A photo of Halima Moncrieffe.

Assistant Professor, UC Department of Pediatrics

513-636-3338

About Me

Biography

Watch a video to learn more about Halima Moncrieffe, PhD, and her research.

Halima Moncrieffe, PhD, is an immunologist who has basic and translational research interests in mechanisms of autoimmune disease susceptibility and immunopathology. Dr. Moncrieffe studies how genetic and immunological variants contribute to inflammation and response to medication. The term 'idiopathic' in JIA denotes that there is no known cause for this debilitating disease. Dr. Moncrieffe's research helped reveal a putative immunological trigger for childhood arthritis and provides new insights into the complexities of JIA. Dr. Moncrieffe also identified a biomarker (MRP8/14) that is present in the blood of a subgroup of patients with JIA who are more likely to respond to methotrexate treatment. This work has translated from the research laboratory to patients and is available as a clinical test.

Dr. Moncrieffe has national and international leadership roles including as Chair of the Childhood Arthritis and Rheumatology Research Alliance (CARRA) SOP committee, and as an active member of the International Union of Immunological Societies' Clinical Immunology Committee. Dr. Moncrieffe leads workshops on research and leadership, and she is a regularly invited local and international speaker and panelist. Dr. Moncrieffe was selected as a TEDMED Research Scholar for her immunology expertise. Dr. Moncrieffe is an active mentor and her students have continued postgraduate studies, including at Ivy League institutions, to pursue their careers in research, medicine, nursing, and pharmacy.

Research Interests

Precision medicine; functional genomics; health disparities; pediatric autoimmune disease with specialty in juvenile idiopathic arthritis (JIA) and systemic lupus erythematosus (SLE)

Academic Affiliation

Assistant Professor, UC Department of Pediatrics

My Education

PhD: Imperial College London, London, United Kingdom.

My Publications

Moncrieffe H^, Ramsey L^, Sudman M, Smith C, Marion M, Langefeld C, Becker M, Thompson SD. Association of SLCO1B1*14 Allele with Poor Response to Methotrexate in Juvenile Idiopathic Arthritis Patients. ACR Open Rheumatology. 2019:1(1):58-62. (^Joint first authors.) 

Throm AT, Moncrieffe H, Orandi AB, Pingel JT, Geurs TL, Miller HL, Daugherty AL, Malkova ON, Lovell DJ, Thompson SD, Grom AA, Cooper MA, Oh ST, French AR. Identification of Enhanced Interferon-Gamma Signaling in Polyarticular Juvenile Idiopathic Arthritis with Mass Cytometry. JCI Insight. 2018;3(15):e121544. 

Ohl K, Nickel N, Moncrieffe H, Klemm P, Scheufen A, Föll D, Wixler V, Wedderburn L, Tenbrock K. The transcription factor CREM drives an inflammatory phenotype of T cells in Juvenile idiopathic arthritis. Pediatr Rheumatol Online J. 2018 Jun 20;16(1):39. 

Gohar F, Anink J, Moncrieffe H, Van Suijlekom-Smit LWA, Prince FHM, van Rossum MAJ, Dolman KM, Hoppenreijs EPAH, ten Cate R, Ursu S, Wedderburn LR, Horneff G, Frosch M, Foell D, and Holzinger D. S100A12 is associated with response to therapy in Juvenile Idiopathic Arthritis. J Rheumatol. 2018 Apr;45(4):547-554.

McIntosh L, Marion MC, Sudman M, Comeau ME, Prahalad S, Bohnsack JF, Haas JP, Wallace CA, Lovell DJ, Griffin TA, Becker ML, Nigrovic PA, Punaro M, Rosé CD, Wise CA, Boston Children’s JIA Registry, JIA gene expression studies, NIAMS JIA Genetic Registry, TREAT study, Understanding TNF Therapy in JIA Project, Moncrieffe H, Howard TD, Langefeld CD, Thompson SD. Genome-wide Association Reveals Novel Juvenile Idiopathic Arthritis Susceptibility Loci. Arthritis Rheumatol. 2017 Nov;69(11):2222-2232.

Moncrieffe H, Bennett MF, Tsoras M, Luyrink LK, Johnson AL, Xu H, Dare J, Becker ML, Prahalad S, Rosenkranz M, O’Neil KM, Nigrovic PA, Griffin TA, Lovell DJ, Grom AA, Medvedovic M, Thompson SD. Transcriptional profiles of JIA patient blood with subsequent poor response to methotrexate. Rheumatology (Oxford). 2017 Sep 1;56(9):1542-1551.

Clement CC, Moncrieffe H. Lele, A, Janow HG, Becerra A, Bauli F, Saad FA, Perino G, Montagna C, Cobelli N, Hardin J, Stern LJ, Ilowite N, Porcelli SA, Santambrogio L. Autoimmune response to transthyretin in juvenile idiopathic arthritis. JCI Insight. 2016 Feb;1(2).

Moncrieffe H, Tillery D, Mahaffey-Harris R. Addressing Healthcare Disparities in Autoimmune Disease: A Focus On Systemic Lupus Erythematosus in the USA. JPAS. 2015. 7(9):64.

Botta Gordon-Smith S, Ursu S, Eaton S, Moncrieffe H, Wedderburn LR. Correlation of low CD73 expression on synovial lymphocytes with reduced adenosine generation and higher disease severity in juvenile idiopathic arthritis. Arthritis Rheumatol. 2015 Feb;67(2):545-54.