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Satish K. Madala, PhD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-9852

Email satish.madala@cchmc.org

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Research Interests

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Biography

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Dr. Madala’s research interests are to identify the cellular and molecular mechanisms involved the initiation, maintenance, and progression of pulmonary fibrosis. His lab’s research tools include using molecular, biochemical and immunology methods to identify novel therapeutic targets in chronic lung diseases such as idiopathic pulmonary fibrosis (IPF) and systemic sclerosis (SSc), and cystic fibrosis (CF). The lab’s early studies using several mouse models of fibrosis have revealed that multiple growth factors contribute to the deposition of collagen and other extracellular matrix (ECM) proteins in the lung. The lab’s recent studies have helped to define unique functions of fibrocytes and their heterogeneous interactions with other lung stromal cells in causing the expansion of adventitial and pleural fibrotic lesions in the lung.

Education and Training

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Postdoctoral training: Wynn Lab, Immunopathogenesis Section, LPD, NIAD, NIH, Bethesda, MD.

PhD: National Institute of Nutrition, Osmania University, Hyderabad, India.

Publications

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Madala SK*, Edukulla R, Davis KR, Schmidt SM, Davidson CR, Ikegami M. Hardie WD. Bone marrow-derived stromal cells are invasive and hyperproliferative and alter TGFα-induced fibrosis. Am J Respir Cell Mol Bio. 2014 Apr;50(4):777-86. * Corresponding author

Madala SK*, Edukulla R, Davis KR, Schmidt SM, Davidson CR, Kitzmiller JA, Hardie WD, Korfhagen TA. Resistin-like molecule alpha1 (Fizz1) recruits lung dendritic cells without causing pulmonary fibrosis . Respir Res . 2012 Jun 22;13:51. *Corresponding author

Madala SK, Schmidt SM, Davidson CR, Ikegami M, Susan W, Hardie WD. MEK-ERK pathway modulation ameliorates pulmonary fibrosis associated with epidermal growth factor receptor activation . Am J Respir Cell Mol Bio . 2012 Mar 46(3):380-8.

Wynn TA, Barron L, Thompson RW, Madala SK, Wilson MS, Cheever AW, Ramalingam TR. Quantitative Assessment of Macrophage Functions in Repair and Fibrosis . Curr Protoc Immunol . 2011 Apr; Chapter 14:Unit14.22.

Madala SK, Dolan M, Sharma D, Ramalingam TR, Wilson MS, Mentink-Kane MM,Wynn TA. Mapping mouse IL-13 binding regions using structure modeling, molecular docking and high-density peptide microarray analysis . Proteins . 2011 Jan;79(1):282-93.

Wilson MS, Ramalingam TR, Rivollier A, Shenderov K, Mentink-Kane MM, Madala SK, Cheever AW, Artis D, Kelsall BL, Wynn TA. Colitis and intestinal inflammation in IL10-/- mice results from IL-13Rα2-mediated attenuation of IL-13 activity . Gastroenterology . 2011 Jan;140(1):254-64 .

Wilson MS, Madala SK, Ramalingam TR, Thompson RW Mentink-Kane MM, Cheever AW, Wynn TA. Bleomycin and IL-1β mediated pulmonary fibrosis is regulated by IL-10 and dependent on IL-17A . J Exp Med . 2010 Mar 15;207(3):535-52.

Madala SK, Pesce J, Ramalingam TR, Wilson MS, Thompson RW, Minnicozzi S, Mentink-Kane MM, Cheever AW,Wynn TA. Matrix metalloproteinase 12-deficiency augments extracellular matrix degrading metalloproteinases and attenuates IL-13-dependent fibrosis . J Immunol . 2010 Apr 1;184(7):3955-63.

Ramalingam TR, Pesce JT, Mentink-Kane MM, Madala SK, Cheever AW, Comeau MR, Ziegler SF, Wynn TA. Regulation of helminth-induced Th2 responses by thymic stromal lymphopoietin . J Immunol . 2009 May 15;182(10):6452-9.

Grants

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Role of IL-31 in immunopathology of Systemic sclerosis (SSc). Principal Investigator. Bristol-Myers Squibb preclinical contract. 2013-2016. R03 NIAMS.

Molecular Mechanisms of Pulmonary Fibrosis. Principal Investigator. Parker B. Francis Fellowship. 2013-Dec 2016.