Daniel T. Starczynowski, PhD

Katherine Stewart Waters Endowed Chair of Hematologic Malignancies
Director, Advanced Leukemia Therapies and Research Center
Associate Director for Basic Sciences, UC Cancer Center
Institute Associate Director, Cancer and Blood Diseases Institute
Co-Chief Scientific Officer, Innovations Ventures
Co-Leader, Hematologic Malignancies Program
Member, Division of Experimental Hematology and Cancer Biology
Professor, UC Department of Pediatrics

daniel.starczynowski@cchmc.org

About

Biography

Daniel T. Starczynowski, PhD, received his PhD in molecular biology from Boston University. He studied the NF-kB family of transcription factors and their role in B-cell lymphomas. During his postdoctoral fellowship at the BC Cancer Research Center, Dr. Starczynowski identified and characterized novel candidate genes in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML).

Following his postdoctoral training, Dr. Starczynowski joined the faculty at Cincinnati Children’s Hospital Medical Center and at the University of Cincinnati as an Assistant Professor. Dr. Starczynowski’s laboratory investigates the molecular and cellular basis of hematologic malignancies with the goal to advance novel therapeutic strategies.

BS: Fairleigh Dickinson University, Teaneck, NJ, 2000.

PhD: Boston University, Boston, MA, 2006.

Postdoctoral Fellow: University of British Columbia/BC Cancer Research Centre, Vancouver, Canada, 2010.

Services and Specialties

Research Areas

Publications

Scaffolding-dependent CASP1 constrains excessive cell-intrinsic inflammatory signaling in leukemia. Uible, EE; Choi, I; Clough, CA; Hassan, A; Anandappa, AJ; Fisher, J; Karki, B; Hueneman, K; Choi, K; Vick, EJ; Pasare, C; Cunningham, JT; Volk, AG; Starczynowski, DT. Cell Chemical Biology. 2026.

Optimization of IRAK1/4/pan-FLT3 kinase inhibitors as treatments for acute myeloid leukemia. Sutter, PJ; Walker, MM; Finocchio, CJ; Jiang, J-K; Tawa, GJ; Zhang, X; Xu, X; Shah, P; Gomba, GY; Starczynowski, DT; Thomas, CJ; Hoyt, S. Bioorganic and Medicinal Chemistry Letters. 2025; 129:130355.

MICRO-TAG enzyme complementation enables quantification of cellular drug-target engagement in temperature series. Babic, I; Bryan, N; Cunningham, C; Sampson, A; Starczynowski, D; Nurmemmedov, E. SLAS Discovery. 2025; 38:100291.

FLT3-F691L confers kinase-independent resistance via Grb2-dependent MAPK signaling in AML. Jones, L; Khadaroo, A; Tiwari, R; Choi, K; Adam, M; Wunderlich, M; Stillwell, C; Sexton, C; Seibel, W; Tawa, G; Hoyt, S; Thomas, C; Starczynowski, D. Blood. 2025; 146(Supplement 1):5049-5049.

RAS G12 and Q61 codon mutations confer distinct disease characteristics in Acute Myeloid Leukemia and exhibit differential response to RAS(ON) inhibitor RMC-7977. Anandappa, A; Trivedi, V; Bones, M; Raval, J; Hefner, R; Wooten, A; Bowman, R; Levine, R; Starczynowski, D; Miles, L. Blood. 2025; 146(Supplement 1):3229-3229.

IRAK signaling in cancers: mechanisms, targeting, and clinical implications. Vick, EJ; Starczynowski, DT. Expert Opinion on Investigational Drugs. 2025; 34(10):775-792.

Targeting of IRAK4 and GSPT1 enhances therapeutic efficacy in AML via c-Myc destabilization. Vick, EJ; Hassan, A; Choi, K; Bennett, J; Muto, T; Clough, CA; Culver-Cochran, AE; Hueneman, K; Bolanos, LC; Wunderlich, M; Klumpp-Thomas, C; Greis, KD; Thomas, CJ; Starczynowski, DT. Leukemia. 2025; 39(9):2163-2173.

Characterization of E1 enzyme dependencies in mutant-UBA1 human cells reveals UBA6 as a novel therapeutic target in VEXAS syndrome. Clough, CA; Cunningham, C; Philbrook, SY; Hueneman, KM; Sampson, AM; Choi, K; Greis, KD; Starczynowski, D. Leukemia. 2025; 39(8):1997-2009.

Integrated cytogenetic and genomic profiling of the MDS-L cell line. Mestre, J; Chaparro-González, L; Granada, I; Mallo, M; Cid, E; Mancini, E; Calvete, O; Risueño, RM; Starczynowski, DT; Solé, F. Molecular Cytogenetics. 2025; 18(1):11.

Microbial metabolite drives ageing-related clonal haematopoiesis via ALPK1. Agarwal, P; Sampson, A; Hueneman, K; Choi, K; Jakobsen, NA; Uible, E; Ishikawa, C; Yeung, J; Bolanos, L; Zhao, X; Galloway-Pena, J; Byrd, JC; Vyas, P; Starczynowski, DT. Nature. 2025; 642(8066):201-211.