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Assistant Professor, UC Department of Pediatrics

513-803-5066

Biography & Affiliation

Biography

As a research scientist, my interests include lung biology and diseases of the lung. The goals of my lab are to determine the mechanisms of lung diseases and to identify therapeutics to treat lung disease.

My education in veterinary school led to my interest in research. It helped me realize that to discover therapies for lung disease, I first needed to understand basic lung biology. I’m dedicated to this study and hope to discover therapies for lung diseases that have no known treatments.

One of my discoveries is identifying the roles of lung transcription factors that regulate the production of mucus, contributing to the severity of asthma, cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and lung cancer. This discovery led to the identification of potential therapeutic targets to control hyper-secreting mucus and lung tumor growth.

I have more than16 years of research experience and started working at Cincinnati Children’s in 2004. My research has been published in various respected journals, including Oncogene, EMBO Molecular Medicine, Journal of Clinical Investigation and American Journal of Respiratory and Critical Care Medicine.

Academic Affiliation

Assistant Professor, UC Department of Pediatrics

Research Divisions

Pulmonary Biology

Education

DVM: Hokkaido University, Sapporo, Japan, 1997.

PhD: University of California, Riverside, CA, 2002.

Publications

CRISPRi-mediated functional analysis of lung disease-associated loci at non-coding regions. Stuart, WD; Guo, M; Fink-Baldauf, IM; Coleman, AM; Clancy, JP; Mall, MA; Lim, F; Brewington, JJ; Maeda, Y. 2020; 2.

An EGFR ligand promotes EGFR-mutant but not KRAS-mutant lung cancer in vivo. Tomoshige, K; Guo, M; Tsuchiya, T; Fukazawa, T; Fink-Baldauf, IM; Stuart, WD; Naomoto, Y; Nagayasu, T; Maeda, Y. Oncogene: Including Oncogene Reviews. 2018; 37:3894-3908.

Gene signature driving invasive mucinous adenocarcinoma of the lung. Guo, M; Tomoshige, K; Meister, M; Muley, T; Fukazawa, T; Tsuchiya, T; Karns, R; Warth, A; Fink-Baldauf, IM; Nagayasu, T; et al. EMBO Molecular Medicine. 2017; 9:462-481.

SOX2 suppresses CDKN1A to sustain growth of lung squamous cell carcinoma. Fukazawa, T; Guo, M; Ishida, N; Yamatsuji, T; Takaoka, M; Yokota, E; Haisa, M; Miyake, N; Ikeda, T; Okui, T; et al. Scientific Reports. 2016; 6.