A photo of Carlos Prada.

Co-Director, RASopathy Program

Co-Director, Neurofibromatosis Program

Associate Professor, UC Department of Pediatrics



Board Certified

About Me


Early in my medical school training, I was moved by many families who had children with unanswered medical concerns and a lack of treatment options. I felt motivated to help families without answers and to develop new ways to treat rare diseases.

As a clinical and biochemical geneticist, I treat children and adolescents with:

  • Lysosomal storage diseases
  • Metabolic diseases
  • Neurofibromatosis
  • mTORopathies
  • RASopathies

I listen with attention to patient and family concerns, and we develop treatment plans together. I actively look for new therapeutic opportunities and how to improve symptoms and quality of life when no standard of treatment exists.

We have developed a comprehensive team of providers and medical specialists to facilitate our understanding of diseases, anticipate complications and develop treatment plans. We constantly look at our treatment and management outcomes and for ways to improve them.

I co-direct the RASopathy Program and the Neurofibromatosis Program at Cincinnati Children’s, and I am also involved in education as the director of our Clinical Biochemical Genetics Fellowship Program.

I have been involved in providing care overseas in Colombia and the Dominican Republic. I work with various foundations to facilitate the identification and management of patients with rare diseases. In the United States, I work with family foundation groups to help them identify needs and access care. I am also the associate editor of the American Journal of Medical Genetics.

In my research, my colleagues and I are looking at ways to identify new treatment opportunities, develop biomarkers, and understand risk factors and modifiers that can help us anticipate medical problems or become treatment opportunities. We also work with collaborators to model genetic disorders for future treatment development.

During my free time, I enjoy traveling and cooking with my family.

Additional Languages


Clinical Interests

RASopathies; neurofibromatosis; lysosomal storage diseases; metabolic diseases; mTORopathies

Research Interests

Treatment development for RASopathies and metabolic disorders; gene discovery and natural history of rare disorders

Academic Affiliation

Associate Professor, UC Department of Pediatrics

Clinical Divisions

Genetics, Rasopathy, Neurofibromatosis

Blog Posts

My Locations

My Education

MD: Universidad Industrial de Santander, Bucaramanga, Colombia.

Residency: Cincinnati Children’s Hospital Medical Center Pediatrics/Human Genetics, Cincinnati, OH, 2006-2011.

Fellowship: Cincinnati Children’s Hospital Medical Center Clinical Biochemical Genetics, Cincinnati, OH, 2011-2013.

Certification: Clinical Genetics, 2013; Clinical Biochemical Genetics, 2013.

My Publications

Loss- or Gain-of-Function Mutations in ACOX1 Cause Axonal Loss via Different Mechanisms. Chung, H; Wangler, MF; Marcogliese, PC; Jo, J; Ravenscroft, TA; Zuo, Z; Duraine, L; Sadeghzadeh, S; Li-Kroeger, D; Schmidt, RE; et al. Neuron. 2020; 106:589-606.e6.

The sixth international RASopathies symposium: Precision medicine—From promise to practice. Gripp, KW; Schill, L; Schoyer, L; Stronach, B; Bennett, AM; Blaser, S; Brown, A; Burdine, R; Burkitt-Wright, E; Castel, P; et al. American Journal of Medical Genetics, Part A. 2020; 182:597-606.

Disruptive variants of CSDE1 associate with autism and interfere with neuronal development and synaptic transmission. Guo, H; Li, Y; Shen, L; Wang, T; Jia, X; Liu, L; Xu, T; Ou, M; Hoekzema, K; Wu, H; et al. Science Advances. 2019; 5:eaax2166-eaax2166.

Expanding and Underscoring the Hepato-Encephalopathic Phenotype of QIL1/MIC13. Russell, BE; Whaley, KG; Bove, KE; Labilloy, A; Lombardo, RC; Hopkin, RJ; Leslie, ND; Prada, C; Assouline, Z; Barcia, G; et al. Hepatology. 2019; 70:1066-1070.

Phenotypic and biochemical analysis of an international cohort of individuals with variants in NAA10 and NAA15. Cheng, H; Gottlieb, L; Marchi, E; Kleyner, R; Bhardwaj, P; Rope, AF; Rosenheck, S; Moutton, S; Philippe, C; Eyaid, W; et al. Human Molecular Genetics. 2019; 28:2900-2919.

Mutations in the Neuronal Vesicular SNARE VAMP2 Affect Synaptic Membrane Fusion and Impair Human Neurodevelopment. Salpietro, V; Malintan, NT; Llano-Rivas, I; Spaeth, CG; Efthymiou, S; Striano, P; Vandrovcova, J; Cutrupi, MC; Chimenz, R; David, E; et al. The American Journal of Human Genetics. 2019; 104:721-730.

Substantial pain burden in frequency, intensity, interference and chronicity among children and adults with neurofibromatosis Type 1. Kongkriangkai, AM; King, C; Martin, LJ; Wakefield, E; Prada, CE; Kelly-Mancuso, G; Schorry, EK. American Journal of Medical Genetics, Part A. 2019; 179:602-607.

Prevalence of pathogenic and likely pathogenic variants in the RASopathy genes in patients who have had panel testing for cardiomyopathy. Aljeaid, D; Isabel Sanchez, A; Wakefield, E; Chadwell, SE; Moore, N; Prada, CE; Zhang, W. American Journal of Medical Genetics, Part A. 2019; 179:608-614.

Vitamin D deficiency and pre-eclampsia in Colombia: PREVitD study. Serrano, NC; Guio, E; Quintero-Lesmes, DC; Becerra-Bayona, S; Luna-Gonzalez, ML; Herrera, VM; Prada, CE. Pregnancy Hypertension. 2018; 14:240-244.

Lysosomal Acid Lipase Deficiencies: Wolman Disease/ Cholesteryl Ester Storage Disease. Prada, CE; Grabowski, GA. In: KLEINMAN RE, Ed. Walker´s Pediatric Gastroenterology Diseases: Physiology, Diagnosis, and Management.. Raleigh, North Carolina: PMPH; 2018.