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Assistant Professor, UC Department of Pediatrics
In mammalian females, one of the two X-chromosomes is silenced to correct the imbalance of X-linked gene dosage between males (Xy) and females (XX). This chromosome-wide gene silencing is induced by a long noncoding RNA, Xist RNA.
The laboratory is interested in the mechanisms of: (1) how the chromosome-wide silencing is induced by Xist RNA and (2) how the long-range silencing is maintained and organized. Their long-term goal is to understand how noncoding RNAs impact gene regulation and development in animals.
BS: Molecular Biology, Nagoya University, Japan, 1992.
MS: Molecular Biology, Nagoya University, Japan, 1994.
PhD: Biology, Osaka University, Japan, 1998.
The uterine epithelial loss of Pten is inefficient to induce endometrial cancer with intact stromal Pten.
Liang, X; Daikoku, T; Terakawa, J; Ogawa, Y; Joshi, AR; Ellenson, LH; Sun, X; Dey, SK.
CRISPR/Cas9-mediated modulation of splicing efficiency reveals short splicing isoform of Xist RNA is sufficient to induce X-chromosome inactivation.
Yue, M; Ogawa, Y.
Nucleic Acids Research.
N-6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications.
Wang, Y; Li, Y; Yue, M; Wang, J; Kumar, S; Wechsler-Reya, RJ; Zhang, Z; Ogawa, Y; Kellis, M; Duester, G; et al.
Xist RNA repeat E is essential for ASH2L recruitment to the inactive X and regulates histone modifications and escape gene expression.
Yue, M; Ogawa, A; Yamada, N; Richard, JL C; Barski, A; Ogawa, Y.
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