High Res

Satish K. Madala, PhD

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-9852

Email satish.madala@cchmc.org

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Specialties

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Pulmonary fibrosis, cystic fibrosis, scleroderma

Visit the Madala Lab.

Biography

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Dr. Satish K. Madala joined the Division of Pulmonary Medicine in 2011, after postdoctoral training in fibrotic disease research in the laboratory of Dr. Thomas A. Wynn, NIAID, NIH. Dr. Madala’s major research interests are to identify cellular and molecular mechanisms of human fibrotic lung diseases in particular idiopathic pulmonary fibrosis, cystic fibrosis, asthma and scleroderma. We use transgenic and non-transgenic mouse models to determine the molecular pathways that dictate pulmonary inflammation and fibrosis.

Education and Training

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Postdoctoral training: Wynn Lab, Immunopathogenesis Section, LPD, NIAD, NIH, Bethesda, MD.

PhD: National Institute of Nutrition, Osmania University, Hyderabad, India.

Publications

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Wang Y, Yella J, Chen J, McCormack F, Madala SK*, Jegga AG*. Unsupervised gene expression analyses identify IPF-severity correlated signatures, associated genes and biomarkers. BMC Pulmonary Medicine. 2017;17(1):133. *Co-corresponding authors.

Singh B, Kasam RK, Sontake V, Wynn TA, Madala SK. Repetitive Intradermal Bleomycin Injections Evokes T Helper Cell 2 Cytokine-driven Pulmonary Fibrosis. Am J Physiol Lung Cell Mol Physiol. 2017;313(5):L796-L806.

Sontake V, Wang Y, Kasam RK, McCormack FK, Debora S, Geereddy BR, Naren AP, White ES, Jegga AG, Madala SK. Hsp90 Regulation of Fibroblast Activation in Pulmonary Fibrosis. JCI insight. 2017;2:e91454.

Madala SK, Sontake V, Edukulla R, Davidson C, Schmidt S, Hardie WD. Unique and Redundant Functions of P70S6K Isoforms Regulate Mesenchymal Cell Proliferation and Migration in Pulmonary Fibrosis. Am J Respir Cell Mol Bio. 2016;55(6):792-803.

Sontake V, Kumar SA, Betsy DA, Mario M, Hardie WD, White ES, Madala SK. Fibrocytes Regulate Wilms Tumor 1-Positive Cell Accumulation in Severe Fibrotic Lung Disease. Journal of Immunology. 2015;195(8):3978-91.

Edukulla R, Singh B, Jegga A, Sontake V, Dillon SR, Madala SK. Th2 cytokines augment IL31-IL31RA interactions via STAT6-dependent IL-31RA expression. Journal of Biological Chemistry. 2015;290(21):13510-20.

Madala SK, Edukulla R, Davis KR, Schmidt SM, Davidson CR, Aciani T, LeCras T, Hardie WD. Dual Targeting of MEK and PI3K Pathways Attenuates Established and Progressive Pulmonary Fibrosis. PLoS One. 2014;e86536.

Madala SK, Dolan M, Sharma D, Ramalingam TR, Wilson MS, Mentink-Kane MM,Wynn TA. Mapping mouse IL-13 binding regions using structure modeling, molecular docking and high-density peptide microarray analysis. Proteins. 2011 Jan;79(1):282-93.

Wilson MS, Madala SK, Ramalingam TR, Thompson RW Mentink-Kane MM, Cheever AW, Wynn TA. Bleomycin and IL-1β mediated pulmonary fibrosis is regulated by IL-10 and dependent on IL-17A. J Exp Med. 2010 Mar 15;207(3):535-52.

Madala SK, Pesce J, Ramalingam TR, Wilson MS, Thompson RW, Minnicozzi S, Mentink-Kane MM, Cheever AW, Wynn TA. Opposing roles for matrix metalloproteinases 12 and 13 in interleukin 13-dependent tissue remodeling during S. mansoni egg induced fibrosis. J Immunology. 2010;184(7):3955-63.

Grants

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WT1 Regulation of Pulmonary Fibrosis. Principal Investigator. National Heart, Lung, and Blood Institute/National Institutes of Health. Jun 2017-May 2022. 1R01 HL134801.

Therapeutic Benefit of Hsp90 Inhibition in Pulmonary Fibrosis. Principal Investigator. DoDUSAMRAA. Sep 2017-Aug 2020.