A photo of Russell Ware.

Director, Division of Hematology

Institute Co-Executive Director, Cancer and Blood Diseases Institute

Director, Global Health Center                                     

Marjory J. Johnson Chair of Hematology Translational Research

Professor, UC Department of Pediatrics

513-517-2344

513-803-8941

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My Biography & Research

Biography

As a practicing pediatric hematologist for 30 years, I provide care for children with a wide variety of hematological disorders. My primary focus is the evaluation and management of care for children with sickle cell anemia and other hemolytic anemias. I also treat children who present with other forms of anemia, as well as neutropenia or thrombocytopenia.

When I began my career, there were almost no treatments available for sickle cell anemia. We now have many new diagnostic tools and novel approaches to help improve our young patients' lives. I have always enjoyed providing direct clinical care as well as performing laboratory investigations that lead to more effective care and improved outcomes for our children.

My research goals are to determine the best ways to use hydroxyurea for children with sickle cell anemia and to understand why some children respond better than others. I’m investigating the genetic basis for treatment outcomes and hope to optimize hydroxyurea treatment for each patient. Transforming the clinical care of children with sickle cell anemia across the world, through the widespread use of hydroxyurea, is my long-term research goal.

Our studies include both translational and clinical research. I have led several National Institutes of Health (NIH)-funded trials of hydroxyurea to prevent stroke in children with sickle cell anemia, demonstrating the efficacy of this simple daily oral medication. I’m also investigating the use of hydroxyurea in low-resource settings, focusing on sub-Saharan Africa and the Caribbean. Our exciting results have shown the feasibility, safety and benefits of hydroxyurea in these settings, which could potentially transform the treatment landscape for sickle cell anemia worldwide. Some of my research trials also include point-of-care diagnostics and optimizing hydroxyurea treatment through individualized dosing.

Improving the care and health of children with sickle cell anemia has been a rewarding career goal. However, taking what we have learned in the United States and bringing this knowledge to low-resource countries has been even more gratifying. With support from the Cincinnati Children's Research Foundation, we have established productive global partnerships with local partners in six sub-Saharan countries and two Caribbean islands. These collaborations are changing the approach to diagnosing and treating sickle cell anemia worldwide.

Academic Affiliation

Professor, UC Department of Pediatrics

Clinical Divisions

Cancer and Blood Diseases, Sickle Cell and Hemoglobin Disorders

Research Divisions

Hematology, Cancer and Blood Diseases, Global Health



Blog Posts

In NEJM: Dose Escalation Best Approach for Sickle Cell Med in Africa

Rare Diseases

In NEJM: Dose Escalation Best Approach for Sickle Cell Med in Africa

Russell E. Ware, MD, PhD6/25/2020

Moms with Sickle Cell Anemia Can Take Life-Saving Med and Breastfeed Baby

Rare Diseases

Moms with Sickle Cell Anemia Can Take Life-Saving Med and Breastfeed Baby

Russell E. Ware, MD, PhD3/30/2020

Our 2019 Research Annual Report

Genomics and Development

Our 2019 Research Annual Report

Russell E. Ware, MD, PhD, John Hogenesch, PhD ...2/4/2020

Sickle Cell Breakthrough: A Pill to Replace Blood Transfusions

Rare Diseases

Sickle Cell Breakthrough: A Pill to Replace Blood Transfusions

Russell E. Ware, MD, PhD6/28/2019

My Education

MD: Duke University School of Medicine, Durham, NC, 1979-83.

Residency: Baylor College of Medicine, Houston, TX, 1983-86.

Fellowship: Duke Medical Center, Durham, NC, 1986-89.

PhD: Duke University School of Medicine, Durham, NC, 1987-91.

Certification: Pediatric Hematology/Oncology.

My Publications

AnemoCheck-LRS: an optimized, color-based point-of-care test to identify severe anemia in limited-resource settings. Perez-Plazola, MS; Tyburski, EA; Smart, LR; Howard, TA; Pfeiffer, A; Ware, RE; Lam, WA; McGann, PT. BMC Medicine. 2020; 18.

Surveillance for sickle cell disease, united republic of tanzania. Ambrose, EE; Smart, LR; Charles, M; Hernandez, AG; Latham, T; Hokororo, A; Beyanga, M; Howard, TA; Kamugisha, E; McElhinney, KE; et al. Bulletin of the World Health Organization. 2020; 98:859-868.

Novel dose escalation to predict treatment with hydroxyurea (NDEPTH): A randomized controlled trial of a dose-prediction equation to determine maximum tolerated dose of hydroxyurea in pediatric sickle cell disease. George, A; Dinu, B; Estrada, N; Minard, CG; Hurwitz, R; Mahoney, DH; Yates, AM; Vaughan, M; Carmouche, A; Airewele, G; et al. American Journal of Hematology. 2020; 95:E242-E244.

Hydroxyurea Exposure in Lactation: a Pharmacokinetics Study (HELPS). Ware, RE; Marahatta, A; Ware, JL; McElhinney, K; Dong, M; Vinks, AA. The Journal of Pediatrics. 2020; 222:236-239.

β-Thalassemia pathogenic variants in a cohort of children from the East African coast. Macharia, AW; Mochamah, G; Uyoga, S; Ndila, CM; Nyutu, G; Tendwa, M; Nyatichi, E; Makale, J; Ware, RE; Williams, TN. Molecular Genetics and Genomic Medicine. 2020; 8.

Empowering newborn screening programs in African countries through establishment of an international collaborative effort. Jr, TB L; Lloyd-Puryear, MA; Ohene-Frempong, K; Ware, RE; Padilla, CD; Ambrose, EE; Barkat, A; Ghazal, H; Kiyaga, C; Mvalo, T; et al. Journal of Community Genetics. 2020; 11:253-268.

Hydroxyurea dose escalation for sickle cell Anemia in sub-Saharan Africa. John, CC; Opoka, RO; Latham, TS; Hume, HA; Nabaggala, C; Kasirye, P; Ndugwa, CM; Lane, A; Ware, RE. The New England journal of medicine. 2020; 382:2524-2533.

Hydroxyurea to lower transcranial Doppler velocities and prevent primary stroke: The Uganda NOHARM sickle cell anemia cohort. Opoka, RO; Hume, HA; Latham, TS; Lane, A; Williams, O; Tymon, J; Nakafeero, M; Kasirye, P; Ndugwa, CM; John, CC; et al. Haematologica: the hematology journal. 2020; 105:e272-e275.

Effective use of hydroxyurea for sickle cell anemia in low-resource countries. Power-Hays, A; Ware, RE. Current Opinion in Hematology. 2020; 27:172-180.

Perceived benefits and risks of participation in a clinical trial for Ugandan children with sickle cell anemia. Carman, AS; Sautter, C; Anyanwu, JN; Ssemata, AS; Opoka, RO; Ware, RE; Rujumba, J; John, CC. Pediatric Blood and Cancer. 2020; 67.