A photo of Pranavkumar Shivakumar.

Pranavkumar Shivakumar, PhD

  • Assistant Professor, UC Department of Pediatrics




Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells. Asai, A; Aihara, E; Watson, C; Mourya, R; Mizuochi, T; Shivakumar, P; Phelan, K; Mayhew, C; Helmrath, M; Takebe, T; et al. Development (Cambridge). 2017; 144:1056-1064.


Preferential TNFα signaling via TNFR2 regulates epithelial injury and duct obstruction in experimental biliary atresia. Shivakumar, P; Mizuochi, T; Mourya, R; Gutta, S; Yang, L; Luo, Z; Bezerra, JA. JCI insight. 2017; 2.

HIF-1alpha-pathway activation in cholangiocytes of patients with biliary atresia: An immunohistochemical/molecular exploratory study. Quelhas, P; Breton, MC; Oliveira, RC; Cipriano, MA; Teixeira, P; Cerski, CT; Shivakumar, P; Vieira, SM G; Kieling, CO; Verde, I; et al. Journal of Pediatric Surgery. 2022.

Serum Proteomics Uncovers Biomarkers of Clinical Portal Hypertension in Children With Biliary Atresia. Osborn, J; Mourya, R; Thanekar, U; Su, W; Fei, L; Shivakumar, P; Bezerra, JA. Hepatology Communications. 2022; 6:995-1004.

Biliary organoids uncover delayed epithelial development and barrier function in biliary atresia. Amarachintha, SP; Mourya, R; Ayabe, H; Yang, L; Luo, Z; Li, X; Thanekar, U; Shivakumar, P; Bezerra, JA. Hepatology. 2022; 75:89-103.

"Complimenting the Complement ": Mechanistic Insights and Opportunities for Therapeutics in Hepatocellular Carcinoma. Malik, A; Thanekar, U; Amarachintha, S; Mourya, R; Nalluri, S; Bondoc, A; Shivakumar, P. Frontiers in Oncology. 2021; 10.

Recent developments in etiology and disease modeling of biliary atresia: a narrative review. Malik, A; Thanekar, U; Mourya, R; Shivakumar, P. Digestive medicine research.. 2020; 3.

Regulation of bile duct epithelial injury by hepatic CD71+ erythroid cells. Yang, L; Shivakumar, P; Kinder, J; Way, SS; Donnelly, B; Mourya, R; Luo, Z; Bezerra, JA. JCI insight. 2020; 5.

Gene Expression Signatures Associated With Survival Times of Pediatric Patients With Biliary Atresia Identify Potential Therapeutic Agents. Luo, Z; Shivakumar, P; Mourya, R; Gutta, S; Bezerra, JA. Gastroenterology. 2019; 157:1138-1152.e14.

Visualizing Structures in Confocal Microscopy Datasets Through Clusterization: A Case Study on Bile Ducts. Beltran, LA C; Cruz, CU; dos Santos, JL; Shivakumar, P; Bezerra, J; Freitas, CM D S; IEEE, . (2019) 00:405-410.

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