Satish K. Madala, PhD

Biography & Affiliation Education Publications

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Associate Professor, UC Department of Pediatrics

Biography & Affiliation

Biography

Dr. Satish K. Madala joined the Division of Pulmonary Medicine in 2011, after postdoctoral training in fibrotic disease research in the laboratory of Dr. Thomas A. Wynn, NIAID, NIH. Dr. Madala’s major research interests are to identify cellular and molecular mechanisms of human fibrotic lung diseases in particular idiopathic pulmonary fibrosis, cystic fibrosis, asthma and scleroderma. We use transgenic and non-transgenic mouse models to determine the molecular pathways that dictate pulmonary inflammation and fibrosis.

Academic Affiliation

Associate Professor, UC Department of Pediatrics

Departments

Pulmonary Medicine, Fibrosis

Education

Postdoctoral training: Wynn Lab, Immunopathogenesis Section, LPD, NIAD, NIH, Bethesda, MD.

PhD: National Institute of Nutrition, Osmania University, Hyderabad, India.

Publications

Selected Publication

Wilms' tumor 1 drives fibroproliferation and myofibroblast transformation in severe fibrotic lung disease. Sontake, V; Kasam, RK; Sinner, D; Korfhagen, TR; Reddy, GB; White, ES; Jegga, AG; Madala, SK. JCI insight. 2018; 3.

Unsupervised gene expression analyses identify IPF-severity correlated signatures, associated genes and biomarkers. Wang, Y; Yella, J; Chen, J; McCormack, FX; Madala, SK; Jegga, AG. BMC Pulmonary Medicine. 2017; 17.

Repetitive intradermal bleomycin injections evoke T-helper cell 2 cytokine-driven pulmonary fibrosis. Singh, B; Kasam, RK; Sontake, V; Wynn, TA; Madala, SK. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2017; 313:L796-L806.

Hsp90 regulation of fibroblast activation in pulmonary fibrosis. Sontake, V; Wang, Y; Kasam, RK; Sinner, D; Reddy, GB; Naren, AP; McCormack, FX; White, ES; Jegga, AG; Madala, SK. JCI insight. 2017; 2.

Unique and Redundant Functions of p70 Ribosomal S6 Kinase Isoforms Regulate Mesenchymal Cell Proliferation and Migration in Pulmonary Fibrosis. Madala, SK; Sontake, V; Edukulla, R; Davidson, CR; Schmidt, S; Hardie, WD. American Journal of Respiratory Cell and Molecular Biology. 2016; 55:792-803.

IL-31-Driven Skin Remodeling Involves Epidermal Cell Proliferation and Thickening That Lead to Impaired Skin-Barrier Function. Singh, B; Jegga, AG; Shanmukhappa, KS; Edukulla, R; Khurana, GH; Medvedovic, M; Dillon, SR; Madala, SK. PLoS ONE. 2016; 11:e0161877-e0161877.

Fibrocytes Regulate Wilms Tumor 1-Positive Cell Accumulation in Severe Fibrotic Lung Disease. Sontake, V; Shanmukhappa, SK; DiPasquale, BA; Reddy, GB; Medvedovic, M; Hardie, WD; White, ES; Madala, SK. Journal of immunology (Baltimore, Md. : 1950). 2015; 195:3978-3991.

Th2 Cytokines Augment IL-31/IL-31RA Interactions via STAT6-dependent IL-31RA Expression. Edukulla, R; Singh, B; Jegga, AG; Sontake, V; Dillon, SR; Madala, SK. The Journal of biological chemistry. 2015; 290:13510-13520.

Bone Marrow-Derived Stromal Cells Are Invasive and Hyperproliferative and Alter Transforming Growth Factor-alpha-Induced Pulmonary Fibrosis. Madala, SK; Edukulla, R; Schmidt, S; Davidson, C; Ikegami, M; Hardie, WD. American Journal of Respiratory Cell and Molecular Biology. 2014; 50:777-786.

Dual Targeting of MEK and PI3K Pathways Attenuates Established and Progressive Pulmonary Fibrosis. Madala, SK; Edukulla, R; Phatak, M; Schmidt, S; Davidson, C; Acciani, TH; Korfhagen, TR; Medvedovic, M; LeCras, TD; Wagner, K; et al. PLoS ONE. 2014; 9:e86536-e86536.