A photo of Lisa Martin.

Professor, UC Department of Pediatrics

513-636-1244

513-636-7509

Biography & Affiliation

Biography

The future of genetics and genomics demands purposeful collaborative science and its translation to improving clinical care. Dr. Martin is an internationally recognized statistical geneticist with the goal of leveraging genetic and genomic data to transform the care of children. Throughout Dr. Martin’s career, she has connected researchers and clinicians to genetics and genomics, resulting in 196 peer reviewed publications and a strong record of collaborative grant funding. A major focus of her work is understanding how genes act in context. For most conditions that she studies (such as heart defects and asthma), a single gene does not explain outcomes. Rather, genes are important in a larger context. That context may be environmental factors or other genes. Her work has identified novel gene by gene and gene by environment interactions. Importantly, by incorporating interactions, subgroups of individuals have been identified. Further, to really understand how genes relate to outcomes, it is important to measure the outcomes well. Thus, another part of Dr. Martin’s work is improving descriptions of outcomes, whether it is patient reports on how they feel or characterizing biologic changes. By refining how outcomes are measured, she expects to gain important clinical insight on how individuals have improve health outcomes. Her connection of researchers and clinicians to genetics and genomics extends beyond research as she is a highly committed teacher and mentor. She works directly with the training programs offered through the Division of Human Genetics (Master’s in Genetic Counseling, Residency and Fellowship in Medical Genetics) as well as through the Department of Molecular Genetics (PhD).

Research Interests

Statistical genetics; genetics of heart malformations; pharmacogenetics; genetics of allergic disorders

Academic Affiliation

Professor, UC Department of Pediatrics

Departments

Human Genetics, Biostatistics

Education

BA: University of Kansas, Lawrence, KS, 1991.

MA: University of Kansas, Lawrence, KS, 1993. 

PhD: (with Honors) University of Kansas, Lawrence, KS, 1999.

Post-doctoral fellow: Southwest Foundation for Biomedical Research, San Antonio, TX, 2002.

Publications

Selected Publication

Pharmacogenetics of Sertraline Tolerability and Response in Pediatric Anxiety and Depressive Disorders. Poweleit, EA; Aldrich, SL; Martin, LJ; Hahn, D; Strawn, JR; Ramsey, LB. Journal of Child and Adolescent Psychopharmacology. 2019; 29:348-361.

Genetic Influences on Behavioral Outcomes After Childhood TBI: A Novel Systems Biology-Informed Approach. Kurowski, BG; Treble-Barna, A; Pilipenko, V; Wade, SL; Yeates, KO; Taylor, HG; Martin, LJ; Jegga, AG. Frontiers in Genetics. 2019; 10.

A Pediatric Asthma Risk Score to better predict asthma development in young children. Myers, JM B; Schauberger, E; He, H; Martin, LJ; Kroner, J; Hill, GM; Ryan, PH; LeMasters, GK; Bernstein, DI; Lockey, JE; et al. Journal of Allergy and Clinical Immunology. 2019; 143:1803-1810.e2.

Role of Segregation for Variant Discovery in Multiplex Families Ascertained by Probands With Left Sided Cardiovascular Malformations. Martin, LJ; Pilipenko, V; Benson, DW. Frontiers in Genetics. 2019; 9.

Eosinophilic esophagitis (EoE) genetic susceptibility is mediated by synergistic interactions between EoE-specific and general atopic disease loci. Martin, LJ; He, H; Collins, MH; Abonia, JP; Myers, JM B; Eby, M; Johansson, H; Kottyan, LC; Hershey, GK K; Rothenberg, ME. Journal of Allergy and Clinical Immunology. 2018; 141:1690-1698.

KIF3A genetic variation is associated with pediatric asthma in the presence of eczema independent of allergic rhinitis. Johansson, E; Myers, JM B; Martin, LJ; He, H; Pilipenko, V; Mersha, T; Weirauch, M; Salomonis, N; Ryan, P; LeMasters, GK; et al. Journal of Allergy and Clinical Immunology. 2017; 140:595-598.e5.

Applying Systems Biology Methodology To Identify Genetic Factors Possibly Associated with Recovery after Traumatic Brain Injury. Kurowski, BG; Treble-Barna, A; Pitzer, AJ; Wade, SL; Martin, LJ; Chima, RS; Jegga, A. Journal of Neurotrauma. 2017; 34:2280-2290.

The complex genetics of hypoplastic left heart syndrome. Liu, X; Yagi, H; Saeed, S; Bais, AS; Gabriel, GC; Chen, Z; Peterson, KA; Li, Y; Schwartz, MC; Reynolds, WT; et al. Nature Genetics. 2017; 49:1152-1159.

Influence of Dopamine-Related Genes on Neurobehavioral Recovery after Traumatic Brain Injury during Early Childhood. Treble-Barna, A; Wade, SL; Martin, LJ; Pilipenko, V; Yeates, KO; Taylor, HG; Kurowski, BG. Journal of Neurotrauma. 2017; 34:1919-1931.

Pharmacogenetics of Antiepileptic Drug Efficacy in Childhood Absence Epilepsy. Glauser, TA; Holland, K; O'Brien, VP; Keddache, M; Martin, LJ; Clark, PO; Cnaan, A; Dlugos, D; Hirtz, DG; Shinnar, S; et al. Annals of Neurology. 2017; 81:444-453.