A photo of Sujit Mohanty.

Sujit Kumar Mohanty, DVM, PhD

  • Assistant Professor, UC Department of Surgery

About

Biography

Dr. Mohanty obtained his PhD from All India Institute of Medical Sciences, India in the field of viral immunology. In 2004 he moved to Cincinnati Children's Hospital Medical Center to study the pathogenesis of a neonatal disease of children called “Biliary atresia” in the laboratory of Dr. Jorge Bezerra. Later he moved to Pediatric Surgery division to continue his ongoing research. Since then he has been involved in various collaborative studies aiming to understand virus host interaction during infancy.

His research goals are to understand how a virus/viruses can induce liver fibrosis during neonatal period.

BVSc & AH (DVM): Odisha University of Agriculture & Technology, Odisha, India.

MVSc: Indian Veterinary Research Institute, UP, India.

PhD: All India Institute of Medical Sciences, New Delhi, India.

Postdoctoral Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Interests

Biliary atresia and liver fibrosis; cholangiocyte biology/development; immunity to viruses

Research Areas

General and Thoracic Surgery

Publications

Selected

Rotavirus Reassortant-Induced Murine Model of Liver Fibrosis Parallels Human Biliary Atresia. Mohanty, SK; Lobeck, I; Donnelly, B; Dupree, P; Walther, A; Mowery, S; Coots, A; Bondoc, A; Sheridan, RM; Poling, HM; et al. Hepatology. 2020; 71:1316-1330.

Selected

A Rotavirus-Induced Mouse Model to Study Biliary Atresia and Neonatal Cholestasis. Mohanty, SK; Donnelly, B; Temple, H; Tiao, GM. Methods in Molecular Biology. 2019; 1981:259-271.

Selected

A Point Mutation in the Rhesus Rotavirus VP4 Protein Generated through a Rotavirus Reverse Genetics System Attenuates Biliary Atresia in the Murine Model. Mohanty, SK; Donnelly, B; Dupree, P; Lobeck, I; Mowery, S; Meller, J; McNeal, M; Tiao, G. Journal of Virology. 2017; 91.

Selected

The SRL peptide of rhesus rotavirus VP4 protein governs cholangiocyte infection and the murine model of biliary atresia. Mohanty, SK; Donnelly, B; Lobeck, I; Walther, A; Dupree, P; Coots, A; Meller, J; McNeal, M; Sestak, K; Tiao, G. Hepatology. 2017; 65:1278-1292.

Selected

The dendritic cell-T helper 17-macrophage axis controls cholangiocyte injury and disease progression in murine and human biliary atresia. Lages, CS; Simmons, J; Maddox, A; Jones, K; Karns, R; Sheridan, R; Shanmukhappa, SK; Mohanty, S; Kofron, M; Russo, P; et al. Hepatology. 2017; 65:174-188.

Selected

Rhesus rotavirus VP4 sequence-specific activation of mononuclear cells is associated with cholangiopathy in murine biliary atresia. Walther, A; Mohanty, SK; Donnelly, B; Coots, A; Lages, CS; Lobeck, I; Dupree, P; Meller, J; McNeal, M; Sestak, K; et al. American Journal of Physiology - Gastrointestinal and Liver Physiology. 2015; 309:G466-G474.

Selected

Rotavirus replication in the cholangiocyte mediates the temporal dependence of murine biliary atresia. Mohanty, SK; Donnelly, B; Bondoc, A; Jafri, M; Walther, A; Coots, A; McNeal, M; Witte, D; Tiao, GM. PLoS ONE. 2013; 8.

Selected

The rhesus rotavirus gene encoding VP4 is a major determinant in the pathogenesis of biliary atresia in newborn mice. Wang, W; Donnelly, B; Bondoc, A; Mohanty, SK; McNeal, M; Ward, R; Sestak, K; Zheng, S; Tiao, G. Journal of Virology. 2011; 85:9069-9077.

High Mobility Group Box 1 Release by Cholangiocytes Governs Biliary Atresia Pathogenesis and Correlates With Increases in Afflicted Infants. Mohanty, SK; Donnelly, B; Temple, H; Ortiz-Perez, A; Mowery, S; Lobeck, I; Dupree, P; Poling, HM; McNeal, M; Mourya, R; et al. Hepatology. 2021; 74:864-878.

Editorial: Macrophages in Liver Disease. Bansal, R; Mandrekar, P; Mohanty, SK; Weiskirchen, R. Frontiers in Immunology. 2020; 11.