A photo of Adam Lane.

Adam Lane, PhD

  • Member, Division of Bone Marrow Transplantation and Immune Deficiency
  • Assistant Professor, UC Department of Pediatrics

About

Biography

Dr. Lane joined Cincinnati Children's in July 2013. He has published novel statistical methods in the areas of adaptive and optimal experimental designs with applications to phase I and phase II clinical trials. As a graduate student he received funding from the NIH to spend the fall semester of 2011 at the University of Cambridge in the Isaac Newton Institute for Mathematical Sciences. He has also received NSF travel awards to present his research at national and international conferences.

PhD: University of Missouri, Columbia, MO, 2013.

Interests

Clinical trials; survival analysis; structural equation modeling

Research Areas

Experimental Hematology and Cancer Biology, Cancer and Blood Diseases

Publications

Selected

Conditional information and inference in response-adaptive allocation designs. Lane, A. Statistics in Medicine. 2022; 41:390-406.

Selected

Adaptive designs for optimal observed Fisher information. Lane, A. Journal of the Royal Statistical Society. Series B: Statistical Methodology. 2020; 82:1029-1058.

Selected

Hydroxyurea Dose Escalation for Sickle Cell Anemia in Sub-Saharan Africa. John, CC; Opoka, RO; Latham, TS; Hume, HA; Nabaggala, C; Kasirye, P; Ndugwa, CM; Lane, A; Ware, RE. New England Journal of Medicine. 2020; 382:2524-2533.

Selected

Graphical data mining of cancer mechanisms with SEMA. Solmaz, M; Lane, A; Gonen, B; Akmamedova, O; Gunes, MH; Komurov, K. Computer Applications in the Biosciences. 2019; 35:4413-4418.

Selected

Hydroxyurea for Children with Sickle Cell Anemia in Sub-Saharan Africa. Santos, B; Bernardino, L; Luis, J; da Fonseca, R; Nassesa, L; Andre, DA D O; Cuhna, L; Bengui, AF; de Oliveira, V; Tshilolo, L; et al. New England Journal of Medicine. 2019; 380:121-131.

Selected

A comparative survey of functional footprints of EGFR pathway mutations in human cancers. Lane, A; Segura-Cabrera, A; Komurov, K. Oncogene. 2014; 33:5078-5089.

Selected

Diagnostic and risk criteria for HSCT-associated thrombotic microangiopathy: a study in children and young adults. Jodele, S; Davies, SM; Lane, A; Khoury, J; Dandoy, C; Goebel, J; Myers, K; Grimley, M; Bleesing, J; El-Bietar, J; et al. Blood. 2014; 124:645-653.

Selected

Information in a two-stage adaptive optimal design. Lane, A; Yao, P; Flournoy, N. Journal of Statistical Planning and Inference. 2014; 144:173-187.

Selected

Two-Stage Adaptive Optimal Design with Fixed First-Stage Sample Size. Lane, A; Flournoy, N. Journal of Probability and Statistics. 2012; 2012:1-15.

Volumetric endpoints in diffuse intrinsic pontine glioma: comparison to cross-sectional measures and outcome correlations in the International DIPG/DMG Registry. Lazow, MA; Nievelstein, MT; Lane, A; Bandopadhayhay, P; DeWire-Schottmiller, M; Fouladi, M; Glod, JW; Greiner, RJ; Hoffman, LM; Hummel, TR; et al. Neuro-Oncology. 2022; 24:1598-1608.