Manoj K. Pandey, PhD

Academic Affiliations

Instructor, UC Department of Pediatrics

Phone 513-803-1694

Email manoj.pandey@cchmc.org

Clinical

Immunology

Research

Lipid arbitrated autoantibodies, complement activation products, and cytokines comebacks in several lysosomal storage and rare genetic diseases.

Visit the Pandey Lab.

Dr. Manoj Pandey is a principal investigator in the Division of Human Genetics at Cincinnati Children's Hospital Medical Center. Dr. Pandey earned his PhD in the topic “Maternal Immunoregulation and Fetal Survival” from the Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, India. He completed his post-doctoral trainings from Mayo Clinic, Rochester, MN and Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Dr. Pandey is a member of the American Association of Immunology, Neurology, and Genetics. The mainstream of Dr. Pandey’s research investigates the mechanisms by which immune system responses to complex lipid and protein challenges and fuels the visceral and brain inflammation in rare lysosomal storage, neurodegenerative, and genetic diseases. Based on this knowledge Dr Pandey is leading a team of researchers and clinicians for developing novel therapeutic approaches to prevent the disease process in Gaucher, Parkinson and other LSDs.

PhD: Sanjay Gandhi Post Graduate Institute of Medical Sciences, India, 2003.

Post Doc: Molecular Medicine Program, Mayo Clinic, Rochester, MN; Division of Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2004-2008.

Pandey MK, Grabowski GA, Köhl J. An unexpected player in Gaucher disease: The multiple roles of complement in disease development. Semin Immunol. 2018;S1044-5323(17):30104-5.

Pandey MK, Burrow TA, Rani R, Martin LJ, Witte D, Setchell KD, McKay MA, Magnusen AF, Zhang W, Liou B, Köhl J, Grabowski GA. Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease. Nature. 2017;543:108-112.

Pandey MK , Nicholas JA, Xu Y, Zhang W, Setchell K, Grabowski GA. Gaucher Disease: Chemotactic factors and immunological cell invasion in a mouse model.  Mol Genet Metab 2014, 111(2): 163-171.

Pandey MK.  Molecular Basis for Downregulation of C5a-Mediated Inflammation by IgG1 Immune Complexes in Allergy and Asthma. Curr Allergy Asthma Rep 2013; 2013(6): 596-606.

Pandey, MK., Grabowski GA. Immunological cells and functions in Gaucher disease. Crit Revi Onco 2013, 18(3): 197–220.

Karsten CM*, Pandey MK*, Figge J, Taylor PR, McDonald JU, Strait RT, Harris NL, Koehl G, Brown GD, Finkelman FD, Koehl J. Galactosylated IgG1 links FcγRIIB and Dectin-1 to block complement-mediated inflammation. Nat Med 2012,18(9):1401-1406. *shared first authorship.

Pandey MK, Rani R, Zhang W, Setchell K, Grabowski GA. Immunological cell type characterization and Th1-Th17 cytokine production in a mouse model of Gaucher disease. Mol Genet Metab 2012, 106:310-322.

Bestebroer J, Aerts PC, Rooijakkers SH, Pandey MK , Köhl J, van Strijp JA, de Haas CJ. Functional basis for complement evasion by staphylococcal superantigen-like7.  Cell Microbiol 2010, 12(10): 1506–1516.

Jongerius I, Köhl J, Pandey MK, Ruyken M, Van Kessel KPM, Van Strijp JAG, Rooijakkers SHM. Staphylococcal complement evasion by various convertase-blocking molecules.  J Exp Med 2007, 204(10): 2461-2471.

Kohl J, Balder R, Lewkowish I, Pandey MK , Hawlisch H, Wang L, Herman N, Best J, Zwirner J, Whitsett JA, Lambns JD, Paul R, Schmitz-Perreira S, Scharfstein J, Wills-Karp M.A. Regulatory role for the C5a anaphylatoxin on type 2 immunity in asthma . J Clin Invest 2006, 16 (3):783-796.