A photo of Adam Lane.

Adam Lane, PhD

  • Member, Division of Bone Marrow Transplantation and Immune Deficiency
  • Assistant Professor, UC Department of Pediatrics



Dr. Lane joined Cincinnati Children's in July 2013. He has published novel statistical methods in the areas of adaptive and optimal experimental designs with applications to phase I and phase II clinical trials. As a graduate student he received funding from the NIH to spend the fall semester of 2011 at the University of Cambridge in the Isaac Newton Institute for Mathematical Sciences. He has also received NSF travel awards to present his research at national and international conferences.

PhD: University of Missouri, Columbia, MO, 2013.


Clinical trials; survival analysis; structural equation modeling

Research Areas

Experimental Hematology and Cancer Biology, Cancer and Blood Diseases



Conditional information and inference in response-adaptive allocation designs. Lane, A. Statistics in Medicine. 2022; 41:390-406.


Adaptive designs for optimal observed Fisher information. Lane, A. Journal of the Royal Statistical Society. Series B: Statistical Methodology. 2020; 82:1029-1058.


Hydroxyurea Dose Escalation for Sickle Cell Anemia in Sub-Saharan Africa. John, CC; Opoka, RO; Latham, TS; Hume, HA; Nabaggala, C; Kasirye, P; Ndugwa, CM; Lane, A; Ware, RE. New England Journal of Medicine. 2020; 382:2524-2533.


Graphical data mining of cancer mechanisms with SEMA. Solmaz, M; Lane, A; Gonen, B; Akmamedova, O; Gunes, MH; Komurov, K. Computer Applications in the Biosciences. 2019; 35:4413-4418.


Hydroxyurea for Children with Sickle Cell Anemia in Sub-Saharan Africa. Santos, B; Bernardino, L; Luis, J; da Fonseca, R; Nassesa, L; Andre, DA D O; Cuhna, L; Bengui, AF; de Oliveira, V; Tshilolo, L; et al. New England Journal of Medicine. 2019; 380:121-131.


A comparative survey of functional footprints of EGFR pathway mutations in human cancers. Lane, A; Segura-Cabrera, A; Komurov, K. Oncogene. 2014; 33:5078-5089.


Diagnostic and risk criteria for HSCT-associated thrombotic microangiopathy: a study in children and young adults. Jodele, S; Davies, SM; Lane, A; Khoury, J; Dandoy, C; Goebel, J; Myers, K; Grimley, M; Bleesing, J; El-Bietar, J; et al. Blood. 2014; 124:645-653.


Information in a two-stage adaptive optimal design. Lane, A; Yao, P; Flournoy, N. Journal of Statistical Planning and Inference. 2014; 144:173-187.


Two-Stage Adaptive Optimal Design with Fixed First-Stage Sample Size. Lane, A; Flournoy, N. Journal of Probability and Statistics. 2012; 2012:1-15.

Hydroxyurea treatment is associated with lower malaria incidence in children with sickle cell anemia in sub-Saharan Africa. Olupot-Olupot, P; Tomlinson, G; Williams, TN; Tshilolo, L; Santos, B; Smart, LR; McElhinney, K; Howard, TA; Aygun, B; Stuber, SE; et al. Blood. 2023; 141:1402-1410.