A photo of Shannon M. Standridge.

Director, Rett Syndrome Clinic

Epilepsy Specialist, Division of Neurology

Assistant Professor, UC Department of Pediatrics



Board Certified

My Biography & Research


As a pediatric neurologist, I focus on listening to my patients and their caregivers. I practice with a “whole person” approach rather than a single organ system approach.

When I see patients, I thoroughly listen to their concerns. I answer their questions with care and transparency. During each visit, from the moment we start until we finish, the family and the patient have all my attention.

To ensure that I’m providing the most advanced care, I stay updated on the literature. I strive to bring the most current information into the way I practice.

I specialize in caring for children with refractory epilepsy, Rett syndrome and related conditions. I’m honored that the Rett Syndrome and Related Spectrum Disorders Clinic at Cincinnati Children’s is recognized as a Research Center of Excellence by RettSyndrome.org.

I was always drawn to medicine and pediatrics. My interest in pediatric neurology developed through my work with outstanding clinicians, including Dr. Warren Lo and Dr. Suja Ann Joseph. They convinced me that neurology was the right specialty for me.

As a specialist in Rett syndrome and related disorders, I work on several different studies evaluating the safety and efficacy of different treatment drugs. I also serve on a Rett consortium that continuously works to provide science-based guidelines and current care and management approaches. We also publish manuscripts about what we learn from the scientific data in our natural history study findings.

Here are some fun facts about me: I competed in the Hawaii World Ironman Championship. I carried the Olympic Torch for the U.S. Winter Olympics in 2002. My favorite pastimes include hiking and biking outdoors with family and renovating houses.

Clinical Interests

General neurology

Academic Affiliation

Assistant Professor, UC Department of Pediatrics

Clinical Divisions

Neurology, Epilepsy, Rett Syndrome

Research Divisions


My Locations

My Education

Fellowship: Neurophysiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2008; Neurology, Nationwide Children's Hospital, Columbus, OH, 2007.

Residency: Pediatrics, Nationwide Children's Hospital, Columbus, OH, 2004.

MPH: The Ohio State University College of Public Health, Columbus, OH, 2008.

DO: Kansas City University of Medicine and Biosciences, Kansas City, MO, 2002.

BS: Biology, Lyon College, Batesville, AS, 1997.

My Publications

Consensus guidelines on managing Rett syndrome across the lifespan. Fu, C; Armstrong, D; Marsh, E; Lieberman, D; Motil, K; Witt, R; Standridge, S; Nues, P; Lane, J; Dinkel, T; et al. BMJ Paediatrics Open. 2020; 4:e000717-e000717.

Multisystem comorbidities in classic Rett syndrome: a scoping review. Fu, C; Armstrong, D; Marsh, E; Lieberman, D; Motil, K; Witt, R; Standridge, S; Lane, J; Dinkel, T; Jones, M; et al. BMJ Paediatrics Open. 2020; 4:e000731-e000731.

Characterizing the phenotypic effect of Xq28 duplication size in MECP2 duplication syndrome. Peters, SU; Fu, C; Suter, B; Marsh, E; Benke, TA; Skinner, SA; Lieberman, DN; Standridge, S; Jones, M; Beisang, A; et al. Clinical Genetics: an international journal of genetics and molecular medicine. 2019; 95:575-581.

Double-blind, randomized, placebo-controlled study of trofinetide in pediatric Rett syndrome. Glaze, DG; Neul, JL; Kaufmann, WE; Berry-Kravis, E; Condon, S; Stoms, G; Oosterholt, S; Della Pasqua, O; Glass, L; Jones, NE; et al. Neurology. 2019; 92:E1912-E1925.

The array of clinical phenotypes of males with mutations in Methyl-CpG binding protein 2. Neul, JL; Benke, TA; Marsh, ED; Skinner, SA; Merritt, J; Lieberman, DN; Standridge, S; Feyma, T; Heydemann, P; Peters, S; et al. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 2019; 180:55-67.

A Case of An Unusual Bell's Palsy Mimic. Lutley, AL; Standridge, SM. Seminars in Pediatric Neurology. 2018; 26:77-79.

An Atypical Rett Syndrome Phenotype Due to a Novel Missense Mutation in CACNA1A. Epperson, MV; Haws, ME; Standridge, SM; Gilbert, DL. Journal of Child Neurology. 2018; 33:286-289.

Drug-resistant epilepsy in children with partial onset epilepsy treated with carbamazepine. Aungaroon, G; Holland, KD; Horn, PS; Standridge, SM; Imming, CM. International Journal of Neuroscience. 2017; 127:849-853.

The Clinical Predictors That Facilitate a Clinician's Decision to Order Genetic Testing for Rett Syndrome. Knight, VM; Horn, PS; Gilbert, DL; Standridge, SM. Pediatric Neurology. 2016; 63:66-70.

Methodological Issues in Predicting Pediatric Epilepsy Surgery Candidates Through Natural Language Processing and Machine Learning. Cohen, KB; Glass, B; Greiner, HM; Holland-Bouley, K; Standridge, S; Arya, R; Faist, R; Morita, D; Mangano, F; Connolly, B; et al. Biomedical Informatics Insights. 2016; 8:BII.S38308-BII.S38308.