A photo of Russell Ware.

Director, Division of Hematology

Institute Co-Director, Cancer and Blood Diseases Institute

Director, Global Health Center                                     

Marjory J. Johnson Chair of Hematology Translational Research

Professor, UC Department of Pediatrics



Board Certified

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My Biography & Research


Russell Ware, MD, PhD, has been involved with a wide variety of clinical and translational hematology research projects for over 25 years, but his primary interests have focused on sickle cell disease. Dr. Ware has substantial personal experience with directing patient-oriented research, and he currently runs an NIH-funded laboratory effort that investigates genetic modifiers of sickle cell disease. The main focus of his lab research is to understand the phenotypic variability that occurs with hydroxyurea treatment, through the study of hydroxyurea pharmacokinetics, pharmacodynamics, pharmacogenetics, and pharmacogenomics. Dr. Ware is also the national principal investigator for several NIH-funded multicenter sickle cell clinical trials, including the recently completed Stroke With Transfusions Changing to Hydroxyurea (SWiTCH), and the current TCD With Transfusions Changing to Hydroxyurea (TWiTCH) and Sparing Conversion to Abnormal TCD Elevations (SCATE) studies that include non-US clinical sites. Most recently, Dr. Ware has moved his research efforts into the international arena, starting SCD pilot screening programs in Angola, and now conducting clinical trials to determine the safety and efficacy of hydroxyurea in developing countries.

Dr. Ware has been elected by peers for inclusion in the Best Doctors in America List.

Academic Affiliation

Professor, UC Department of Pediatrics


Cancer and Blood Diseases, Sickle Cell and Hemoglobin Disorders, Hematology, Cancer and Blood Diseases, Global Health

My Locations

My Education

MD: Duke University School of Medicine, Durham, NC, 1979-83.

Residency: Baylor College of Medicine, Houston, TX, 1983-86.

Fellowship: Duke Medical Center, Durham, NC, 1986-89.

PhD: Duke University School of Medicine, Durham, NC, 1987-91.

Certification: Pediatric Hematology/Oncology.

My Publications

Perceived benefits and risks of participation in a clinical trial for Ugandan children with sickle cell anemia. Carman, AS; Sautter, C; Anyanwu, JN; Ssemata, AS; Opoka, RO; Ware, RE; Rujumba, J; John, CC. Pediatric Blood and Cancer. 2020; 67.

Zinc for Infection Prevention in Sickle Cell Anemia (ZIPS): study protocol for a randomized placebo-controlled trial in Ugandan children with sickle cell anemia. Datta, D; Namazzi, R; Conroy, AL; Cusick, SE; Hume, HA; Tagoola, A; Ware, RE; Opoka, RO; John, CC. Trials. 2019; 20.

Newborn screening with sickle cell point of care: A valuable resource in low-income settings. Ware, RE; Odame, I. Pediatrics. 2019; 144:e20191681-e20191681.

A Phase 3 Randomized Trial of Voxelotor in Sickle Cell Disease. Vichinsky, E; Hoppe, CC; Ataga, KI; Ware, RE; Nduba, V; El-Beshlawy, A; Hassab, H; Achebe, MM; Alkindi, S; Brown, RC; et al. The New England journal of medicine. 2019; 381:509-519.

Hydroxyurea for children with sickle cell anemia: Prescribe it early and often. Ware, RE; McGann, PT; Quinn, CT. Pediatric Blood and Cancer. 2019; 66.

Robust clinical and laboratory response to hydroxyurea using pharmacokinetically guided dosing for young children with sickle cell anemia. McGann, PT; Niss, O; Dong, M; Marahatta, A; Howard, TA; Mizuno, T; Lane, A; Kalfa, TA; Malik, P; Quinn, CT; et al. American Journal of Hematology. 2019; 94:871-879.

Sickle cell screening in Uganda: High burden, human immunodeficiency virus comorbidity, and genetic modifiers. Kiyaga, C; Hernandez, AG; Ssewanyana, I; Schaefer, BA; McElhinney, KE; Ndeezi, G; Howard, TA; Ndugwa, CM; Ware, RE; Aceng, JR. Pediatric Blood and Cancer. 2019; 66.

Elevated tricuspid regurgitation velocity in congenital hemolytic anemias: Prevalence and laboratory correlates. Yates, AM; Joshi, VM; Aygun, B; Moen, J; Smeltzer, MP; Govindaswamy, D; Dowdy, J; Cotton, A; Kang, G; Ware, RE; et al. Pediatric Blood and Cancer. 2019; 66:e27717-e27717.

Preface Pediatric Hematology. Grace, RF; Ware, RE. Hematology/Oncology Clinics of North America. 2019; 33:xiii-xiv.

Your tired, your poor, your huddled masses. Ware, RE; Thornburg, CD. Blood. 2019; 133:2010-2011.