BS: Peking Normal University, Beijing, China, 1988.
MS: Peking Normal University, Beijing, China, 1991.
PhD: University of Minnesota, Minneapolis, MN, 1997.
Hematopoietic stem cells; mesenchymal stem/progenitor cells; gene therapy; human genetics; translational research; lysosomal storage diseases
Experimental Hematology and Cancer Biology, Cancer and Blood Diseases
Normalization and improvement of CNS deficits in mice with Hurler syndrome after long-term peripheral delivery of BBB-targeted iduronidase. Molecular Therapy. 2014; 22:2028-2037.
Platelets are efficient and protective depots for storage, distribution, and delivery of lysosomal enzyme in mice with Hurler syndrome. Proceedings of the National Academy of Sciences of USA. 2014; 111:2680-2685.
Engineering a lysosomal enzyme with a derivative of receptor-binding domain of apoE enables delivery across the blood-brain barrier. Proceedings of the National Academy of Sciences of USA. 2013; 110:2999-3004.
K-Cl cotransporter gene expression during human and murine erythroid differentiation. The Journal of biological chemistry. 2011; 286:30492-30503.
Reprogramming erythroid cells for lysosomal enzyme production leads to visceral and CNS cross-correction in mice with Hurler syndrome. Proceedings of the National Academy of Sciences of USA. 2009; 106:19958-19963.
In vivo gene transfer into adult stem cells in unconditioned mice by in situ delivery of a lentiviral vector. Molecular Therapy. 2006; 14:514-524.
A multifaceted evaluation of microgliosis and differential cellular dysregulations of mTOR signaling with fluctuating lysosome function in neuronopathic Gaucher disease. Molecular Genetics and Metabolism. 2023; 138:107366.