A photo of Amelle Shillington.

Amelle L. Shillington, DO

  • Attending Physician, Division of Human Genetics
  • Associate Program Director, Medical Genetics and Genomics Residencies
  • Assistant Professor, UC Department of Pediatrics


Residency: Combined Pediatric Medical Genetics, Cincinnati Children’s Hospital, Cincinnati, OH, 2017-2021.

DO: University of North Texas, Fort Worth, TX, 2017.

BA: Psychology with Honors, University of Waterloo, Canada, 1996-2000.


Autism spectrum disorder; intellectual disability; neurodevelopmental disorders; psychiatric genetics

Services and Specialties



Mendelian neurodevelopmental disorders; neurodevelopmental new gene discovery; psychiatric genetics; catatonia; autism; intellectual disability

Insurance Information

Cincinnati Children's strives to accept a wide variety of health plans. Please contact your health insurance carrier to verify coverage for your specific benefit plan.

View Insurance Information


Non-canonical C-terminal variant of MeCP2 R344W exhibits enhanced degradation rate. Chai, Y; Lee, SS Y; Shillington, A; Du, X; Fok, CK M; Yeung, KC; Siu, GK Y; Yuan, S; Zheng, Z; Tsang, HW S; et al. IBRO Neuroscience Reports. 2023; 15:218-224.

Genetic syndromes are prevalent in patients with comorbid neurodevelopmental disorders and catatonia. Shillington, A; Zappia, KJ; White, L; Fosdick, C; Erickson, CA; Lamy, M; Dominick, KC. American Journal of Medical Genetics, Part A. 2023; 191:2716-2722.

Elucidating the clinical and molecular spectrum of SMARCC2-associated NDD in a cohort of 65 affected individuals. Bosch, E; Popp, B; Güse, E; Skinner, C; van der Sluijs, PJ; Maystadt, I; Pinto, AM; Renieri, A; Bruno, LP; Granata, S; et al. Genetics in Medicine. 2023; 25:100950.

27.4 Catatonia in Neurodevelopmental Disorders and the Creation of a Neurobehavioral Catatonia Specialty Clinic. Dominick, KC; Zappia, K; Shillington, A; Fosdick, CM; Lamy, M; Erickson, CA. Journal of the American Academy of Child and Adolescent Psychiatry. 2023; 62:s366-s367.

Novel Pathogenic DNAH5 Variants in Primary Ciliary Dyskinesia: Association with Visceral Heterotaxia and Neonatal Cholestasis. Lin, HT; Gupta, A; Bove, KE; Szabo, S; Xu, F; Krentz, A; Shillington, AL. Journal of Pediatric Genetics. 2023; 12:246-253.

A novel RYR1 variant in an infant with a unique fetal presentation of central core disease. Baker, EK; Al Gharaibeh, FN; Bove, K; Calvo-Garcia, MA; Shillington, A; VandenHeuvel, K; Cortezzo, DM E. American Journal of Medical Genetics, Part A. 2023; 191:1646-1651.

Consolidation of the clinical and genetic definition of a SOX4-related neurodevelopmental syndrome. Angelozzi, M; Karvande, A; Molin, AN; Ritter, AL; Leonard, JM M; Savatt, JM; Douglass, K; Myers, SM; Grippa, M; Tolchin, D; et al. Journal of medical genetics. 2022; 59:1058-1068.

Familial Brain Calcifications With Leukoencephalopathy: A Novel PDGFB Variant. Shen, J; Shillington, A; Espay, AJ; Hill, EJ. Neurology: Genetics. 2022; 8:e200001.

A Collaborative Psychiatric-Genetics Inpatient Care Delivery Model Improves Access to Clinical Genetic Evaluation, Testing, and Diagnosis for Patients With Neurodevelopmental Disorders. Shillington, A; Lamy, M; Dominick, KC; Sorter, M; Erickson, CA; Hopkin, R. Frontiers in Genetics. 2022; 13:901458.

ZMYND11 variants are a novel cause of centrotemporal and generalised epilepsies with neurodevelopmental disorder. Oates, S; Absoud, M; Goyal, S; Bayley, S; Baulcomb, J; Sims, A; Riddett, A; Allis, K; Brasch-Andersen, C; Balasubramanian, M; et al. Clinical Genetics: an international journal of genetics and molecular medicine. 2021; 100:412-429.

From the Blog

‘Medical Mystery’: Cincinnati Children’s Diagnoses Child With Tango2
Genomics and Development

‘Medical Mystery’: Cincinnati Children’s Diagnoses Child With Tango2

Amelle L. Shillington, DO3/24/2022

Patient Ratings and Comments

All patient satisfaction ratings and comments are submitted by actual patients and verified by a leading independent patient satisfaction company, NRC Health. Patient identities are withheld to ensure confidentiality and privacy. Only those providers whose satisfaction surveys are administered through Cincinnati Children’s Hospital Medical Center are displayed. Click here to learn more about our survey

Overall Patient Rating