Dr. Lim is a computational scientist by training. After getting his PhD, he was fascinated by the complex yet highly organized biological system thereby switched to bioinformatics field. He did postdoctoral research at the University of Pennsylvania, where he studied transcriptional regulations in various metabolic systems such as pancreas, adipose tissues, and liver. After that, he joined the Division of Biomedical Informatics at the Cincinnati Children's Hospital Medical Center as an assistant professor to start a regulatory genomics laboratory.

Dr. Lim investigates transcriptional regulations of gene expression in various context including but not limited to metabolism, development, pathogenesis, and pharmacogenomics. He specifically focuses on enhancer regulations and tries to explain their regulatory mechanisms. To this end, he integrates various levels of genomic, epigenomic, and transcriptomic information from high-throughput data (GRO-seq, RNA-seq, ChIP-seq, ChIP-exo, etc) to understand detailed enhancer architectures and their distinct functions.