Yuya Ogawa, PhD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-1949

Fax 513-803-1160

Email yuya.ogawa@cchmc.org

In mammalian females, one of the two X-chromosomes is silenced to correct the imbalance of X-linked gene dosage between males (Xy) and females (XX). This chromosome-wide gene silencing is induced by a long noncoding RNA, Xist RNA.

The laboratory is interested in the mechanisms of: (1) how the chromosome-wide silencing is induced by Xist RNA and (2) how the long-range silencing is maintained and organized. Their long-term goal is to understand how noncoding RNAs impact gene regulation and development in animals.

BS: Molecular Biology, Nagoya University, Japan, 1992.

MS: Molecular Biology, Nagoya University, Japan, 1994.

PhD: Biology, Osaka University, Japan, 1998.

View PubMed Publications

Daikoku T, Ogawa Y, Terakawa J, Ogawa A, DeFalco T, Dey SK. Lactoferrin-iCre: a new mouse line to study uterine epithelial gene function. Endocrinology. 2014 Jul;155(7):2718-24.

Sun S, Del Rosario BC, Szanto A, Ogawa Y, Jeon Y, Lee JT. Jpx RNA activates Xist by evicting CTCF. Cell. 2013 Jun 20;153(7):1537-51.

Sato A, Yamada N, Ogawa Y, Ikegami M. CCAAT/enhancer-binding protein-α suppresses lung tumor development in mice through the p38α MAP kinase pathway. PLoS One. 2013;8(2):e57013.

Zhao J, Ohsumi TK, Kung JT, Ogawa Y, Grau DJ, Sarma K, Song JJ, Kingston RE, Borowsky M, Lee JT. Genome-wide identification of polycomb-associated RNAs by RIP-seq. Mol Cell. 2010 Dec 22;40(6):939-53.

Zhang LF, Ogawa Y, Ahn JY, Namekawa SH, Silva SS, Lee JT. Telomeric RNAs mark sex chromosomes in stem cells. Genetics. 2009 182,685-98.

Ogawa Y, Sun BK, Lee JT. Intersection of the RNA interference and X-inactivation pathways. Science. 2008 320,1336-41.