A photo Nancy M. Sawtell.

Professor, UC Department of Pediatrics

513-636-7880

513-636-7655

Biography & Affiliation

Clinical Interests

Molecular mechanisms of herpes virus latency and reactivation; viral persistence; pathogenesis; animal models of disease

Academic Affiliation

Professor, UC Department of Pediatrics

Research Divisions

Infectious Diseases



Blog Posts

In Mice, Antiviral Appears to Block Brain Damage From Latent HSV Reactivation

Infectious Diseases and Vaccines

In Mice, Antiviral Appears to Block Brain Damage From Latent HSV Reactivation

Nancy M. Sawtell, PhD3/5/2020

Education

BA: Chemistry, Case Western Reserve University, 1975.

PhD: Pathology and Immunology, University of Cincinnati Medical College, Cincinnati, OH, 1986.

Publications

Selected Publication

IDENTIFICATION OF SURFACTANT PROTEOLIPID-SP-B IN HUMAN SURFACTANT AND FETAL LUNG. WEAVER, TE; SARIN, VK; SAWTELL, N; HULL, WM; WHITSETT, JA. Journal of applied physiology (Bethesda, Md. : 1985). 1988; 65:982-987.

Resolution of herpes simplex virus reactivation in vivo results in neuronal destruction. Doll, JR; Hoebe, K; Thompson, RL; Sawtell, NM. PLoS Pathogens. 2020; 16:e1008296-e1008296.

HSV Mutant Generation and Dual Detection Methods for Gaining Insight into Latent/Lytic Cycles In Vivo. Sawtell, NM; Thompson, RL. Methods in molecular biology (Clifton, N.J.). 2020; 2060:219-239.

Targeted Promoter Replacement Reveals That Herpes Simplex Virus Type-1 and 2 Specific VP16 Promoters Direct Distinct Rates of Entry Into the Lytic Program in Sensory Neurons in vivo. Thompson, RL; Sawtell, NM. Frontiers in Microbiology. 2019; 10.

Infectious Herpes Simplex Virus in the Brain Stem Is Correlated with Reactivation in the Trigeminal Ganglia. Doll, JR; Thompson, RL; Sawtell, NM. Journal of Virology. 2019; 93.

Promyelocytic leukemia (PML) nuclear bodies (NBs) induce latent/quiescent HSV-1 genomes chromatinization through a PML NB/Histone H3.3/H3.3 Chaperone Axis. Cohen, C; Corpet, A; Roubille, S; Maroui, MA; Poccardi, N; Rousseau, A; Kleijwegt, C; Binda, O; Texier, P; Sawtell, N; et al. PLoS Pathogens. 2018; 14:e1007313-e1007313.

Inferred father-to-son transmission of herpes simplex virus results in near-perfect preservation of viral genome identity and in vivo phenotypes. Pandey, U; Renner, DW; Thompson, RL; Szpara, ML; Sawtell, NM. Scientific Reports. 2017; 7.

Analysis of Herpes Simplex Virus Reactivation in Explant Reveals a Method-Dependent Difference in Measured Timing of Reactivation. Doll, JR; Sawtell, NM. Journal of Virology. 2017; 91.

De Novo Herpes Simplex Virus VP16 Expression Gates a Dynamic Programmatic Transition and Sets the Latent/Lytic Balance during Acute Infection in Trigeminal Ganglia. Sawtell, NM; Thompson, RL. PLoS Pathogens. 2016; 12:e1005877-e1005877.