A photo of Dao Pan.

Member, Division of Experimental Hematology & Cancer Biology

Associate Professor, UC Department of Pediatrics

513-636-6315

513-636-1330

Biography & Affiliation

Clinical Interests

Hematopoietic stem cells; mesenchymal stem/progenitor cells; gene therapy; human genetics; translational research; lysosomal storage diseases

Academic Affiliation

Associate Professor, UC Department of Pediatrics

Departments

Experimental Hematology and Cancer Biology, Cancer and Blood Diseases

Education

BS: Peking Normal University, Beijing, China, 1988.

MS: Peking Normal University, Beijing, China, 1991.

PhD: University of Minnesota, Minneapolis, MN, 1997.

Publications

Selected Publication

Comprehensive evaluation of blood-brain barrier-forming micro-vasculatures: Reference and marker genes with cellular composition. Dai, M; Lin, Y; El-Amouri, SS; Kohls, M; Pan, D. PLoS ONE. 2018; 13:e0197379-e0197379.

Normalization and Improvement of CNS Deficits in Mice With Hurler Syndrome After Long-term Peripheral Delivery of BBB-targeted Iduronidase. El-Amouri, SS; Dai, M; Han, J; Brady, RO; Pan, D. Molecular Therapy. 2014; 22:2028-2037.

Platelets are efficient and protective depots for storage, distribution, and delivery of lysosomal enzyme in mice with Hurler Syndrome. Dai, M; Han, J; El-Amouri, SS; Brady, RO; Pan, D. Proceedings of the National Academy of Sciences of USA. 2014; 111:2680-2685.

Engineering a lysosomal enzyme with a derivative of receptor-binding domain of apoE enables delivery across the blood-brain barrier. Wang, D; El-Amouri, SS; Dai, M; Kuan, C; Hui, DY; Brady, RO; Pan, D. Proceedings of the National Academy of Sciences of USA. 2013; 110:2999-3004.

K-Cl Cotransporter Gene Expression during Human and Murine Erythroid Differentiation. Pan, D; Kalfa, TA; Wang, D; Risinger, M; Crable, S; Ottlinger, A; Chandra, S; Mount, DB; Huebner, CA; Franco, RS; et al. The Journal of biological chemistry. 2011; 286:30492-30503.

Reprogramming erythroid cells for lysosomal enzyme production leads to visceral and CNS cross-correction in mice with Hurler syndrome. Wang, D; Zhang, W; Kalfa, TA; Grabowski, G; Davies, S; Malik, P; Pan, D. Proceedings of the National Academy of Sciences of USA. 2009; 106:19958-19963.

In vivo gene transfer into adult stem cells in unconditioned mice by lentiviral in situ delivery of a vector. Worsham, DN; Schuesler, T; von Kalle, C; Pan, D. Molecular Therapy. 2006; 14:514-524.

Biodistribution and toxicity studies of VSVG-pseudotyped lentiviral vector after intravenous administration in mice with the observation of in vivo transduction of bone marrow. Pan, D; Gunther, R; Duan, WM; Wendell, S; Kaemmerer, W; Kafri, T; Verma, IM; Whitley, CB. Molecular Therapy. 2002; 6:19-29.

Combined ultrafiltration-transduction in a hollow-fiber bioreactor facilitates retrovirus-mediated gene transfer into peripheral blood lymphocytes from patients with mucopolysaccharidosis type II. Pan, D; Shankar, R; Stroncek, DF; Whitley, CB. Human Gene Therapy. 1999; 10:2799-2810.

Loss of BRUCE reduces cellular energy level and induces autophagy by driving activation of the AMPK-ULK1 autophagic initiating axis. Che, L; Yang, X; Ge, C; El-Amouri, SS; Wang, Q; Pan, D; Herzog, TJ; Du, C. PLoS ONE. 2019; 14:e0216553-e0216553.