Jaime L. Lopes, PhD

Director, Genetics and Genomics Diagnostic Laboratory, Division of Human Genetics
Assistant Professor, UC Department of Pediatrics

jaime.lopes@cchmc.org

About

MSc: Molecular Genetics of Human Disease, University College London, UK, 2012-2013.

PhD: Molecular Genetics and Genomics, Wayne State State University, Detroit, MI, 2014-2018.

Fellowship: Laboratory Genetics and genomics, Mayo Clinic, Rochester, MN, 2018-2021.

Interests

Molecular and cytogenetics

Services and Specialties

Human Genetics

Research Areas

Human Genetics

Publications

Identification of sex-specific genetic associations in response to opioid analgesics in a White, non-Hispanic cohort from Southeast Minnesota. Lopes, GS; Lopes, JL; Bielinski, SJ; Armasu, SM; Zhu, Y; Cavanaugh, DC; Moyer, AM; Jacobson, DJ; Wang, L; Jiang, R; et al. The Pharmacogenomics Journal. 2022; 22:117-123.

Germline mutations in apoptosis pathway genes in ovarian cancer; the functional role of a TP53I3 (PIG3) variant in ROS production and DNA repair. Chaudhry, SR; Lopes, J; Levin, NK; Kalpage, H; Tainsky, MA. Cell Death Discovery. 2021; 7:62.

Most noninvasive prenatal screens failing due to inadequate fetal cell free DNA are negative for trisomy when repeated. Lopes, JL; Lopes, GS; Enninga, EA L; Kearney, HM; Hoppman, NL; Rowsey, RA. Prenatal Diagnosis. 2020; 40:831-837.

Characterizing false-positive fluorescence in situ hybridization results by mate-pair sequencing in a patient with chronic myeloid leukemia and progression to myeloid blast crisis. Lopes, JL; Webley, M; Pitel, BA; Pearce, KE; Smadbeck, JB; Johnson, SH; Vasmatzis, G; Sukov, WR; Greipp, PT; Hoppman, NL; et al. Cancer genetics. 2020; 243:48-51.

Encyclopedia of Evolutionary Psychological Science. Lopes, J. In: Shackelford TK; Weekes-Shackelford VA, Ed. Encyclopedia of Evolutionary Psychological Science. Cham, Switzerland: Springer; 2020.

Unconventional Diagnosis Based on Somatic Findings through Germ Line Whole-Exome Sequencing. Lopes, JL; Rasmussen, KJ; Mehta, N; Boczek, NJ; Hasadsri, L. Clinical Chemistry (Washington, DC): international journal of molecular diagnostics and laboratory medicine. 2020; 66:48-51.

FANCM, RAD1, CHEK1 and TP53I3 act as BRCA-like tumor suppressors and are mutated in hereditary ovarian cancer. Lopes, JL; Chaudhry, S; Lopes, GS; Levin, NK; Tainsky, MA. Cancer genetics. 2019; 235-236:57-64.