A photo of Mihaela Pavlicev.

Assistant Professor, UC Department of Pediatrics

Biography & Affiliation

Biography

Dr. Pavlicev received a PhD in ecology from the University of Vienna in 2003. After PhD she trained in molecular phylogenetics at the Natural History Museum in Vienna, primarily working on phylogenetics of lizards and birds. During subsequent postdoctoral training in quantitative genetics, she worked on the structure and evolution of the genotype-to-phenotype map, first at Washington University in St. Louis, and later at the Center for Ecological and Evolutionary Synthesis at the University of Oslo, Norway. She subsequently spent a year at Konrad Lorenz Institute for Evolution and Cognition in Altenberg near Vienna and combined writing with teaching at the Department of Theoretical Biology, University of Vienna. She joined faculty at Cincinnati Children’s in the summer of 2013.

Dr. Pavlicev`s work focuses on understanding the patterns of phenotypic variation and its underlying genetics in the context of past evolution (see Publications). These approaches have fairly recently become used to understand human detrimental variation, i.e., disease, in a field commonly referred to as evolutionary medicine. Dr. Pavlicev`s lab focuses on the evolution of female reproduction and specifically pregnancy, in order to address the causes for the prevalence of premature births in human population.

Research Interests

The structure of genotype-phenotype map; evolutionary history of female reproductive biology

Academic Affiliation

Assistant Professor, UC Department of Pediatrics

Departments

Neonatology, Prevention of Preterm Birth, Human Genetics

Education

PhD: University of Vienna, Austria, 2003.

Postdoc: Washington University St. Louis (with Jim Cheverud), University of Oslo (with Thomas Hansen).

Publications

Selected Publication

Predicting evolutionary potential: A numerical test of evolvability measures. Hansen, TF; Solvin, TM; Pavlicev, M. Evolution. 2019; 73:689-703.

Female orgasm and the emergence of prosocial empathy: An evo-devo perspective. Kennedy, J; Pavlicev, M. Journal of Experimental Zoology. Part B: Molecular and Developmental Evolution. 2018; 330:66-75.

Human Parturition: Nothing More Than a Delayed Menstruation. Pavlicev, M; Norwitz, ER. Reproductive Sciences. 2018; 25:166-173.

Origin, Function, and Effects of Female Orgasm: All Three are Different. Wagner, GP; Pavlicev, M. Journal of Experimental Zoology. Part B: Molecular and Developmental Evolution. 2017; 328:299-303.

Single-cell transcriptomics of the human placenta: inferring the cell communication network of the maternal-fetal interface. Pavlicev, M; Wagner, GP; Chavan, AR; Owens, K; Maziarz, J; Dunn-Fletcher, C; Kallapur, SG; Muglia, L; Jones, H. Genome Research. 2017; 27:349-361.

Cliff-edge model of obstetric selection in humans. Mitteroecker, P; Huttegger, SM; Fischer, B; Pavlicev, M. Proceedings of the National Academy of Sciences of USA. 2016; 113:14680-14685.

Development Shapes a Consistent Inbreeding Effect in Mouse Crania of Different Line Crosses. Pavlicev, M; Mitteroecker, P; Gonzalez, PM; Rolian, C; Jamniczky, H; Villena, FP-M; Marcucio, R; Spritz, R; Hallgrimsson, B. Journal of Experimental Zoology. Part B: Molecular and Developmental Evolution. 2016; 326:474-488.

The origin and evolution of cell types. Arendt, D; Musser, JM; Baker, CV H; Bergman, A; Cepko, C; Erwin, DH; Pavlicev, M; Schlosser, G; Widder, S; Laubichler, MD; et al. Nature Reviews: Genetics. 2016; 17:744-757.

What the Evolution of Female Orgasm Teaches Us. Wagner, GP; Pavlicev, M. Journal of Experimental Zoology. Part B: Molecular and Developmental Evolution. 2016; 326:325-325.

The Evolutionary Origin of Female Orgasm. Pavlicev, M; Wagner, G. Journal of Experimental Zoology. Part B: Molecular and Developmental Evolution. 2016; 326:326-337.