Halima Moncrieffe, PhD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-3338

Email halima.moncrieffe@cchmc.org

Juvenile idiopathic arthritis; inflammation; biomarkers; autoimmune disease; pharmacogenomics
Halima Moncrieffe, PhD, is an immunologist who has basic and translational research interests in mechanisms of autoimmune disease susceptibility and immunopathology. She studies how genetic and immunological variants contribute to inflammation and response to medication. Dr. Moncrieffe was selected as a TEDMED 2017 Research Scholar for her immunology expertise.
PhD: Imperial College London, London, United Kingdom.

View Publications on ORCID

Throm AT, Moncrieffe H, Orandi AB, Pingel JT, Geurs TL, Miller HL, Daugherty AL, Malkova ON, Lovell DJ, Thompson SD, Grom AA, Cooper MA, Oh ST, French AR. Identification of Enhanced Interferon-Gamma Signaling in Polyarticular Juvenile Idiopathic Arthritis with Mass Cytometry. JCI Insight. 2018;3(15):e121544. 

Ohl K, Nickel N, Moncrieffe H, Klemm P, Scheufen A, Föll D, Wixler V, Wedderburn L, Tenbrock K. The transcription factor CREM drives an inflammatory phenotype of T cells in Juvenile idiopathic arthritis. Pediatr Rheumatol Online J. 2018 Jun 20;16(1):39. 

Gohar F, Anink J, Moncrieffe H, Van Suijlekom-Smit LWA, Prince FHM, van Rossum MAJ, Dolman KM, Hoppenreijs EPAH, ten Cate R, Ursu S, Wedderburn LR, Horneff G, Frosch M, Foell D, and Holzinger D. S100A12 is associated with response to therapy in Juvenile Idiopathic Arthritis. J Rheumatol. 2018 Jan 15. Epub ahead of print.

McIntosh L, Marion MC, Sudman M, Comeau ME, Prahalad S, Bohnsack JF, Haas JP, Wallace CA, Lovell DJ, Griffin TA, Becker ML, Nigrovic PA, Punaro M, Rosé CD, Wise CA, Boston Children’s JIA Registry, JIA gene expression studies, NIAMS JIA Genetic Registry, TREAT study, Understanding TNF Therapy in JIA Project, Moncrieffe H, Howard TD, Langefeld CD, Thompson SD. Genome-wide Association Reveals Novel Juvenile Idiopathic Arthritis Susceptibility Loci. Arthritis Rheumatol. 2017 Nov;69(11):2222-2232.

Moncrieffe H, Bennett MF, Tsoras M, Luyrink LK, Johnson AL, Xu H, Dare J, Becker ML, Prahalad S, Rosenkranz M, O’Neil KM, Nigrovic PA, Griffin TA, Lovell DJ, Grom AA, Medvedovic M, Thompson SD. Transcriptional profiles of JIA patient blood with subsequent poor response to methotrexate. Rheumatology (Oxford). 2017 Sep 1;56(9):1542-1551.

Clement CC, Moncrieffe H. Lele, A, Janow HG, Becerra A, Bauli F, Saad FA, Perino G, Montagna C, Cobelli N, Hardin J, Stern LJ, Ilowite N, Porcelli SA, Santambrogio L. Autoimmune response to transthyretin in juvenile idiopathic arthritis. JCI Insight. 2016 Feb;1(2).

Moncrieffe H, Tillery D, Mahaffey-Harris R. Addressing Healthcare Disparities in Autoimmune Disease: A Focus On Systemic Lupus Erythematosus in the USA. JPAS. 2015. 7(9):64.

Botta Gordon-Smith S, Ursu S, Eaton S, Moncrieffe H, Wedderburn LR. Correlation of low CD73 expression on synovial lymphocytes with reduced adenosine generation and higher disease severity in juvenile idiopathic arthritis. Arthritis Rheumatol. 2015 Feb;67(2):545-54.

Moncrieffe H, Prahalad S, Thompson SD. Genetics of juvenile idiopathic arthritis: new tools bring new approaches. Curr Opin Rheumatol. 2014 Sep;26(5):579-84.

Moncrieffe H*, Cobb J*, Cule E*, Hinks A, Ursu S, Patrick F, Kassoumemri L, Flynn E, Bulatović M, Wulffraat N, van Zelst B, de Jonge R, Bohm M, Dolezalova P, Hirani S, Newman S, Whitworth P, Southwood TR, De Iorio M; Childhood Arthritis Response to Medication Study (CHARMS); Childhood Arthritis Prospective Study (CAPS); BSPAR study group, Wedderburn LR, Thomson W (*joint first authors). Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases. Pharmacogenomics J. 2014 Aug;14(4):356-64.