A photo of Dao Pan.

Dao Pan, PhD

  • Member, Division of Experimental Hematology & Cancer Biology
  • Professor, UC Department of Pediatrics


BS: Peking Normal University, Beijing, China, 1988.

MS: Peking Normal University, Beijing, China, 1991.

PhD: University of Minnesota, Minneapolis, MN, 1997.


Hematopoietic stem cells; mesenchymal stem/progenitor cells; gene therapy; human genetics; translational research; lysosomal storage diseases

Research Areas

Experimental Hematology and Cancer Biology, Cancer and Blood Diseases



Platelets are efficient and protective depots for storage, distribution, and delivery of lysosomal enzyme in mice with Hurler syndrome. Dai, M; Han, J; El-Amouri, SS; Brady, RO; Pan, D. Proceedings of the National Academy of Sciences of USA. 2014; 111:2680-2685.


Engineering a lysosomal enzyme with a derivative of receptor-binding domain of apoE enables delivery across the blood-brain barrier. Wang, D; El-Amouri, SS; Dai, M; Kuan, C; Hui, DY; Brady, RO; Pan, D. Proceedings of the National Academy of Sciences of USA. 2013; 110:2999-3004.


K-Cl cotransporter gene expression during human and murine erythroid differentiation. Pan, D; Kalfa, TA; Wang, D; Risinger, M; Crable, S; Ottlinger, A; Chandra, S; Mount, DB; Huebner, CA; Franco, RS; et al. The Journal of biological chemistry. 2011; 286:30492-30503.


Reprogramming erythroid cells for lysosomal enzyme production leads to visceral and CNS cross-correction in mice with Hurler syndrome. Wang, D; Zhang, W; Kalfa, TA; Grabowski, G; Davies, S; Malik, P; Pan, D. Proceedings of the National Academy of Sciences of USA. 2009; 106:19958-19963.


In vivo gene transfer into adult stem cells in unconditioned mice by in situ delivery of a lentiviral vector. Worsham, DN; Schuesler, T; von Kalle, C; Pan, D. Molecular Therapy. 2006; 14:514-524.


Biodistribution and toxicity studies of VSVG-pseudotyped lentiviral vector after intravenous administration in mice with the observation of in vivo transduction of bone marrow. Pan, D; Gunther, R; Duan, WM; Wendell, S; Kaemmerer, W; Kafri, T; Verma, IM; Whitley, CB. Molecular Therapy. 2002; 6:19-29.

A multifaceted evaluation of microgliosis and differential cellular dysregulations of mTOR signaling with fluctuating lysosome function in neuronopathic Gaucher disease. Zhang, Z; Wang, X; Lin, Y; Pan, D. Molecular Genetics and Metabolism. 2023; 138:107366.