A photo of Pranavkumar Shivakumar.

Assistant Professor, UC Department of Pediatrics



Biography & Affiliation

Research Interests

Dissecting molecular mechanisms and pathways involved in the pathogenesis of biliary atresia

Academic Affiliation

Assistant Professor, UC Department of Pediatrics

Research Divisions

Gastroenterology Hepatology and Nutrition

Blog Posts


PhD: University of Bombay, Bombay, India, 2002.

MPharm: University of Bombay, Bombay, India, 1997.


Selected Publication

Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells. Asai, A; Aihara, E; Watson, C; Mourya, R; Mizuochi, T; Shivakumar, P; Phelan, K; Mayhew, C; Helmrath, M; Takebe, T; et al. Development (Cambridge). 2017; 144:1056-1064.

Preferential TNFα signaling via TNFR2 regulates epithelial injury and duct obstruction in experimental biliary atresia. Shivakumar, P; Mizuochi, T; Mourya, R; Gutta, S; Yang, L; Luo, Z; Bezerra, JA. JCI insight. 2017; 2.

Biliary organoids uncover delayed epithelial development and barrier function in biliary atresia. Amarachintha, SP; Mourya, R; Ayabe, H; Yang, L; Luo, Z; Li, X; Thanekar, U; Shivakumar, P; Bezerra, JA. Hepatology. 2021.

"Complimenting the Complement ": Mechanistic Insights and Opportunities for Therapeutics in Hepatocellular Carcinoma. Malik, A; Thanekar, U; Amarachintha, S; Mourya, R; Nalluri, S; Bondoc, A; Shivakumar, P. Frontiers in Oncology. 2021; 10.

Recent developments in etiology and disease modeling of biliary atresia: a narrative review. Malik, A; Thanekar, U; Mourya, R; Shivakumar, P. Digestive medicine research.. 2020; 3.

Regulation of bile duct epithelial injury by hepatic CD71+ erythroid cells. Yang, L; Shivakumar, P; Kinder, J; Way, SS; Donnelly, B; Mourya, R; Luo, Z; Bezerra, JA. JCI insight. 2020; 5.

Gene Expression Signatures Associated With Survival Times of Pediatric Patients With Biliary Atresia Identify Potential Therapeutic Agents. Luo, Z; Shivakumar, P; Mourya, R; Gutta, S; Bezerra, JA. Gastroenterology. 2019; 157:1138-1152.e14.

Visualizing Structures in Confocal Microscopy Datasets Through Clusterization: A Case Study on Bile Ducts. Beltran, LA C; Cruz, CU; dos Santos, JL; Shivakumar, P; Bezerra, J; Freitas, CM D S; IEEE, . (2019) 00:405-410.

Single cell RNA sequencing reveals regional heterogeneity of hepatobiliary innate lymphoid cells in a tissue-enriched fashion. Peters, AL; Luo, Z; Li, J; Mourya, R; Wang, Y; Dexheimer, P; Shivakumar, P; Aronow, B; Bezerra, JA. PLoS ONE. 2019; 14.

Regulation of epithelial injury and bile duct obstruction by NLRP3, IL-1R1 in experimental biliary atresia. Yang, L; Mizuochi, T; Shivakumar, P; Mourya, R; Luo, Z; Gutta, S; Bezerra, JA. Journal of Hepatology. 2018; 69:1136-1144.