8/12/2019
Vladimir V. Kalinichenko, MD, PhD8/12/2019