A photo of Juan Sanchez Gurmaches.

Assistant Professor, UC Department of Pediatrics


Biography & Affiliation

Research Interests

Adipocytes; brown and white fat; animal models; adipocyte development and heterogeneity; insulin signaling; animal models

Academic Affiliation

Assistant Professor, UC Department of Pediatrics


Endocrinology, Developmental Biology


BS: University of Barcelona, Catalunya, Spain, 2005.

PhD: University of Barcelona, Catalunya, Spain, 2010.


Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1. Jung, SM; Hung, C; Hildebrand, SR; Sanchez-Gurmaches, J; Martinez-Pastor, B; Gengatharan, JM; Wallace, M; Mukhopadhyay, D; Calejman, CM; Luciano, AK; et al. Molecular Cell. 2019; 75:807-822.e8.

Inflammation and Immunity: From an Adipocyte's Perspective. Chan, CC; Damen, MS M A; Alarcon, PC; Sanchez-Gurmaches, J; Divanovic, S. Journal of Interferon and Cytokine Research. 2019; 39:459-471.

A Brain-Melanocortin-Vagus Axis Mediates Adipose Tissue Expansion Independently of Energy Intake. Holland, J; Sorrell, J; Yates, E; Smith, K; Arbabi, S; Arnold, M; River, M; Morano, R; Chen, J; Zhang, X; et al. Cell Reports. 2019; 27:2399-2410.e6.

Brown fat organogenesis and maintenance requires AKT1 and AKT2. Sanchez-Gurmaches, J; Calejman, CM; Jung, SM; Li, H; Guertin, DA. Molecular Metabolism. 2019; 23:60-74.

Brown adipose tissue development and metabolism. Jung, SM; Sanchez-Gurmaches, J; Guertin, DA. Handbook of Experimental Pharmacology. 2019; 251:3-36.

Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues. Wallace, M; Green, CR; Roberts, LS; Lee, YM; McCarville, JL; Sanchez-Gurmaches, J; Meurs, N; Gengatharan, JM; Hover, JD; Phillips, SA; et al. Nature Chemical Biology. 2018; 14:1021-1031.

Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis. Sanchez-Gurmaches, J; Tang, Y; Jespersen, NZ; Wallace, M; Calejman, CM; Gujja, S; Li, H; Edwards, YJ K; Wolfrum, C; Metallo, CM; et al. Cell Metabolism. 2018; 27:195-209.e6.

Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism. Tang, Y; Wallace, M; Sanchez-Gurmaches, J; Hsiao, W; Li, H; Lee, PL; Vernia, S; Metallo, CM; Guertin, DA. Nature Communications. 2016; 7.

Emerging Complexities in Adipocyte Origins and Identity. Sanchez-Gurmaches, J; Hung, C; Guertin, DA. Trends in Cell Biology. 2016; 26:313-326.

Highly Selective In Vivo Labeling of Subcutaneous White Adipocyte Precursors with Prx1-Cre. Sanchez-Gurmaches, J; Hsiao, W; Guertin, DA. Stem Cell Reports. 2015; 4:541-550.