Long (Jason) Lu, PhD

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-8720

Fax 513-636-2056

Email long.lu@cchmc.org

Dr. Lu works in bioinformatics and systems biology. He focuses on using quantitative approaches from disciplines such as computer science and applied mathematics to analyze biomedical big data with the goal of addressing fundamental questions in biology and improving human health. In particular, he is interested in deciphering the human genetic blueprint, modeling complex biological systems (such as biomolecular networks and pathways), analyzing biomedical images and data mining on medical records. He developed a network-based approach that combines proteomics experiments and computational predictions to discover the subspecies in high-density lipoprotein (HDL) cholesterol and correlate them with cardiovascular protection function. Dr. Lu has also analyzed microbial genomes to facilitate drug discovery and development. Most recently, Dr. Lu’s lab has made progress in developing computational algorithms for analyzing MRI brain images.

BS: Biotechnology/Bioengineering, Peking University, Beijing, China.

PhD: Biochemistry, specialized in Computational Molecular Biology, Washington University School of Medicine, St. Louis, MO.

Postdoc: Research Associate, Bioinformatics, Yale University, New Haven, CT.

View Publications

Lu Y, Lu Y, Deng J, Peng H, Lu H, Lu LJ. A novel essential domain perspective for exploring gene essentiality. Bioinformatics. 2015 Sep 15;31(18):2921-9.

Heink A, Davidson WS, Swertfeger DK, Lu LJ, Shah AS. A Comparison of Methods To Enhance Protein Detection of Lipoproteins by Mass Spectrometry. J Proteome Res. 2015 Jul 2;14(7):2943-50.

Li H, Gordon SM, Zhu X, Deng J, Swertfeger DK, Davidson WS, Lu LJ. Network-Based Analysis on Orthogonal Separation of Human Plasma Uncovers Distinct High Density Lipoprotein Complexes. J Proteome Res. 2015 Aug 7;14(8):3082-94.

Cai WF, Liu GS, Lam CK, Florea S, Qian J, Zhao W, Pritchard T, Haghighi K, Lebeche D, Lu LJ, Deng J, Fan GC, Hajjar RJ, Kranias EG. Up-regulation of micro-RNA765 in human failing hearts is associated with post-transcriptional regulation of protein phosphatase inhibitor-1 and depressed contractility. Eur J Heart Fail. 2015 Aug;17(8):782-93.

Gordon SM, Li H, Zhu X, Shah AS, Lu LJ, Davidson WS. A comparison of the mouse and human lipoproteome: suitability of the mouse model for studies of human lipoproteins. J Proteome Res. 2015 Jun 5;14(6):2686-95.

Lu Y, Deng J, Rhodes JC, Lu H, Lu LJ. Predicting essential genes for identifying potential drug targets in Aspergillus fumigatus. Comput Biol Chem. 2014 Jun;50:29-40.

Krishnan K, Ren Z, Losada L, Nierman WC, Lu LJ, Askew DS. Polysome profiling reveals broad translatome remodeling during endoplasmic reticulum (ER) stress in the pathogenic fungus Aspergillus fumigatus. BMC Genomics. 2014 Feb 25;15:159.

Tan L, Chen Y, Maloney TC, Caré MM, Holland SK, Lu LJ. Combined analysis of sMRI and fMRI imaging data provides accurate disease markers for hearing impairment. Neuroimage Clin. 2013 Oct 11;3:416-28.

Chen Y, Storrs J, Tan L, Mazlack LJ, Lee JH, Lu LJ. Detecting brain structural changes as biomarker from magnetic resonance images using a local feature based SVM approach. J Neurosci Methods. 2014 Jan 15;221:22-31.

Gordon SM, Deng J, Tomann AB, Shah AS, Lu LJ, Davidson WS. Multi-dimensional co-separation analysis reveals protein-protein interactions defining plasma lipoprotein subspecies. Mol Cell Proteomics. 2013 Nov;12(11):3123-34.