Alexey Porollo, PhD

Member, Center for Autoimmune Genomics and Etiology

Member, Division of Biomedical Informatics

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-803-5489


Computational biology; bioinformatics
Visit the Porollo Lab website.
Dr. Porollo is a computational biologist with research focused on the development of new prediction and analytical methods in structural bioinformatics. Applications of computational approaches include structural and functional characterization of proteins and their mutations, rational protein engineering, analysis of biological pathways, identification of new drug targets, virtual drug screening, and microbiome analysis.

MSc: Mari State University, Yoshkar-Ola, Russia, 1995.

PhD: Tver State University, Tver and Mari State University, Yoshkar-Ola, Russia, 1999.

Post-doc: Children’s Hospital Medical Center, Cincinnati, OH, 2006.

View Publications on Google Scholar

Baker FN, Porollo A. CoeViz: a web-based tool for coevolution analysis of protein residues. BMC Bioinformatics. 2016 Mar 8;17:119.  

Porollo A, Sesterhenn TM, Collins MS, Welge JA, Cushion MT. Comparative Genomics of Pneumocystis Species Suggests the Absence of Genes for myo-Inositol Synthesis and Reliance on Inositol Transport and Metabolism. MBio. 2014 Nov 4;5(6).

Syed K, Porollo A, Miller D, Yadav JS. Rational engineering of the fungal P450 monooxygenase CYP5136A3 to improve its oxidizing activity toward polycyclic aromatic hydrocarbons. Protein Eng Des Sel. 2013 Sep;26(9):553-7.

Porollo A, Meller J. POLYVIEW-MM: web-based platform for animation and analysis of molecular simulations. Nucleic Acids Res. 2010 Jul;38(Web Server issue):W662-6.

Porollo A, Meller J. Prediction-based fingerprints of protein-protein interactions. Proteins. 2007 Feb 15;66(3):630-45.

Directed Culturing of Pneumocystis Using Metatranscriptomics. Co-Principal Investigator. National Institutes of Health: Heart, Lung and Blood Institute. May 2013-Feb 2018. R01HL119190-01.

GM-CSF-Induced Metal Sequestration and Histoplasma. Co-Investigator. National Institute of Allergy and Infectious Diseases. May 2013–Apr 2018. 1R01AI106269-01.

Suppression of IgE-Mediated Disease by Polyclonal Rapid Desensitization. Co-Investigator. National Institute of Allergy and Infectious Diseases. Jul 2014-Jun 2019. 1R01AI113162-01.