A photo of Xinhua Lin.

Professor, UC Department of Pediatrics

513-636-2144

513-636-4317

Biography & Affiliation

Biography

Xinhua Lin, PhD, completed his doctoral work at the Washington University with Thomas. F. Deuel, where he studied the transcriptional regulation of platelet-derived growth factor A-chain gene. He then went to the Dr. Norbert Perrimon lab at Harvard Medical School, where he initiated his work on the role of heparan sulfate proteoglycan in cell-cell signaling in drosophila.

Dr. Lin has identified and characterized two mutations, sugarless and sulfateless, which occur in the genes that encode essential enzymes for the biosynthesis of heparin/heparin sulfate glycosaminoglycan (HSPG). Analyses of these mutants led to the demonstration that HSPGs play critical roles in the signaling activities of several growth factors including Wg, Hh and FGF. Dr. Lin further demonstrated that glypican members of HSPG play key roles in Wg signaling and the formation of Wg morphogen gradient. He became an assistant professor in April, 2000, at Cincinnati Children's Hospital Medical Center. His lab is interested in elucidating the molecular mechanisms of cell-cell signaling, focusing on the role of HSPG in signaling and the morphogen gradient formation of the Wg and Hh proteins.

Research Interests

Understanding the mechanisms governing the regulation of cell-cell signaling by extracellular molecules that play essential roles in coordinating cell growth and differentiation; the role of heparan sulfate proteoglycans (HSPGs) in cell-cell signaling; identification of molecules that modulate the function of two key signaling molecules, Wnt/Wingless (Wg), Hedgehog (Hh).

Academic Affiliation

Professor, UC Department of Pediatrics

Divisions

Developmental Biology

Education

BS: Hangchou University, Hangchou, P.R. China, 1984.

MS: Shanghai Institute of Cell Biology, Academia Sinica, P.R. China, 1987.

PhD: Washington University, St. Louis, MO, 1995.

Fellowship: Postdoctoral Research Fellow, Howard Hughes Medical Institute/Harvard Medical School, Cambridge, MA, 1995-2000.

Publications

Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation. Zhao, B; Chen, Y; Jiang, N; Yang, L; Sun, S; Zhang, Y; Wen, Z; Ray, L; Liu, H; Hou, G; et al. Nature Communications. 2019; 10.

Tankyrase regulates apoptosis by activating JNK signaling in Drosophila. Feng, Y; Li, Z; Lv, L; Du, A; Lin, Z; Ye, X; Lin, Y; Lin, X. Biochemical and Biophysical Research Communications. 2018; 503:2234-2239.

Multiple roles of epithelial heparan sulfate in stomach morphogenesis. Huang, M; He, H; Belenkaya, T; Lin, X. Journal of Cell Science. 2018; 131.

EMC3 coordinates surfactant protein and lipid homeostasis required for respiration. Tang, X; Snowball, JM; Xu, Y; Na, C; Weaver, TE; Clair, G; Kyle, JE; Zink, EM; Ansong, C; Wei, W; et al. Journal of Clinical Investigation. 2017; 127:4314-4325.

Drosophila VAMP7 regulates Wingless intracellular trafficking. Gao, H; He, F; Lin, X; Wu, Y. PLoS ONE. 2017; 12:e0186938-e0186938.

Epithelial heparan sulfate regulates Sonic Hedgehog signaling in lung development. He, H; Huang, M; Sun, S; Wu, Y; Lin, X. PLoS Genetics. 2017; 13:e1006992-e1006992.

Wnt signaling promotes hindgut fate commitment through regulating multi-lineage genes during hESC differentiation. Zhang, X; Chen, Y; Ye, Y; Wang, J; Wang, H; Yuan, G; Lin, Z; Wu, Y; Zhang, Y; Lin, X. Cellular Signalling. 2017; 29:12-22.

sumoylation Stabilizes Smoothened to Promote Hedgehog Signaling. Qi, Y; Liu, H; Lin, X. Developmental Cell. 2016; 39:385-387.

Drosophila p24 and Sec22 regulate Wingless trafficking in the early secretory pathway. Li, X; Wu, Y; Shen, C; Belenkaya, TY; Ray, L; Lin, X. Biochemical and Biophysical Research Communications. 2015; 463:483-489.