A photo of Pranavkumar Shivakumar.

Assistant Professor, UC Department of Pediatrics

513-636-3676

513-636-5581

Biography & Affiliation

Research Interests

Dissecting molecular mechanisms and pathways involved in the pathogenesis of biliary atresia

Academic Affiliation

Assistant Professor, UC Department of Pediatrics

Research Divisions

Gastroenterology Hepatology and Nutrition



Blog Posts

Education

PhD: University of Bombay, Bombay, India, 2002.

MPharm: University of Bombay, Bombay, India, 1997.

Publications

Selected Publication

Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells. Asai, A; Aihara, E; Watson, C; Mourya, R; Mizuochi, T; Shivakumar, P; Phelan, K; Mayhew, C; Helmrath, M; Takebe, T; et al. Development (Cambridge). 2017; 144:1056-1064.

Preferential TNFα signaling via TNFR2 regulates epithelial injury and duct obstruction in experimental biliary atresia. Shivakumar, P; Mizuochi, T; Mourya, R; Gutta, S; Yang, L; Luo, Z; Bezerra, JA. JCI insight. 2017; 2.

"Complimenting the Complement ": Mechanistic Insights and Opportunities for Therapeutics in Hepatocellular Carcinoma. Malik, A; Thanekar, U; Amarachintha, S; Mourya, R; Nalluri, S; Bondoc, A; Shivakumar, P. Frontiers in Oncology. 2021; 10.

Recent developments in etiology and disease modeling of biliary atresia: a narrative review. Malik, A; Thanekar, U; Mourya, R; Shivakumar, P. Digestive medicine research.. 2020; 3.

Regulation of bile duct epithelial injury by hepatic CD71+ erythroid cells. Yang, L; Shivakumar, P; Kinder, J; Way, SS; Donnelly, B; Mourya, R; Luo, Z; Bezerra, JA. JCI insight. 2020; 5.

Gene Expression Signatures Associated With Survival Times of Pediatric Patients With Biliary Atresia Identify Potential Therapeutic Agents. Luo, Z; Shivakumar, P; Mourya, R; Gutta, S; Bezerra, JA. Gastroenterology. 2019; 157:1138-1152.e14.

Visualizing Structures in Confocal Microscopy Datasets Through Clusterization: A Case Study on Bile Ducts. Beltran, LA C; Cruz, CU; dos Santos, JL; Shivakumar, P; Bezerra, J; Freitas, CM D S; IEEE, . (2019) 00:405-410.

Single cell RNA sequencing reveals regional heterogeneity of hepatobiliary innate lymphoid cells in a tissue-enriched fashion. Peters, AL; Luo, Z; Li, J; Mourya, R; Wang, Y; Dexheimer, P; Shivakumar, P; Aronow, B; Bezerra, JA. PLoS ONE. 2019; 14.

Regulation of epithelial injury and bile duct obstruction by NLRP3, IL-1R1 in experimental biliary atresia. Yang, L; Mizuochi, T; Shivakumar, P; Mourya, R; Luo, Z; Gutta, S; Bezerra, JA. Journal of Hepatology. 2018; 69:1136-1144.

A Novel Pkhd1 Mutation Interacts with the Nonobese Diabetic Genetic Background To Cause Autoimmune Cholangitis. Huang, W; Rainbow, DB; Wu, Y; Adams, D; Shivakumar, P; Kottyan, L; Karns, R; Aronow, B; Bezerra, J; Gershwin, ME; et al. Journal of Immunology. 2018; 200:147-162.