Alexey Porollo, PhD

Member, Center for Autoimmune Genomics and Etiology

Member, Division of Biomedical Informatics

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

UC Department of Environmental Health

Phone 513-803-5489


Computational biology; bioinformatics
Visit the Porollo Lab website.
Alexey Porollo, PhD, is a computational biologist with research focused on the development of new prediction and analytical methods in structural bioinformatics. Applications of computational approaches include structural and functional characterization of proteins and their mutations, rational protein engineering, analysis of biological pathways, identification of new drug targets, virtual drug screening, and microbiome analysis.

MSc: Mari State University, Yoshkar-Ola, Russia, 1995.

PhD: Tver State University, Tver and Mari State University, Yoshkar-Ola, Russia, 1999.

Post-doc: Children’s Hospital Medical Center, Cincinnati, OH, 2006.

View Publications on Google Scholar

Porollo A, Sesterhenn TM, Collins MS, Welge JA, Cushion MT. Comparative Genomics of Pneumocystis Species Suggests the Absence of Genes for myo-Inositol Synthesis and Reliance on Inositol Transport and Metabolism. MBio. 2014 Nov 4;5(6).

Fechter K, Porollo A. MutaCYP: Classification of missense mutations in human cytochromes P450. BMC Med Genomics. 2014 Jul 30;7(1):47.

Subramanian Vignesh K, Landero Figueroa JA, Porollo A, Caruso JA, Deepe GS Jr. Granulocyte macrophage-colony stimulating factor induced Zn sequestration enhances macrophage superoxide and limits intracellular pathogen survivalImmunity. 2013 Oct 17;39(4):697-710.

Syed K, Porollo A, Miller D, Yadav JS. Rational engineering of the fungal P450 monooxygenase CYP5136A3 to improve its oxidizing activity toward polycyclic aromatic hydrocarbons. Protein Eng Des Sel. 2013 Sep;26(9):553-7.

Green JV, Orsborn KI, Zhang M, Tan QK, Greis KD, Porollo A, Andes DR, Long Lu J, Hostetter MK. Heparin-binding motifs and biofilm formation by Candida albicans. J Infect Dis. 2013 Nov 15;208(10):1695-704.

Ma L, Tao Y, Duran A, Llado V, Galvez A, Barger JF, Castilla EA, Chen J, Yajima T, Porollo A, Medvedovic M, Brill LM, Plas DR, Riedl SJ, Leitges M, Diaz-Meco MT, Richardson AD, Moscat J. Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis. Cell. 2013 Jan 31;152(3):599-611.  

Porollo A, Meller J, Joshi Y, Jaiswal V, Smulian AG, Cushion MT. Analysis of current antifungal agents and their targets within the Pneumocystis carinii genome. Curr Drug Targets. 2012 Nov;13(12):1575-85.

Duran A, Amanchy R, Linares JF, Joshi J, Abu-Baker S, Porollo A, Hansen M, Moscat J, Diaz-Meco MT. p62 is a key regulator of nutrient sensing in the mTORC1 pathway. Mol Cell. 2011 Oct 7;44(1):134-46.

Porollo A, Meller J. Prediction-based fingerprints of protein-protein interactions. Proteins. 2007 Feb 15;66(3):630-45.

Adamczak R, Porollo A, Meller J. Accurate prediction of solvent accessibility using neural networks-based regression. Proteins. 2004 Sep 1;56(4):753-67.

Directed Culturing of Pneumocystis Using Metatranscriptomics. Co-Principal Investigator. National Institutes of Health: Heart, Lung and Blood Institute. May 2013-Feb 2018. R01HL119190-01.

GM-CSF-Induced Metal Sequestration and Histoplasma. Co-Investigator. National Institute of Allergy and Infectious Diseases. May 2013–Apr 2018. 1R01AI106269-01.

Suppression of IgE-Mediated Disease by Polyclonal Rapid Desensitization. Co-Investigator. National Institute of Allergy and Infectious Diseases. Jul 2014-Jun 2019. 1R01AI113162-01.