Halima Moncrieffe, PhD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-4676

Email halima.moncrieffe@cchmc.org

Juvenile idiopathic arthritis; inflammation; biomarkers; autoimmune disease; pharmacogenomics
Halima Moncrieffe, PhD, is an immunologist who has basic and translational research interests in mechanisms of autoimmune disease susceptibility and immunopathology. She studies how genetic and immunological variants contribute to inflammation and response to medication. Dr. Moncrieffe was selected as a TEDMED 2017 Research Scholar for her immunology expertise.
PhD: Imperial College London, London, United Kingdom.

View PubMed Publications

Moncrieffe H, Bennett MF, Tsoras M, Luyrink LK, Johnson AL, Xu H, Dare J, Becker ML, Prahalad S, Rosenkranz M, O'Neil KM, Nigrovic PA, Griffin TA, Lovell DJ, Grom AA, Medvedovic M, Thompson SD. Transcriptional profiles of JIA patient blood with subsequent poor response to methotrexate. Rheumatology (Oxford). 2017 Jun 3.

McIntosh L, Marion MC, Sudman M, Comeau ME, Prahalad S, Bohnsack JF, Haas JP, Wallace CA, Lovell DJ, Griffin TA, Becker ML, Nigrovic PA, Punaro M, Rosé CD, Wise CA, Boston Children’s JIA Registry, JIA gene expression studies, NIAMS JIA Genetic Registry, TREAT study, Understanding TNF Therapy in JIA Project, Moncrieffe H, Howard TD, Langefeld CD, Thompson SD. Genome-wide Association Reveals Novel Juvenile Idiopathic Arthritis Susceptibility Loci. Arthritis Rheumatol. 2017.

Clement CC, Moncrieffe H, Lele A, Janow HG, Becerra A, Bauli F, Saad FA, Perino G, Montagna C, Cobelli N, Hardin J, Stern LJ, Ilowite N, Porcelli SA, Santambrogio L. Autoimmune response to transthyretin in juvenile idiopathic arthritis. JCI Insight. 2016;1(2):e85633.

Botta Gordon-Smith S, Ursu S, Eaton S, Moncrieffe H, Wedderburn LR. Correlation of low CD73 expression on synovial lymphocytes with reduced adenosine generation and higher disease severity in juvenile idiopathic arthritis. Arthritis Rheumatol. 2015 Feb;67(2):545-54.

Moncrieffe H, et al. Addressing Healthcare Disparities in Autoimmune Disease: A Focus On Systemic Lupus Erythematosus in the USA. JPAS. 2015;7(9):64.

Moncrieffe H, Prahalad S, Thompson SD. Genetics of juvenile idiopathic arthritis: new tools bring new approaches. Curr Opin Rheumatol. 2014 Sep;26(5):579-84.

Moncrieffe H*, Cobb J*, Cule E*, Hinks A, et al (*joint first authors). Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases. Pharmacogenomics J. 2014 Aug;14(4):356-64.

Moncrieffe H, Ursu S, Holzinger D, Patrick F, Kassoumeri L, et al. A subgroup of juvenile idiopathic arthritis patients who respond well to methotrexate are identified by the serum biomarker MRP8/14 protein. Rheumatology (Oxford). 2013 Apr 25.

Holzinger D, Frosch, M, Kastrup, A, Otten, MH, Prince, FHM Suijlekom-Smit, LWA, ten Cate R, Hoppenreijs EPAH, Hansmann S, Moncrieffe H, Ursu S, Wedderburn L, Roth J, Foell D, Wittkowski H. The Toll-like receptor 4 agonist MRP8 and MRP14 protein complex is a sensitive indicator for disease activity and predicts relapses in Systemic-Onset Juvenile Idiopathic Arthritis. Ann Rheum Dis. 2012 Jun;71(6):974-80.

Moncrieffe H, Nistala K, Kamhieh Y, Evans J, Eddaoudi A, Eaton S, Wedderburn LR. High expression of the ectonucleotidase CD39 on T cells from the inflamed site identifies two distinct populations, one regulatory and one memory T cell population. J Immunol. 2010 Jul 1;185(1):134-43.