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Mary Kate Manhard, PhD

  • Assistant Professor, UC Department of Radiology

About

Biography

My research interests include developing new acquisition and reconstruction techniques for magnetic resonance imaging (MRI). Specifically, I focus on quantitative imaging and accelerated imaging, with applications in musculoskeletal (MSK) and brain MRI.

Obtaining an MRI is a slow process. It can be difficult for patients to lie still, especially young children. It can also be an uncomfortable and anxiety-producing experience for some patients. I look at ways to accelerate MRI acquisitions and efficiently encode data to collect multiple image contrasts very quickly. MRI contrast is relative, and I work on using quantitative imaging so that images are robust and repeatable. With these techniques, I’m interested in translatable research resulting in robust methods that can be applied in the clinic, directly improving the care and outcomes for patients.

I am a member of the International Society of Magnetic Resonance in Medicine and received the National Institutes of Health (NIH) F32 Ruth L. Kirschstein Postdoctoral Fellowship Award (2018-2020). I have been a researcher for nearly ten years, and I began my work at Cincinnati Children’s in 2020.

BS: Electrical Engineering, Clemson University, Clemson, SC.

MS, PhD: Biomedical Engineering, Vanderbilt University, Nashville, TN.

Postdoc: A. A. Martinos Center for Biomedical Imaging, Mass General Hospital, Harvard Medical School, Boston, MA.

Services and Specialties

Radiology and Medical Imaging

Interests

Neuroimaging; MSK imaging; quantitative MRI; accelerated imaging

Research Areas

Radiology, Imaging

Publications

Liver T1 Relaxation Quantification Using a 3-Dimensional Interleaved Look-Locker Acquisition With T2 Preparation Pulse Sequence (3D-QALAS): Comparison With Conventional 2-Dimensional MOLLI. Gandhi, DB; Pednekar, A; Wang, H; Tkach, JA; Dudley, JA; Manhard, MK; Trout, AT; Dillman, JR. Journal of Computer Assisted Tomography. 2022.

Change in T2* measurements of placenta and fetal organs during Braxton Hicks contractions. Abaci Turk, E; Stout, JN; Feldman, HA; Gagoski, B; Zhou, C; Tamen, R; Manhard, MK; Adalsteinsson, E; Roberts, DJ; Golland, P; et al. Placenta. 2022; 128:69-71.

Heterogeneity of Tau Deposition and Microvascular Involvement in MCI and AD. Bryant, AG; Manhard, MK; Salat, DH; Rosen, BR; Hyman, BT; Johnson, KA; Huang, S; Bennett, RE; Yen, YF. Current Alzheimer Research. 2021; 18:711-720.

Distortion-free, high-isotropic-resolution diffusion MRI with gSlider BUDA-EPI and multicoil dynamic B0 shimming. Liao, C; Bilgic, B; Tian, Q; Stockmann, JP; Cao, X; Fan, Q; Iyer, SS; Wang, F; Ngamsombat, C; Lo, WC; et al. Magnetic Resonance in Medicine. 2021; 86:791-803.

A multi-inversion multi-echo spin and gradient echo echo planar imaging sequence with low image distortion for rapid quantitative parameter mapping and synthetic image contrasts. Manhard, MK; Stockmann, J; Liao, C; Park, D; Han, S; Fair, M; van den Boomen, M; Polimeni, J; Bilgic, B; Setsompop, K. Magnetic Resonance in Medicine. 2021; 86:866-880.

Diffusion-PEPTIDE: Distortion- and blurring-free diffusion imaging with self-navigated motion-correction and relaxometry capabilities. Fair, MJ; Liao, C; Manhard, MK; Setsompop, K. Magnetic Resonance in Medicine. 2021; 85:2417-2433.

Accelerated spin-echo functional MRI using multisection excitation by simultaneous spin-echo interleaving (MESSI) with complex-encoded generalized slice dithered enhanced resolution (cgSlider) simultaneous multislice echo-planar imaging. Han, S; Liao, C; Manhard, MK; Park, DJ; Bilgic, B; Fair, MJ; Wang, F; Blazejewska, AI; Grissom, WA; Polimeni, JR; et al. Magnetic Resonance in Medicine. 2020; 84:206-220.

Blood Oxygen Level-Dependent MRI of the Myocardium with Multiecho Gradient-Echo Spin-Echo Imaging. van den Boomen, M; Manhard, MK; Snel, GJ H; Han, S; Emblem, KE; Slart, RH J A; Sosnovik, DE; Catana, C; Rosen, BR; Prakken, NH J; et al. Radiology. 2020; 294:538-545.

High-fidelity, high-isotropic-resolution diffusion imaging through gSlider acquisition with B1+ and T1 corrections and integrated ΔB0 /Rx shim array. Liao, C; Stockmann, J; Tian, Q; Bilgic, B; Arango, NS; Manhard, MK; Huang, SY; Grissom, WA; Wald, LL; Setsompop, K. Magnetic Resonance in Medicine. 2020; 83:56-67.

Highly accelerated multishot echo planar imaging through synergistic machine learning and joint reconstruction. Bilgic, B; Chatnuntawech, I; Manhard, MK; Tian, Q; Liao, C; Iyer, SS; Cauley, SF; Huang, SY; Polimeni, JR; Wald, LL; et al. Magnetic Resonance in Medicine. 2019; 82:1343-1358.