A photo of Pranavkumar Shivakumar.

Pranavkumar Shivakumar, PhD

  • Assistant Professor, UC Department of Pediatrics


PhD: University of Bombay, Bombay, India, 2002.

MPharm: University of Bombay, Bombay, India, 1997.


Dissecting molecular mechanisms and pathways involved in the pathogenesis of biliary atresia

Research Areas

Gastroenterology Hepatology and Nutrition



Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells. Asai, A; Aihara, E; Watson, C; Mourya, R; Mizuochi, T; Shivakumar, P; Phelan, K; Mayhew, C; Helmrath, M; Takebe, T; Wells, J; Bezerra, JA. Development (Cambridge). 2017; 144:1056-1064.


Preferential TNFα signaling via TNFR2 regulates epithelial injury and duct obstruction in experimental biliary atresia. Shivakumar, P; Mizuochi, T; Mourya, R; Gutta, S; Yang, L; Luo, Z; Bezerra, JA. JCI insight. 2017; 2:e88747.

Plasticity between type 2 innate lymphoid cell subsets and amphiregulin expression regulates epithelial repair in biliary atresia. Russi, AE; Shivakumar, P; Luo, Z; Bezerra, JA. Hepatology. 2023; 78:1035-1049.

Editorial: Infants with cholestasis. Uchida, H; Tiao, GM; Shivakumar, P; Wong, KK Y; Asai, A; Amano, H. Frontiers in Pediatrics. 2023; 11:1175231.

HIF-1alpha-pathway activation in cholangiocytes of patients with biliary atresia: An immunohistochemical/molecular exploratory study. Quelhas, P; Breton, MC; Oliveira, RC; Cipriano, MA; Teixeira, P; Cerski, CT; Shivakumar, P; Vieira, SM G; Kieling, CO; Verde, I; Santos, JL D. Journal of Pediatric Surgery. 2023; 58:587-594.

Maternal regulation of biliary disease in neonates via gut microbial metabolites. Jee, JJ; Yang, L; Shivakumar, P; Xu, PP; Mourya, R; Thanekar, U; Yu, P; Zhu, Y; Pan, Y; Wang, H; Luo, Z; Ollberding, NJ; Tang, ST; Bezerra, JA. Nature Communications. 2022; 13:18.

Serum Proteomics Uncovers Biomarkers of Clinical Portal Hypertension in Children With Biliary Atresia. Osborn, J; Mourya, R; Thanekar, U; Su, W; Fei, L; Shivakumar, P; Bezerra, JA. Hepatology Communications. 2022; 6:995-1004.

Biliary organoids uncover delayed epithelial development and barrier function in biliary atresia. Amarachintha, SP; Mourya, R; Ayabe, H; Yang, L; Luo, Z; Li, X; Thanekar, U; Shivakumar, P; Bezerra, JA. Hepatology. 2022; 75:89-103.

"Complimenting the Complement ": Mechanistic Insights and Opportunities for Therapeutics in Hepatocellular Carcinoma. Malik, A; Thanekar, U; Amarachintha, S; Mourya, R; Nalluri, S; Bondoc, A; Shivakumar, P. Frontiers in Oncology. 2021; 10:627701.

Recent developments in etiology and disease modeling of biliary atresia: a narrative review. Malik, A; Thanekar, U; Mourya, R; Shivakumar, P. Digestive medicine research.. 2020; 3:59.