Kana Mizuno, PhD

Interferon-induced cell senescence as a novel mechanism of eculizumab resistance in transplant associated thrombotic microangiopathy. Webster, A; Mizuno, K; Luebbering, N; Davies, SM; Jodele, S; Sabulski, A. Blood. 2025; 146(Supplement 1):509.

Precision Alemtuzumab Dosing Results in Day 0 Target Range Achievement in 80% of IEI Patients and Minimizes Risks of GVHD, Clinically Significant Mixed Chimerism, and Secondary Graft Failure. Marsh, R; Khoury, R; Mizuno, K; Hosawi, A; Cottrell, C; Nguyen, E; Landon, B; Chandra, S; Jordan, M; Kumar, A; Bleesing, J; Davies, S; Moore, C; Mehta, P. Journal of Human Immunity. 2025; 1(CIS2025).

Phase 1 study of quercetin, a natural antioxidant for children and young adults with Fanconi anemia. Mehta, PA; Nelson, A; Loveless, S; Lane, A; Fukuda, T; Teusink-Cross, A; Elder, D; Lagory, D; Miller, E; Cancelas, JA; Edwards, S; Chihanga, T; Wells, SI; Davies, SM. Blood advances. 2025; 9(8):1927-1939.

Unraveling the Challenges of Non-Responders to the Eculizumab Treatment with High-Risk Hematopoietic Stem Cell Transplant-Associated Thrombotic Microangiopathy (TA-TMA) Mizuno, K; Teusink-Cross, A; Sabulski, A; Davies, SM; Jodele, S. Transplantation and Cellular Therapy. 2025; 31(2):s542-s543.

A prospective multi-institutional study of eculizumab to treat high-risk stem cell transplantation-associated TMA. Jodele, S; Dandoy, CE; Aguayo-Hiraldo, P; Lane, A; Teusink-Cross, A; Sabulski, A; Mizuno, K; Laskin, BL; Freedman, J; Davies, SM. Blood. 2024; 143(12):1112-1123.

Adopting Model-Informed Precision-Dosing for Eculizumab in Transplant Associated-Thrombotic Microangiopathy to Gene Therapies. Jodele, S; Mizuno, K; Sabulski, A; Vinks, AA. Clinical Pharmacology and Therapeutics. 2023; 114(3):511-514.

Model-Informed Precision Dosing Guidance of Ethosuximide Developed from a Randomized Controlled Clinical Trial of Childhood Absence Epilepsy. Mizuno, K; Capparelli, EV; Fukuda, T; Dong, M; Adamson, PC; Blumer, JL; Cnaan, A; Clark, PO; Reed, MD; Shinnar, S; Vinks, AA; Glauser, TA. Clinical Pharmacology and Therapeutics. 2023; 114(2):459-469.

Low-dose Dasatinib Ameliorates Hypertrophic Cardiomyopathy in Noonan Syndrome with Multiple Lentigines. Yi, J-S; Perla, S; Huang, Y; Mizuno, K; Giordano, FJ; Vinks, AA; Bennett, AM. Cardiovascular Drugs and Therapy. 2022; 36(4):589-604.

Eculizumab precision-dosing algorithm for thrombotic microangiopathy in children and young adults undergoing HSCT. Mizuno, K; Dandoy, CE; Teusink-Cross, A; Davies, SM; Vinks, AA; Jodele, S. Blood advances. 2022; 6(5):1454-1463.

187 Eculizumab Precision Dosing Algorithm for TA-TMA in Children and Young Adults Undergoing Stem Cell Transplant. Mizuno, K; Dandoy, CE; Teusink-Cross, A; Davies, SM; Vinks, A; Jodele, S. Transplantation and Cellular Therapy. 2022; 28(3):s154-s155.