A photo of Luke Smart.

Assistant Professor, UC Department of PediatricsUC Department of Internal Medicine


Board Certified

My Biography & Research


My clinical specialty is non-malignant hematological conditions, especially those that affect patients across the life span. I completed a dual residency training in internal medicine and pediatrics and a dual fellowship training in pediatric hematology/oncology and adult hematology. In my practice, I see patients at Cincinnati Children's and the University of Cincinnati (UC). I am the director of the adult sickle cell clinic at UC.

I enjoy working with patients across the age-span and with their family members, whether they are the parents of a pediatric patient or the children of an adult patient. I like educating patients so they understand how the healthcare system functions, how their disease works and how to advocate for themselves. I enjoy answering difficult questions and working with a team of people to provide the optimal care that I could not achieve alone.

My research interest is hematological conditions in low-resource settings, especially sickle cell disease in sub-Saharan Africa. I have described the epidemiology of diseases, investigated new diagnostic tests and studied the best way to treat these diseases in sub-Saharan Africa. I became interested in this work when I completed a four-year global health fellowship under Weill Cornell Medicine. I spent those years living in Tanzania at a referral and teaching hospital, working as a clinician, educator and researcher. I saw that hematological disease in general, and sickle cell disease specifically, were prevalent and painful conditions that often led to hospitalization and death. I enjoyed working with local faculty who focused on treatments for hematological disorders. Overall, my goal is to improve the lives of people with hematological diseases, especially sickle cell disease, in low-resource settings.

I have been privileged to participate in two American Society of Hematology training programs. I was a recipient of a Research Training Award for Fellows in my final year of fellowship and was accepted into the Clinical Research Training Institute as a junior faculty. Both of these are tremendous honors and they provided significant support for my early research career.

During my fellowship, I also received a Thrasher Foundation early career award that allowed me to investigate a novel color-based point-of-care diagnostic device for anemia in Africa. Performing clinical research in low-resource settings can be challenging. Still, it's essential that we conduct research where people, especially children, are most affected by disease to improve children's lives around the world.

Clinical Interests

Hematology/oncology; global hematology; clinical research; non-malignant hematology; adolescent and young adult hematology/oncology; transition to adult care

Research Interests

Dr. Smart's research time is focused on collaborative clinical research in Tanzania. Together with colleagues from Tanzania they have determined the district prevalence of sickle cell disease in northwest Tanzania, tested accuracy and operability of diagnostic devices for anemia and sickle cell disease, and are now investigating the use of hydroxyurea for primary stroke prevention in sickle cell disease in Tanzania. He has received funding from the Cincinnati Children's Research Foundation, the Thrasher Foundation, the American Society of Hematology, and the NIH.

Academic Affiliation

Assistant Professor, UC Department of PediatricsUC Department of Internal Medicine

Clinical Divisions

Cancer and Blood Diseases

Research Divisions


Blog Posts

My Locations

My Education

Undergraduate: University of Maryland, Baltimore County, Baltimore, MD.

MD: University of Maryland School of Medicine, Baltimore, MD.

Residency: Internal Medicine/Pediatrics, University of Rochester/Strong Memorial Hospital, Rochester, NY.

My Publications

Linkage to Care Intervention to Improve Post-Hospital Outcomes Among Children with Sickle Cell Disease in Tanzania: A Pilot Study. Hau, DK; Ambrose, EE; Smart, LR; Kayange, NM; Peck, RN. Journal of Pediatrics. 2021; 232:290-293.e1.

AnemoCheck-LRS: an optimized, color-based point-of-care test to identify severe anemia in limited-resource settings. Perez-Plazola, MS; Tyburski, EA; Smart, LR; Howard, TA; Pfeiffer, A; Ware, RE; Lam, WA; McGann, PT. BMC Medicine. 2020; 18.

Surveillance for sickle cell disease, United Republic of Tanzania. Ambrose, EE; Smart, LR; Charles, M; Hernandez, AG; Latham, T; Hokororo, A; Beyanga, M; Howard, TA; Kamugisha, E; McElhinney, KE; et al. Bulletin of the World Health Organization. 2020; 98:859-868.

Extremely high birth prevalence of sickle cell disease in rural Tanzania. Eastburg, L; Peckham, A; Kawira, E; Chirangi, B; Adler, D; Akungo, BD; Smart, LR; Ambrose, EE. Pediatric Blood and Cancer. 2020; 67.

Genetic Analysis in the Tanzania Sickle Surveillance Study (TS3): Modifiers of Sickle Cell Disease and Identification of Hemoglobin Variants. Smart, LR; Ambrose, EE; Charles, M; Hernandez, AG; Latham, TS; Hokororo, A; Beyanga, M; Kamugisha, E; Tebuka, E; Howard, TA; et al. Blood. 2019; 134:988-988.

Very severe anemia and one year mortality outcome after hospitalization in Tanzanian children: A prospective cohort study. Chami, N; Hau, DK; Masoza, TS; Smart, LR; Kayange, NM; Hokororo, A; Ambrose, EE; Moschovis, PP; Wiens, MO; Peck, RN. PLoS ONE. 2019; 14.

Parvovirus B19 Is Associated with a Significant Decrease in Hemoglobin Level among Children <5 Years of Age with Anemia in Northwestern Tanzania. Tizeba, YA; Mirambo, MM; Kayange, N; Mhada, T; Ambrose, EE; Smart, LR; Mshana, SE. Journal of Tropical Pediatrics. 2018; 64:479-487.

Post-hospital mortality in children aged 2-12 years in Tanzania: A prospective cohort study. Hau, DK; Chami, N; Duncan, A; Smart, LR; Hokororo, A; Kayange, NM; Peck, RN. PLoS ONE. 2018; 13.

Sickle cell disease: Translating clinical care to low-resource countries through international research collaborations. Smart, LR; Hernandez, AG; Ware, RE. Seminars in Hematology. 2018; 55:102-112.

Simultaneous point-of-care detection of anemia and sickle cell disease in Tanzania: the RAPID study. Smart, LR; Ambrose, EE; Raphael, KC; Hokororo, A; Kamugisha, E; Tyburski, EA; Lam, WA; Ware, RE; McGann, PT. Annals of Hematology. 2018; 97:239-246.