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Professor, UC Department of Pediatrics
nancy.sawtell@cchmc.org
513-636-7880
513-636-7655
Molecular mechanisms of herpes virus latency and reactivation; viral persistence; pathogenesis; animal models of disease
Infectious Diseases
Nancy M. Sawtell, PhD3/5/2020
BA: Chemistry, Case Western Reserve University, 1975.
PhD: Pathology and Immunology, University of Cincinnati Medical College, Cincinnati, OH, 1986.
Identification of surfactant proteolipid SP-B in human surfactant and fetal lung. WEAVER, TE; SARIN, VK; SAWTELL, N; HULL, WM; WHITSETT, JA. Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 1988; 65:982-987.
Alphaherpesvirus Latency and Reactivation with a Focus on Herpes Simplex Virus. Sawtell, NM; Thompson, RL. Current Issues in Molecular Biology. 2021; 41:267-356.
Resolution of herpes simplex virus reactivation in vivo results in neuronal destruction. Doll, JR; Hoebe, K; Thompson, RL; Sawtell, NM. PLoS Pathogens. 2020; 16.
HSV Mutant Generation and Dual Detection Methods for Gaining Insight into Latent/Lytic Cycles In Vivo. Sawtell, NM; Thompson, RL. Methods in Molecular Biology. 2020; 2060:219-239.
Alpha Herpesvirus Latency and Reactivation With a Focus on Herpes Simplex Virus. Sawtell, NM; Thompson, RL. Alphaherpesviruses: Molecular Biology, Host Interactions and Control. 2020.
Targeted Promoter Replacement Reveals That Herpes Simplex Virus Type-1 and 2 Specific VP16 Promoters Direct Distinct Rates of Entry Into the Lytic Program in Sensory Neurons in vivo. Thompson, RL; Sawtell, NM. Frontiers in Microbiology. 2019; 10.
Infectious Herpes Simplex Virus in the Brain Stem Is Correlated with Reactivation in the Trigeminal Ganglia. Doll, JR; Thompson, RL; Sawtell, NM. Journal of Virology. 2019; 93.
Promyelocytic leukemia (PML) nuclear bodies (NBs) induce latent/quiescent HSV-1 genomes chromatinization through a PML NB/Histone H3.3/H3.3 Chaperone Axis. Cohen, C; Corpet, A; Roubille, S; Maroui, MA; Poccardi, N; Rousseau, A; Kleijwegt, C; Binda, O; Texier, P; Sawtell, N; et al. PLoS Pathogens. 2018; 14.
Inferred father-to-son transmission of herpes simplex virus results in near-perfect preservation of viral genome identity and in vivo phenotypes. Pandey, U; Renner, DW; Thompson, RL; Szpara, ML; Sawtell, NM. Scientific Reports. 2017; 7.
Analysis of Herpes Simplex Virus Reactivation in Explant Reveals a Method-Dependent Difference in Measured Timing of Reactivation. Doll, JR; Sawtell, NM. Journal of Virology. 2017; 91.