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Member, Division of Experimental Hematology & Cancer Biology
Associate Professor, UC Department of Pediatrics
Fanconi anemia; chromosome instability; DNA repair; multiprotein complex
Functional analysis of Fanconi anemia gene products; identification of new FA genes and signal transduction pathways that regulate DNA damage induced activation of the FA-core complex; biochemical purification of multiprotein complexes from human cell extracts, immunoprecipitation, RNAi, and biochemical assays; Fanconi anemia as a model system to study some of the important fundamental questions of cancer biology in general.
Experimental Hematology and Cancer Biology, Cancer and Blood Diseases
BS: Manipur University, India, 1989.
MS: Manipur University, India, 1992.
PhD: Indian Institute of Science, Bangalore, India, 2000.
Fancd2-deficient hematopoietic stem and progenitor cells depend on augmented mitochondrial translation for survival and proliferation.
Chatla, S; Du, W; Wilson, AF; Meetei, AR; Pang, Q.
Stem Cell Research.
The nuclear DEK interactome supports multi-functionality.
Smith, EA; Krumpelbeck, EF; Jegga, AG; Prell, M; Matrka, MM; Kappes, F; Greis, KD; Ali, AM; Meetei, AR; Wells, SI.
Proteins: Structure, Function, and Bioinformatics.
Coordination of the recruitment of the FANCD2 and PALB2 Fanconi anemia proteins by an ubiquitin signaling network.
Bick, G; Zhang, F; Meetei, AR; Andreassen, PR.
Chromosoma: biology of the nucleus.
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
Zhang, T; Du, W; Wilson, AF; Namekawa, SH; Andreassen, PR; Meetei, AR; Pang, Q.
DEK is required for homologous recombination repair of DNA breaks.
Smith, EA; Gole, B; Willis, NA; Soria, R; Starnes, LM; Krumpelbeck, EF; Jegga, AG; Ali, AM; Guo, H; Meetei, AR; et al.
Instructive Role of MLL-Fusion Proteins Revealed by a Model of t(4;11) Pro-B Acute Lymphoblastic Leukemia.
Lin, S; Luo, RT; Ptasinska, A; Kerry, J; Assi, SA; Wunderlich, M; Imamura, T; Kaberlein, JJ; Rayes, A; Althoff, MJ; et al.
Fancb deficiency impairs hematopoietic stem cell function.
Du, W; Amarachintha, S; Erden, O; Wilson, A; Meetei, AR; Andreassen, PR; Namekawa, SH; Pang, Q.
Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling.
Varney, ME; Niederkorn, M; Konno, H; Matsumura, T; Gohda, J; Yoshida, N; Akiyama, T; Christie, S; Fang, J; Miller, D; et al.
The Journal of Experimental Medicine.
FANCB is essential in the male germline and regulates H3K9 methylation on the sex chromosomes during meiosis.
Kato, Y; Alavattam, KG; Sin, H; Meetei, AR; Pang, Q; Andreassen, PR; Namekawa, SH.
Human Molecular Genetics.
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