John P. Pestian, PhD, MBA

Director, Computational Medicine Center

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-1627

Fax 513-636-2056


Dr. John Pestian is a professor of pediatrics, psychiatry, and biomedical informatics at Cincinnati Children's Hospital Medical Center within the University of Cincinnati. The mission of the Pestian Lab is to develop advanced technology for the care of neuropsychiatric illness. The lab does this by teaching computers to understand the dimensions of neuropsychiatric diagnosis and treatment by integrating genetics, language, voice and facial features to developing advance multi-modal analytical tools.

Dr. Pestian is the founding director of Cincinnati Children’s Division of Biomedical Informatics. He established the Computational Medicine Center with a $28 million grant from Ohio's Third Frontier Project. Ultimately, this effort led to the creation of over 500 high-tech jobs and collaborating on over $190 million in grants. He has an extensive publication and patent portfolio. One patent where he is co-inventor has been used to identify personalized neuropsychiatric medications for over 215,000 people. He is a entrepreneur who has worked with Cincinnati Children’s and CincyTech start-up experts to create companies dedicated to disseminating knowledge through the market place.

BS: St. Francis College, Loreto, PA, 1981.

MA: University of Steubenville, Steubenville, OH, 1987.

PhD: Virginia Commonwealth University, Richmond, VA, 1994.

View Publications on Google Scholar

Sánchez Fernández I, Abend NS, Agadi S, An S, Arya R, Carpenter JL, Chapman KE, Gaillard WD, Glauser TA, Goldstein DB, Goldstein JL, Goodkin HP, Hahn CD, Heinzen EL, Mikati MA, Peariso K, Pestian JP, Ream M, Riviello JJ Jr, Tasker RC, Williams K, Loddenkemper T; Pediatric Status Epilepticus Research Group (pSERG). Gaps and opportunities in refractory status epilepticus research in children: a multi-center approach by the Pediatric Status Epilepticus Research Group (pSERG). Seizure. 2014 Feb;23(2):87-97.

Pestian JP, Grupp-Phelan J, Bretonnel Cohen K, Meyers G, Richey LA, Matykiewicz P, Sorter MT. A Controlled Trial Using Natural Language Processing to Examine the Language of Suicidal Adolescents in the Emergency Department. Suicide Life Threat Behav. 2015 Aug 7.

Shinnar S, Cnaan A, Hu F, Clark P, Dlugos D, Hirtz DG, Masur D, Mizrahi EM, Moshé SL, Glauser TA; Childhood Absence Epilepsy Study Group. Long-term outcomes of generalized tonic-clonic seizures in a childhood absence epilepsy trial. Neurology. 2015 Sep 29;85(13):1108-14.

Pestian JP. Computational semantics in clinical text supplement. Biomed Inform Insights. 2013 Jun 24;6(Suppl 1):1-2.

Pestian JP, Matykiewicz P, Linn-Gust M. What's In a Note: Construction of a Suicide Note Corpus. Biomed Inform Insights. 2012;5:1-6.

Glauser TA, Cnaan A, Shinnar S, Hirtz DG, Dlugos D, Masur D, Clark PO, Adamson PC; Childhood Absence Epilepsy Study Team. Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy: initial monotherapy outcomes at 12 months. Epilepsia. 2013 Jan;54(1):141-55.

Pestian JP. Introductory editorial. Biomed Inform Insights. 2012;5(Suppl. 1):1.

Pestian JP, Matykiewicz P, Linn-Gust M, South B, Uzuner O, Wiebe J, Cohen KB,  Hurdle J, Brew C. Sentiment Analysis of Suicide Notes: A Shared Task. Biomed Inform Insights. 2012 Jan 30;5(Suppl 1):3-16.

Pestian JP, Matykiewicz P, Grupp-Phelan J, Lavanier SA, Combs J, Kowatch R. Using natural language processing to classify suicide notes. AMIA Annu Symp Proc. 2008 Nov 6:1091.

Wade SL, Wolfe C, Brown TM, Pestian JP. Putting the pieces together: preliminary efficacy of a web-based family intervention for children with traumatic brain injury. J Pediatr Psychol. 2005 Jul-Aug;30(5):437-42.