Obesity is one of the principal risk factors for metabolic dysregulations, including type 2 diabetes, as well as cardiovascular disease and stroke. Therefore, obesity creates incredible emotional, health and economic burdens worldwide. We are in desperate need of new therapies to reduce or reverse the effects of obesity. The long-term objective of our research program is to elucidate the developmental and metabolic mechanisms that control adipocyte functions. To address this goal, we are combining the strengths of mouse and human genetics, genome engineering tools, innovative lineage tracing techniques that allow single-cell resolution, genomics, metabolomics and metabolite tracing, cell biology, and biochemical techniques.