Sujit Kumar Mohanty, DVM, PhD

A photo of Sujit Mohanty.

Assistant Professor, UC Department of Surgery

513-803-4415

Biography & Affiliation

Biography

Dr. Mohanty obtained his PhD from All India Institute of Medical Sciences, India in the field of viral immunology. In 2004 he moved to Cincinnati Children's Hospital Medical Center to study the pathogenesis of a neonatal disease of children called “Biliary atresia” in the laboratory of Dr. Jorge Bezerra. Later he moved to Pediatric Surgery division to continue his ongoing research. Since then he has been involved in various collaborative studies aiming to understand virus host interaction during infancy.

His research goals are to understand how a virus/viruses can induce liver fibrosis during neonatal period.

Research Interests

Biliary atresia and liver fibrosis; cholangiocyte biology/development; immunity to viruses

Academic Affiliation

Assistant Professor, UC Department of Surgery

Research Divisions

General and Thoracic Surgery

Education

BVSc & AH (DVM): Odisha University of Agriculture & Technology, Odisha, India.

MVSc: Indian Veterinary Research Institute, UP, India.

PhD: All India Institute of Medical Sciences, New Delhi, India.

Postdoctoral Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Publications

Selected Publication

Rotavirus Reassortant–Induced Murine Model of Liver Fibrosis Parallels Human Biliary Atresia. Mohanty, SK; Lobeck, I; Donnelly, B; Dupree, P; Walther, A; Mowery, S; Coots, A; Bondoc, A; Sheridan, RM; Poling, HM; et al. Hepatology. 2020; 71:1316-1330.

A rotavirus-induced mouse model to study biliary atresia and neonatal cholestasis. Mohanty, SK; Donnelly, B; Temple, H; Tiao, GM. Methods in molecular biology (Clifton, N.J.). 2019; 1981:259-271.

A Point Mutation in the Rhesus Rotavirus VP4 Protein Generated through a Rotavirus Reverse Genetics System Attenuates Biliary Atresia in the Murine Model. Mohanty, SK; Donnelly, B; Dupree, P; Lobeck, I; Mowery, S; Meller, J; McNeal, M; Tiao, G. Journal of Virology. 2017; 91.

The SRL Peptide of Rhesus Rotavirus VP4 Protein Governs Cholangiocyte Infection and the Murine Model of Biliary Atresia. Mohanty, SK; Donnelly, B; Lobeck, I; Walther, A; Dupree, P; Coots, A; Meller, J; McNeal, M; Sestak, K; Tiao, G. Hepatology. 2017; 65:1278-1292.

The Dendritic Cell-T Helper 17-Macrophage Axis Controls Cholangiocyte Injury and Disease Progression in Murine and Human Biliary Atresia. Lages, CS; Simmons, J; Maddox, A; Jones, K; Karns, R; Sheridan, R; Shanmukhappa, SK; Mohanty, S; Kofron, M; Russo, P; et al. Hepatology. 2017; 65:174-188.

Rhesus rotavirus VP4 sequence-specific activation of mononuclear cells is associated with cholangiopathy in murine biliary atresia. Walther, A; Mohanty, SK; Donnelly, B; Coots, A; Lages, CS; Lobeck, I; Dupree, P; Meller, J; McNeal, M; Sestak, K; et al. American Journal of Physiology: Gastrointestinal and Liver Physiology. 2015; 309:G466-G474.

Rotavirus Replication in the Cholangiocyte Mediates the Temporal Dependence of Murine Biliary Atresia. Mohanty, SK; Donnelly, B; Bondoc, A; Jafri, M; Walther, A; Coots, A; McNeal, M; Witte, D; Tiao, GM. PLoS ONE. 2013; 8:e69069-e69069.

The Rhesus Rotavirus Gene Encoding VP4 Is a Major Determinant in the Pathogenesis of Biliary Atresia in Newborn Mice. Wang, W; Donnelly, B; Bondoc, A; Mohanty, SK; McNeal, M; Ward, R; Sestak, K; Zheng, S; Tiao, G. Journal of Virology. 2011; 85:9069-9077.

Editorial: Macrophages in Liver Disease. Bansal, R; Mandrekar, P; Mohanty, SK; Weiskirchen, R. Frontiers in Immunology. 2020; 11.

Innate Immunity and Pathogenesis of Biliary Atresia. Ortiz-Perez, A; Donnelly, B; Temple, H; Tiao, G; Bansal, R; Mohanty, SK. Frontiers in Immunology. 2020; 11.