A photo of Ruhikanta Meetei.

Ruhikanta A. Meetei, PhD


  • Member, Division of Experimental Hematology & Cancer Biology
  • Associate Professor, UC Department of Pediatrics

About

Biography

I have been a researcher for more than 25 years and began working at Cincinnati Children’s in 2004. My research interests include Fanconi anemia (FA), Bloom syndrome (BLM) and cancer.

I'm working to uncover the molecular mechanism of both FA and BLM. My research discovered three new FA genes and BLM binding proteins, including FANCB, FANCL and FANCM. I have expertise in FA, chromosome instability, DNA repair and multiprotein complexes.

Our study of FA involves the functional analysis of identified gene products as well as the identification of new FA genes and pathways of signal transduction that regulate DNA damage-induced activation of the core complex of FA. FA provides a model system for studying some of the critical questions fundamental to understanding cancer's general biology. Our lab employs biochemical purification of multiprotein complexes extracted from human cells, ribonucleic acid interference (RNAi), gene KO by Crispr-Cas9 system immunoprecipitations and biochemical assays.

I received the ASH Scholar Award from the American Society of Hematology and my research has been funded by federal grants. My work has been published in many respected journals, such as Nature Genetics, Molecular Cell, Genes & Development, Proteins: Structure, Function, and Bioinformatics, Reproduction, Stem Cell Research, Chromosoma: Biology of the Nucleus, Scientific Reports, Cancer Cell, The Journal of Experimental Medicine and Human Molecular Genetics.

Publications

FANCD2 is required for the repression of germline transposable elements. Nie, Y; Wilson, AF; DeFalco, T; Meetei, AR; Namekawa, SH; Pang, Q. Reviews of Reproduction. 2020; 159:659-668.

Fancd2-deficient hematopoietic stem and progenitor cells depend on augmented mitochondrial translation for survival and proliferation. Chatla, S; Du, W; Wilson, AF; Meetei, AR; Pang, Q. Stem Cell Research. 2019; 40.

The nuclear DEK interactome supports multi-functionality. Smith, EA; Krumpelbeck, EF; Jegga, AG; Prell, M; Matrka, MM; Kappes, F; Greis, KD; Ali, AM; Meetei, AR; Wells, SI. Proteins: Structure, Function and Genetics. 2018; 86:88-97.