Mihaela Pavlicev, PhD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

The structure of genotype-phenotype map; evolutionary history of female reproductive biology

Visit the Pavlicev Lab.

Dr. Pavlicev received a PhD in ecology from the University of Vienna in 2003. After PhD she trained in molecular phylogenetics at the Natural History Museum in Vienna, primarily working on phylogenetics of lizards and birds. During subsequent postdoctoral training in quantitative genetics, she worked on the structure and evolution of the genotype-to-phenotype map, first at Washington University in St. Louis, and later at the Center for Ecological and Evolutionary Synthesis at the University of Oslo, Norway. She subsequently spent a year at Konrad Lorenz Institute for Evolution and Cognition in Altenberg near Vienna and combined writing with teaching at the Department of Theoretical Biology, University of Vienna. She joined faculty at Cincinnati Children’s in the summer of 2013.

Dr. Pavlicev`s work focuses on understanding the patterns of phenotypic variation and its underlying genetics in the context of past evolution (see Publications). These approaches have fairly recently become used to understand human detrimental variation, i.e., disease, in a field commonly referred to as evolutionary medicine. Dr. Pavlicev`s lab focuses on the evolution of female reproduction and specifically pregnancy, in order to address the causes for the prevalence of premature births in human population.

PhD: University of Vienna, Austria, 2003.

Postdoc: Washington University St. Louis (with Jim Cheverud), University of Oslo (with Thomas Hansen).

View PubMed Publications

Arendt D, Musser JM, Baker CVH, Bergman A, Cepko C, Erwin DH, Pavličev M, Schlosser G, Widder S, Laubichler MD, Wagner GP. Evolution of sister cell types by individuation. Nature Reviews Genetics. 2016.

Kin K, Maziarz J, Chavan AR, Kamat M, Vasudevan S, Emera D, Lynch V, Ott T, Pavličev M, Wagner GP. The transcriptomic evolution of mammalian pregnancy: gene expression innovations in endometrial stromal fibroblasts. Genome biology and evolution. 2016.

Pavličev M, Wagner GP. The evolutionary origin of female orgasm. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution. 2016.

Eidem HR, Rinker DC, Ackerman WE, Buhimschi IA, Buhimschi CS, Dunn-Fletcher C, Kallapur SG, Pavličev M, Muglia LJ, Abbot P, Rokas A. Comparing human and macaque placental transcriptomes to disentangle preterm birth pathology from gestational age effects. Placenta. 2016;41:74-82.

Mitteroecker P, Cheverud JM, Pavličev M. Multivariate Analysis of Genotype–Phenotype Association. Genetics. 2016;202(4):1345-1363.

Pavličev M, Cheverud JM. Constraints Evolve: Context-Dependency of Gene Effects Allows Evolution of Pleiotropy. Annual Review of Ecology, Evolution, and Systematics. 2015;46(1).

Pavličev M, Widder S. Wiring for independence: Positive feedback motifs facilitate individuation of traits in development and evolution. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution. 2015;324(2): 104-113.

Pavličev M, Hiratsuka K, Swaggart KA, Dunn C, Muglia LJ. Detecting endogenous retrovirus-driven tissue-specific gene transcription. Genome biology and evolution. 2015;7(4):1082-1097.

Swaggart K, Pavličev M, Muglia LJ. Genomics of Preterm Birth. In: Perspective on Human Reproductive and Newborn Medicine, ed: Norwitz E, Bianchi D. Cold Spring Harbor Perspective. 2015.

Wagner GP, Kin K, Muglia L, Pavličev M. Evolution of mammalian pregnancy and the origin of the decidual stromal cell. International Journal of Developmental Biology. 2013;58(2-3-4):117-126.