Cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated chloride channel located primarily on the apical surface of epithelial cells that line various organs, including the airways and the gut. CFTR dysfunction is detrimental and may result in life-threatening medical disorders. Dr. Naren's laboratory studies two such disorders; (1) Cystic fibrosis, a lethal genetic disease that affects mostly the Caucasian population (>30,000 in USA), in which the CFTR chloride channel is HYPO-functional and (2) Secretory diarrhea, a disease affecting millions of children worldwide, in which HYPER-function of the CFTR chloride channel can occur due to infectious toxins, such as cholera toxin and E. coli enterotoxin. His lab is interested in identifying interactions between CFTR and its binding partners and defining how spatiotemporal regulation of CFTR-containing macromolecular complexes in the apical compartment of polarized epithelial cells lining the secretory epithelia regulates overall fluid secretion. Our studies will identify new drug targets for cystic fibrosis, secretory diarrhea, and other diseases resulting from CFTR dysfunction and provide insights into the etiology of diseases associated with CFTR-interacting molecules.
Cystic Fibrosis Center
Cystic fibrosis; secretory diarrhea.
Epithelial SMYD5 Exaggerates IBD by Down-regulating Mitochondrial Functions via Post-Translational Control of PGC-1α Stability. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2022; 14:375-403.
Is There a Benefit From Islet Autotransplantation in Patients With Type 1 Diabetes Mellitus Undergoing Total Pancreatectomy?. Pancreas. 2022; 51:399-403.
5.06 Pharmacology of Secretory Diarrhea. Comprehensive Pharmacology. 2022.
Crystal structure of RahU, an aegerolysin protein from the human pathogen Pseudomonas aeruginosa, and its interaction with membrane ceramide phosphorylethanolamine. Scientific Reports. 2021; 11.
Evaluation of Risk Scores to Predict Pediatric Severe Asthma Exacerbations. Journal of Allergy and Clinical Immunology: In Practice. 2021; 9:4393-4401.e8.
Elexacaftor/Tezacaftor/Ivacaftor Improved Clinical Outcomes in a Patient with N1303K-CFTR Based on In Vitro Experimental Evidence. American Journal of Respiratory and Critical Care Medicine. 2021; 204:1231-1235.
Cystic Fibrosis Human Organs-on-a-Chip. Micromachines. 2021; 12.
Patient personalized translational tools in cystic fibrosis to transform data from bench to bed-side and back. American Journal of Physiology - Gastrointestinal and Liver Physiology. 2021; 320:G1123-G1130.
F1099L-CFTR (c.3297C>G) has Impaired Channel Function and Associates with Mild Disease Phenotypes in Two Pediatric Patients. Life. 2021; 11.
A SNARE protein Syntaxin 17 captures CFTR to potentiate autophagosomal clearance under stress. FASEB Journal. 2021; 35.
Anjaparavanda P. "AP" Naren, PhD8/12/2019