Lisa J. Martin, PhD

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-1244

Fax 513-636-7509

Email lisa.martin@cchmc.org

Statistical genetics; genetics of heart malformations; pharmacogenetics; genetics of allergic disorders
The future of genetics and genomics demands purposeful collaborative science and its translation to improving clinical care. Dr. Martin is an internationally recognized statistical geneticist with the goal of leveraging genetic and genomic data to transform the care of children. Throughout Dr. Martin’s career, she has connected researchers and clinicians to genetics and genomics, resulting in 180 peer reviewed publications and a strong record of collaborative grant funding. A major focus of her work is understanding how genes act in context. For most conditions that she studies (such as heart defects and asthma), a single gene does not explain outcomes. Rather, genes are important in a larger context. That context may be environmental factors or other genes. Her work has identified novel gene by gene and gene by environment interactions. Importantly, by incorporating interactions, subgroups of individuals have been identified. Further, to really understand how genes relate to outcomes, it is important to measure the outcomes well. Thus, another part of Dr. Martin’s work is improving descriptions of outcomes, whether it is patient reports on how they feel or characterizing biologic changes. By refining how outcomes are measured, she expects to gain important clinical insight on how individuals have improve health outcomes. Her connection of researchers and clinicians to genetics and genomics extends beyond research as she is a highly committed teacher and mentor. She works directly with the training programs offered through the Division of Human Genetics (Master’s in Genetic Counseling, Residency and Fellowship in Medical Genetics) as well as through the Department of Molecular Genetics (PhD).

PhD: (with Honors) University of Kansas, Lawrence, KS, 1999.

Post-doctoral fellow: Southwest Foundation for Biomedical Research, San Antonio, TX, 2002.

View PubMed Publications

Liu X, Yagi H, Saeed S, Bais AS, Gabriel GC, Chen Z, Peterson KA, Li Y, Schwartz MC, Reynolds WT, Saydmohammed M, Gibbs B, Wu Y, Devine W, Chatterjee B, Klena NT, Kostka D, de Mesy Bentley KL, Ganapathiraju MK, Dexheimer P, Leatherbury L, Khalifa O, Bhagat A, Zahid M, Pu W, Watkins S, Grossfeld P, Murray SA, Porter GA Jr, Tsang M, Martin LJ*, Woodrow Benson D, Aronow BJ, Lo CW. The complex genetics of hypoplastic left heart syndrome. Nat Genet. 2017 Jul;49(7):1152-1159.

Collins MH, Martin LJ*, Alexander ES, Boyd JT, Sheridan R, He H, Pentiuk S, Putnam PE, Abonia JP, Mukkada VA, Franciosi JP, Rothenberg ME. Newly developed and validated eosinophilic esophagitis histology scoring system and evidence that it outperforms peak eosinophil count for disease diagnosis and monitoring. Dis Esophagus. 2017;30(3):1-8.

Martin LJ, Franciosi JP, Collins MH, Abonia JP, Lee JJ, Hommel KA, Varni JW, Grotjan JT, Eby M, He H, Marsolo K, Putnam PE, Garza JM, Kaul A, Wen T, Rothenberg ME. Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS® v2.0) identify histologic and molecular correlates of the key clinical features of disease. J Allergy Clin Immunol. 2015;135(6):1519-1528.

LeMasters GK, Khurana Hershey GK, Sivaprasad U, Martin LJ*, Pilipenko V, Ericksen MB, Burkle JW, Lindsey MA, Bernstein DI, Lockey JE, Gareri J, Lubetsky A, Koren G, Biagini Myers JM. N-acetyltransferase 1 polymorphism increases cotinine levels in Caucasian children exposed to secondhand smoke: the CCAAPS birth cohort. Pharmacogenomics J. 2015 Apr;15(2):189-95.

Alexander ES, Martin LJ*, Collins MH, Kottyan LC, Sucharew H, He H, Mukkada VA, Succop PA, Abonia JP, Foote H, Eby MD, Grotjan TM, Greenler AJ, Dellon ES, Demain JG, Furuta GT, Gurian LE, Harley JB, Hopp RJ, Kagalwalla A, Kaul A, Nadeau KC, Noel RJ, Putnam PE, von Tiehl KF, Rothenberg ME. Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of eosinophilic esophagitis. J Allergy Clin Immunol. 2014;134(5):1084-1092.

Martin LJ*, Pilipenko V, Kaufman KM, Cripe L, Kottyan LC, Keddache M, Dexheimer P, Weirauch MT, Benson DW. Whole Exome Sequencing for Familial Bicuspid Aortic Valve Identifies Putative Variants. Circ Cardiovascular Genetics. 2014;7:677-683. 

Sadhasivam S,  Chidambaran C, Ngamprasertwong P, Esslinger HR, Prows C, Zhang X, Martin LJ, McAuliffe J. Race and unequal burden of perioperative pain and opioid related adverse effects in children. Pediatrics. 2012 May;129(5):832-8.

Martin LJ, Gupta J, Jyothula SSSK, Butsch Kovacic M, Biagini Myers JM, Patterson TL, Ericksen MB, He H, Gibson AM, Baye TM, Amirisetty S, Tsoras AM, Sha Y, Eissa NT, Hershey GK.  Functional variant in the autophagy-related 5 gene promoter is associated with childhood asthma. PLoS One. 2012;7(4):e33454.

Rothenberg ME, Spergel JM, Sherrill JD, Annaiah K, Martin LJ, Cianferoni A, Gober L, Kim C, Glessner J, Frackelton E, Thomas K, Blanchard C, Liacouras C, Verma R, Aceves S, Collins MH, Brown-Whitehorn T, Putnam PE, Franciosi JP, Chiavacci RM, Grant SF, Abonia JP, Sleiman PM, Hakonarson H. Common variants at 5q22 associate with pediatric eosinophilic esophagitis. Nat Genet. 2010 Apr;42(4):289-91.

Martin LJ, Ramachandran V, Cripe LH, Hinton RB, Andelfinger G, Tabangin M, Shooner K, Keddache M, Benson DW. Evidence in Favor of Linkage to Human Chromosomal Regions 18q, 5q and 13q for Bicuspid Aortic Valve and Associated Cardiovascular Malformations.  Hum Gen. 2007 Apr;121(2):275-84.