Ernest Pedapati, MD, MS, FAAP
- Member, Division of Child and Adolescent Psychiatry
- Member, Division of Neurology
- Professor, UC Department of Psychiatry and Behavioral Neuroscience
- Board Certified
About
Biography
I specialize in the treatment of neuropsychiatric diseases associated with ASD, genetic, and other neurodevelopmental disorders, including interdisciplinary treatment planning and advanced medication management. Prior to my faculty appointment, I received clinical and research training under Craig Erickson, MD, and pediatric transcranial magnetic stimulation under Donald Gilbert, MD, MS.
In 2013, I successfully designed and obtained IRB approval and competitive funding for a TMS project through the American Academy of Child & Adolescent Psychiatry Pilot Research Award. I am currently completing the study, "Cortical Plasticity in Adolescent Depression," which aims to use TMS to determine whether abnormal neuroplasticity can be quantified in adolescent depression.
During my final year of residency, I applied for and secured a highly competitive institutional mentor career development award (Procter Scholar), which allowed me to dedicate 90% of my time to independent research activities. This included obtaining preliminary data on TMS measures of cortical plasticity in ASD and developing an implicit false belief task of social cognition for future TMS modulation. Additionally, I continue to be an active subinvestigator, extensively contributing to an NIH R01 project examining TMS measures of motor physiology in ADHD. I pioneered the use of SICI as a biomarker in ADHD and the measurement of cortical plasticity in healthy youth.
MD: University of Massachusetts, Worcester, MA, 2009.
Residency: Pediatrics/Adult Psychiatry/Child Psychiatry, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Certification: Child and Adolescent Psychiatry, Adult Psychiatry, Addiction Psychiatry.
Interests
Neurodevelopmental disorders; fragile x syndrome; autism spectrum disorder; ADHD; severe, refractory mental illness
Interests
Clinical trials; brain computer interface; transcranial magnetic stimulation; gene therapy; fragile x syndrome; EEG
Locations (2)
Insurance Information
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Publications
Impaired perceptual learning in a mouse model of Fragile X syndrome is mediated by parvalbumin neuron dysfunction and is reversible. Nature Neuroscience. 2018; 21:1404-1411.
Brief Report: A Double-Blind, Placebo-Controlled, Crossover, Proof-of-Concept Study of Minocycline in Autism Spectrum Disorder. Journal of Autism and Developmental Disorders. 2025; 55:3387-3394.
Hyper-extralemniscal model of Fragile X syndrome. Cerebral Cortex. 2025; 35:bhaf141.
Patterns in Medication Use for Treatment of Depression in Autistic Spectrum Disorder. Journal of Autism and Developmental Disorders. 2025; 55:1969-1975.
Frontal cortex hyperactivation and gamma desynchrony in Fragile X syndrome: Correlates of auditory hypersensitivity. PloS one. 2025; 20:e0306157.
Probing the Neurodynamic Mechanisms of Cognitive Flexibility in Depressed Individuals with Autism Spectrum Disorder. Journal of Child and Adolescent Psychopharmacology. 2025; 35:231-243.
Results from a Double-Blind, Randomized, Placebo-Controlled, Single-Dose, Crossover Trial of Lovastatin or Minocycline in Fragile X Syndrome. Journal of Child and Adolescent Psychopharmacology. 2025; 35:211-221.
Accelerated Theta Burst Transcranial Magnetic Stimulation for Refractory Depression in Autism Spectrum Disorder. Journal of Autism and Developmental Disorders. 2025; 55:940-954.
Computer Vision Based Neurology Brain Activity Rejection Architecture and Implementation. (2024) Institute of Electrical and Electronics Engineers (IEEE). 00:1481-1487.
Specialization of the brain for language in children with Fragile X Syndrome: a functional Near Infrared Spectroscopy study. Journal of Neurodevelopmental Disorders. 2024; 16:69.
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