Joo-Seop Park, PhD, is an associate professor in the Divisions of Pediatric Urology and Developmental Biology at Cincinnati Children's Hospital Medical Center. He received his bachelor's in pharmacy from Seoul National University in Seoul, South Korea. He subsequently studied the regulation of gene transcription with Dr. Jeffrey W. Roberts at Cornell University in Ithaca, NY where he obtained his doctorate in molecular biology and genetics in 2004. Dr. Park then went on to postdoctoral training with Dr. Andrew P. McMahon at Harvard University where he was awarded fellowships from the National Kidney Foundation and the Charles King Trust to study mammalian kidney development.
Dr. Park is interested in understanding how progenitor cells maintain their multi-potent status and how they differentiate into different types of cells during organogenesis of the mammalian kidney and bladder. His lab studies transcriptional and epigenetic controls of cis-regulatory modules that act downstream of various signaling pathways.
Kidney development; nephron segmentation; proximal tubules
Urology, Developmental Biology
Hnf4a deletion in the mouse kidney phenocopies Fanconi renotubular syndrome. JCI insight. 2018; 3.
Notch is required for the formation of all nephron segments and primes nephron progenitors for differentiation. Development (Cambridge). 2017; 144:4530-4539.
Transcriptional Regulation by ATOH1 and its Target SPDEF in the Intestine. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2017; 3:51-71.
Notch signaling promotes nephrogenesis by downregulating Six2. Development (Cambridge). 2016; 143:3907-3913.
Single cell dissection of early kidney development: multilineage priming. Development (Cambridge). 2014; 141:3093-3101.
Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis. Development (Cambridge). 2014; 141:1442-1452.
Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks. Developmental Cell. 2012; 23:637-651.
Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development. Development (Cambridge). 2007; 134:2533-2539.
Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Developmental Cell. 2005; 9:283-292.