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A photo of Cat Makarewich.

Assistant Professor, UC Department of Pediatrics

513-803-1591

Biography & Affiliation

Academic Affiliation

Assistant Professor, UC Department of Pediatrics

Departments

Heart, Molecular Cardiovascular Biology

Education

BA: University of Pennsylvania, Philadelphia, PA, 2005.

PhD: Temple University School of Medicine, Philadelphia, PA, 2014.

Fellowship: University of Texas Southwestern, Dallas, TX, 2019.

Publications

Selected Publication

The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy. Makarewich, CA; Munir, AZ; Schiattarella, GG; Bezprozvannaya, S; Raguimova, ON; Cho, EE; Vidal, AH; Robia, SL; Bassel-Duby, R; Olson, EN. eLife. 2018; 7.

MOXI Is a Mitochondrial Micropeptide That Enhances Fatty Acid β-Oxidation. Makarewich, CA; Baskin, KK; Munir, AZ; Bezprozvannaya, S; Sharma, G; Khemtong, C; Shah, AM; McAnally, JR; Malloy, CR; Szweda, LI; et al. Cell Reports. 2018; 23:3701-3709.

Mining for Micropeptides. Makarewich, CA; Olson, EN. Trends in Cell Biology. 2017; 27:685-696.

Widespread control of calcium signaling by a family of SERCA-inhibiting micropeptides. Anderson, DM; Makarewich, CA; Anderson, KM; Shelton, JM; Bezprozvannaya, S; Bassel-Duby, R; Olson, EN. Science Signaling. 2016; 9:ra119-ra119.

Muscle physiology: A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle. Nelson, BR; Makarewich, CA; Anderson, DM; Winders, BR; Troupes, CD; Wu, F; Reese, AL; McAnally, JR; Chen, X; Kavalali, ET; et al. Science. 2016; 351:271-275.

Newly Discovered Micropeptide Regulators of SERCA Form Oligomers but Bind to the Pump as Monomers. Singh, DR; Dalton, MP; Cho, EE; Pribadi, MP; Zak, TJ; Šeflová, J; Makarewich, CA; Olson, EN; Robia, SL. Journal of Molecular Biology. 2019; 431:4429-4443.

Prepare well and enjoy the journey. Makarewich, CA. Circulation Research. 2018; 123:1190-1191.

Coenzyme A–mediated degradation of pyruvate dehydrogenase kinase 4 promotes cardiac metabolic flexibility after high-fat feeding in mice. Schafer, C; Young, ZT; Makarewich, CA; Elnwasany, A; Kinter, C; Kinter, M; Szweda, LI. The Journal of biological chemistry. 2018; 293:6915-6924.

MED12 regulates a transcriptional network of calcium-handling genes in the heart. Baskin, KK; Makarewich, CA; DeLeon, SM; Ye, W; Chen, B; Beetz, N; Schrewe, H; Bassel-Duby, R; Olson, EN. JCI insight. 2017; 2.

Caveolae-localized L-type Ca2+ channels do not contribute to function or hypertrophic signalling in themouse heart. Correll, RN; Makarewich, CA; Zhang, H; Zhang, C; Sargent, MA; York, AJ; Berretta, RM; Chen, X; Houser, SR; Molkentin, JD. Cardiovascular Research. 2017; 113:749-759.