Mathieu performed his PhD research at the National Institute of Health and Medical Research in the Division of Immunology and Genetics of Parasitic Diseases in Marseille (France). While there, he studied the human immune response to schistosomiasis, and genetic susceptibility to severe forms of the disease (liver fibrosis).
In 2012, Mathieu moved to Cincinnati Children's Hospital Medical Center to explore hematopoietic stem cell and immune deficiencies in the childhood disorder Fanconi anemia disease in the laboratory of Dr. Qishen Pang. His work demonstrated:
- The deregulation of WNT signaling in Fanconi deficient B cells leads to an impairment of cellular differentiation into plasma cells.
- The deleterious effect of Pparg activity on hematopoietic stem cells self-renewal and maintenance under stress conditions.
In 2015 Mathieu moved to the laboratory of Dr. Susanne Wells to spearhead basic research studies in the new Proton Therapy Center in collaboration with the Heidelberg Ion Beam Therapy Center (HIT, Germany, and Dr. Amir Abdollahi).
In 2019 Mathieu was appointed director of the Proton and Radiation research core in the Cincinnati Children's oncology department after setting up and developing the research activity at the Cincinnati Children's Proton center.
His research is focused on the specific biological and molecular responses to particle radiation therapy and to define new particle therapy sensitizer for cancer treatment. Precise dose delivery makes proton therapy a preferred approach of irradiation for healthy tissue sparing during cancer treatment. This is particularly relevant for childhood cancer and patients with inherited susceptibility to DNA damaging agents. Despite the use of particle therapy in the clinic, little is known about the biological response especially when compared to the conventional X-ray therapy. His research is aimed to determine differential cancer and normal tissue responses to particle therapy in comparison to X-ray, to optimize clinical usage and develop combinatorial strategies for sensitizing tumors and improving outcome of particle therapy.
Pediatric oncology; particle therapy and radiotherapy; radiotherapy and drug combinatorial strategies development
Instructor, UC Department of Pediatrics