A photo of Ruhikanta Meetei.

Member, Division of Experimental Hematology & Cancer Biology

Associate Professor, UC Department of Pediatrics

513-636-1768

513-636-3768

Biography & Affiliation

Clinical Interests

Fanconi anemia; chromosome instability; DNA repair; multiprotein complex

Research Interests

Functional analysis of Fanconi anemia gene products; identification of new FA genes and signal transduction pathways that regulate DNA damage induced activation of the FA-core complex; biochemical purification of multiprotein complexes from human cell extracts, immunoprecipitation, RNAi, and biochemical assays; Fanconi anemia as a model system to study some of the important fundamental questions of cancer biology in general.

Academic Affiliation

Associate Professor, UC Department of Pediatrics

Divisions

Experimental Hematology and Cancer Biology, Cancer and Blood Diseases

Education

BS: Manipur University, India, 1989.

MS: Manipur University, India, 1992.

PhD: Indian Institute of Science, Bangalore, India, 2000.

Publications

Fancd2-deficient hematopoietic stem and progenitor cells depend on augmented mitochondrial translation for survival and proliferation. Chatla, S; Du, W; Wilson, AF; Meetei, AR; Pang, Q. Stem Cell Research. 2019; 40:101550-101550.

The nuclear DEK interactome supports multi-functionality. Smith, EA; Krumpelbeck, EF; Jegga, AG; Prell, M; Matrka, MM; Kappes, F; Greis, KD; Ali, AM; Meetei, AR; Wells, SI. Proteins: Structure, Function, and Bioinformatics. 2018; 86:88-97.

Coordination of the recruitment of the FANCD2 and PALB2 Fanconi anemia proteins by an ubiquitin signaling network. Bick, G; Zhang, F; Meetei, AR; Andreassen, PR. Chromosoma: biology of the nucleus. 2017; 126:417-430.

Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang, T; Du, W; Wilson, AF; Namekawa, SH; Andreassen, PR; Meetei, AR; Pang, Q. Scientific Reports. 2017; 7.

DEK is required for homologous recombination repair of DNA breaks. Smith, EA; Gole, B; Willis, NA; Soria, R; Starnes, LM; Krumpelbeck, EF; Jegga, AG; Ali, AM; Guo, H; Meetei, AR; et al. Scientific Reports. 2017; 7.

Instructive Role of MLL-Fusion Proteins Revealed by a Model of t(4;11) Pro-B Acute Lymphoblastic Leukemia. Lin, S; Luo, RT; Ptasinska, A; Kerry, J; Assi, SA; Wunderlich, M; Imamura, T; Kaberlein, JJ; Rayes, A; Althoff, MJ; et al. Cancer Cell. 2016; 30:737-749.

Fancb deficiency impairs hematopoietic stem cell function. Du, W; Amarachintha, S; Erden, O; Wilson, A; Meetei, AR; Andreassen, PR; Namekawa, SH; Pang, Q. Scientific Reports. 2015; 5.

Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling. Varney, ME; Niederkorn, M; Konno, H; Matsumura, T; Gohda, J; Yoshida, N; Akiyama, T; Christie, S; Fang, J; Miller, D; et al. The Journal of Experimental Medicine. 2015; 212:1967-1985.

FANCB is essential in the male germline and regulates H3K9 methylation on the sex chromosomes during meiosis. Kato, Y; Alavattam, KG; Sin, H; Meetei, AR; Pang, Q; Andreassen, PR; Namekawa, SH. Human Molecular Genetics. 2015; 24:5234-5249.