A photo of Manoj Pandey.

Instructor, UC Department of Pediatrics

513-803-1694

Biography & Affiliation

Biography

Dr. Manoj Pandey is a principal investigator in the Division of Human Genetics at Cincinnati Children's Hospital Medical Center. Dr. Pandey earned his PhD in the topic “Maternal Immunoregulation and Fetal Survival” from the Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, India. He completed his post-doctoral trainings from Mayo Clinic, Rochester, MN and Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Dr. Pandey is a member of the American Association of Immunology, Neurology, and Genetics. The mainstream of Dr. Pandey’s research investigates the mechanisms by which immune system responses to complex lipid and protein challenges and fuels the visceral and brain inflammation in rare lysosomal storage, neurodegenerative, and genetic diseases. Based on this knowledge Dr Pandey is leading a team of researchers and clinicians for developing novel therapeutic approaches to prevent the disease process in Gaucher, Parkinson and other LSDs.

Clinical Interests

Immunology

Research Interests

Lipid arbitrated autoantibodies, complement activation products, and cytokines comebacks in several lysosomal storage and rare genetic diseases.

Academic Affiliation

Instructor, UC Department of Pediatrics

Department

Human Genetics

Science Blog

Education

PhD: Sanjay Gandhi Post Graduate Institute of Medical Sciences, India, 2003.

Post Doc: Molecular Medicine Program, Mayo Clinic, Rochester, MN; Division of Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2004-2008.

Publications

Hypoxia-induced Pulmonary Hypertension in Different Mouse Strains: Relation to Transcriptome. Ikeda, KT; Hale, PT; Pauciulo, MW; Dasgupta, N; Pastura, PA; Le Cras, TD; Pandey, MK; Nichols, WC. American Journal of Respiratory Cell and Molecular Biology. 2019; 60:106-116.

An unexpected player in Gaucher disease: The multiple roles of complement in disease development. Pandey, MK; Grabowski, GA; Koehl, J. Seminars in Immunology. 2018; 37:30-42.

Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease. Pandey, MK; Burrow, TA; Rani, R; Martin, LJ; Witte, D; Setchell, KD; Mckay, MA; Magnusen, AF; Zhang, W; Liou, B; et al. Nature. 2017; 543:108-112.

Neuronopathic Gaucher disease: dysregulated mRNAs and miRNAs in brain pathogenesis and effects of pharmacologic chaperone treatment in a mouse model. Dasgupta, N; Xu, Y; Li, R; Peng, Y; Pandey, MK; Tinch, SL; Liou, B; Inskeep, V; Zhang, W; Setchell, KD R; et al. Human Molecular Genetics. 2015; 24:ddv404-ddv404.