A photo of Daniel Lucas.

Member, Division of Experimental Hematology & Cancer Biology

Assistant Professor, UC Department of Pediatrics


Biography & Affiliation


Daniel Lucas, PhD's, area of expertise is regulation of hematopoiesis with a specific focus in using imaging and mouse genetics to understand the bidirectional communication between hematopoietic stem cells and their niches and how this communication regulates steady-state and regenerative hematopoiesis.

Academic Affiliation

Assistant Professor, UC Department of Pediatrics


Cancer and Blood Diseases


BSc: Universidad Autonoma de Madrid, Madrid, Spain.

PhD: Universidad Autonoma de Madrid, Madrid, Spain.


Unraveling bone marrow architecture. Lucas, D; Salomonis, N; Grimes, HL. Nature Cell Biology. 2020; 22:5-6.

Hox11 expressing regional skeletal stem cells are progenitors for osteoblasts, chondrocytes and adipocytes throughout life. Pineault, KM; Song, JY; Kozloff, KM; Lucas, D; Wellik, DM. Nature Communications. 2019; 10.

A Tie2-Notch1 signaling axis regulates regeneration of the endothelial bone marrow niche. Shao, L; Sottoriva, K; Palasiewicz, K; Zhang, J; Hyun, J; Soni, SS; Paik, NY; Gao, X; Cuervo, H; Malik, AB; et al. Haematologica: the hematology journal. 2019; 104:2164-2177.

Neutrophils as regulators of the hematopoietic niche. Cossio, I; Lucas, D; Hidalgo, A. Blood. 2019; 133:2140-2148.

Leukocyte Trafficking and Regulation of Murine Hematopoietic Stem Cells and Their Niches. Lucas, D. Frontiers in Immunology. 2019; 10.

Dynamic Regulation of Hematopoietic Stem Cells by Bone Marrow Niches. May, M; Slaughter, A; Lucas, D. Current stem cell reports. 2018; 4:201-208.

Granulocyte-derived TNFα promotes vascular and hematopoietic regeneration in the bone marrow. Bowers, E; Slaughter, A; Frenette, PS; Kuick, R; Pello, OM; Lucas, D. Nature Medicine. 2018; 24:95-102.

The orphan nuclear receptor TR4 regulates erythroid cell proliferation and maturation. Lee, MP; Tanabe, O; Shi, L; Jearawiriyapaisarn, N; Lucas, D; Engel, JD. Blood. 2017; 130:2537-2547.

Cholinergic Signals from the CNS Regulate G-CSF-Mediated HSC Mobilization from Bone Marrow via a Glucocorticoid Signaling Relay. Pierce, H; Zhang, D; Magnon, C; Lucas, D; Christin, JR; Huggins, M; Schwartz, GJ; Frenette, PS. Cell Stem Cell. 2017; 20:648-658.e4.

Regionally Restricted Hox Function in Adult Bone Marrow Multipotent Mesenchymal Stem/Stromal Cells. Rux, DR; Song, JY; Swinehart, IT; Pineault, KM; Schlientz, AJ; Trulik, KG; Goldstein, SA; Kozloff, KM; Lucas, D; Wellik, DM. Developmental Cell. 2016; 39:653-666.